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Article: Nitric oxide: orchestrator of endothelium-dependent responses

TitleNitric oxide: orchestrator of endothelium-dependent responses
Authors
KeywordsAtherosclerosis
Cyclo-oxygenase
Cytochrome P450 mono-oxygenase
Diabetes
Lipoxygenase
Potassium channels
Soluble epoxide hydrolase
Tetrahydrobiopterin
Endothelin
Hypertension
Nitric oxide synthase
Oxidative stress
Issue Date2012
PublisherTaylor & Francis A B. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07853890.html
Citation
Annals of Medicine, 2012, v. 44 n. 7, p. 694-716 How to Cite?
AbstractThe present review first summarizes the complex chain of events, in endothelial and vascular smooth muscle cells, that leads to endothelium- dependent relaxations (vasodilatations) due to the generation of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) and how therapeutic interventions may improve the bioavailability of NO and thus prevent/cure endothelial dysfunction. Then, the role of other endothelium-derived mediators (endothelium-derived hyperpolarizing (EDHF) and contracting (EDCF) factors, endothelin-1) and signals (myoendothelial coupling) is summarized also, with special emphasis on their interaction(s) with the NO pathway, which make the latter not only a major mediator but also a key regulator of endothelium-dependent responses. © 2012 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/146894
ISSN
2015 Impact Factor: 3.763
2015 SCImago Journal Rankings: 1.658
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFélétou, Men_US
dc.contributor.authorKöhler, Ren_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-05-23T05:48:51Z-
dc.date.available2012-05-23T05:48:51Z-
dc.date.issued2012en_US
dc.identifier.citationAnnals of Medicine, 2012, v. 44 n. 7, p. 694-716en_US
dc.identifier.issn0785-3890-
dc.identifier.urihttp://hdl.handle.net/10722/146894-
dc.description.abstractThe present review first summarizes the complex chain of events, in endothelial and vascular smooth muscle cells, that leads to endothelium- dependent relaxations (vasodilatations) due to the generation of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) and how therapeutic interventions may improve the bioavailability of NO and thus prevent/cure endothelial dysfunction. Then, the role of other endothelium-derived mediators (endothelium-derived hyperpolarizing (EDHF) and contracting (EDCF) factors, endothelin-1) and signals (myoendothelial coupling) is summarized also, with special emphasis on their interaction(s) with the NO pathway, which make the latter not only a major mediator but also a key regulator of endothelium-dependent responses. © 2012 Informa UK, Ltd.-
dc.languageengen_US
dc.publisherTaylor & Francis A B. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07853890.html-
dc.relation.ispartofAnnals of Medicineen_US
dc.subjectAtherosclerosis-
dc.subjectCyclo-oxygenase-
dc.subjectCytochrome P450 mono-oxygenase-
dc.subjectDiabetes-
dc.subjectLipoxygenase-
dc.subjectPotassium channels-
dc.subjectSoluble epoxide hydrolase-
dc.subjectTetrahydrobiopterin-
dc.subjectEndothelin-
dc.subjectHypertension-
dc.subjectNitric oxide synthase-
dc.subjectOxidative stress-
dc.titleNitric oxide: orchestrator of endothelium-dependent responsesen_US
dc.typeArticleen_US
dc.identifier.emailFélétou, M: michel.feletou@fr.netgrs.comen_US
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hk-
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/07853890.2011.585658-
dc.identifier.pmid21895549-
dc.identifier.scopuseid_2-s2.0-84867026935-
dc.identifier.hkuros199782en_US
dc.identifier.volume44-
dc.identifier.issue7-
dc.identifier.spage694en_US
dc.identifier.epage716en_US
dc.identifier.isiWOS:000310371400007-
dc.publisher.placeSweden-

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