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Article: Visfatin and cardio-cerebro-vascular disease

TitleVisfatin and cardio-cerebro-vascular disease
Authors
Keywordsadipokine
atherosclerosis
coronary artery disease
hypertension
stroke
vascular biology
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 2012, v. 59 n. 1, p. 1-9 How to Cite?
AbstractNicotinamide phosphoribosyltransferase is the rate-limiting enzyme that catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide from nicotinamide. This protein was originally cloned as a putative pre-B cell colony-enhancing factor and also found to be a visceral fat-derived adipokine (visfatin). As a multifunctional protein, visfatin plays an important role in immunity, metabolism, aging, inflammation, and responses to stress. Visfatin also participates in several pathophysiological processes contributing to cardio-cerebro-vascular diseases, including hypertension, atherosclerosis, ischemic heart disease, and ischemic stroke. However, whether visfatin is a friend or a foe in these diseases remains uncertain. This brief review focuses on the current understanding of the complex role of visfatin in the cardio-cerebro-vascular system under normal and pathophysiological conditions. © 2012 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/146891
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID
Funding AgencyGrant Number
National Basic Research Program of China2009CB521902
National Natural Science Foundation of China for Distinguished Young Scholars30525045
National Science and Technology Major Project2009ZX09303-002
Program of Shanghai Subject Chief Scientist10XD1405300
"Shizhen Scholar Project of Pharmacy School, SMMU
Funding Information:

Supported by grants from the National Basic Research Program of China (2009CB521902 to C.-Y.M.), the National Natural Science Foundation of China for Distinguished Young Scholars (30525045 to C.-Y.M.), the National Science and Technology Major Project (2009ZX09303-002 to C.-Y.M.), the Program of Shanghai Subject Chief Scientist (10XD1405300 to C.-Y.M.), and the "Shizhen Scholar Project of Pharmacy School, SMMU" (to P.W.).

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Pen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorMiao, CYen_HK
dc.date.accessioned2012-05-23T05:48:50Z-
dc.date.available2012-05-23T05:48:50Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 2012, v. 59 n. 1, p. 1-9en_HK
dc.identifier.issn0160-2446en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146891-
dc.description.abstractNicotinamide phosphoribosyltransferase is the rate-limiting enzyme that catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide from nicotinamide. This protein was originally cloned as a putative pre-B cell colony-enhancing factor and also found to be a visceral fat-derived adipokine (visfatin). As a multifunctional protein, visfatin plays an important role in immunity, metabolism, aging, inflammation, and responses to stress. Visfatin also participates in several pathophysiological processes contributing to cardio-cerebro-vascular diseases, including hypertension, atherosclerosis, ischemic heart disease, and ischemic stroke. However, whether visfatin is a friend or a foe in these diseases remains uncertain. This brief review focuses on the current understanding of the complex role of visfatin in the cardio-cerebro-vascular system under normal and pathophysiological conditions. © 2012 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_HK
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_HK
dc.subjectadipokineen_HK
dc.subjectatherosclerosisen_HK
dc.subjectcoronary artery diseaseen_HK
dc.subjecthypertensionen_HK
dc.subjectstrokeen_HK
dc.subjectvascular biologyen_HK
dc.subject.meshAdipose Tissue - metabolism-
dc.subject.meshCardiovascular Diseases - blood - etiology - metabolism-
dc.subject.meshCerebrovascular Disorders - blood - etiology - metabolism-
dc.subject.meshEndothelium, Vascular - metabolism-
dc.subject.meshNicotinamide Phosphoribosyltransferase - blood - chemistry - genetics - physiology-
dc.titleVisfatin and cardio-cerebro-vascular diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/FJC.0b013e31820eb8f6en_HK
dc.identifier.pmid21266913en_HK
dc.identifier.scopuseid_2-s2.0-84855351865en_HK
dc.identifier.hkuros199413en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855351865&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage9en_HK
dc.identifier.isiWOS:000298669500001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, P=36844930500en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridMiao, CY=7103074878en_HK

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