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- Publisher Website: 10.1097/FJC.0b013e31820eb8f6
- Scopus: eid_2-s2.0-84855351865
- PMID: 21266913
- WOS: WOS:000298669500001
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Article: Visfatin and cardio-cerebro-vascular disease
Title | Visfatin and cardio-cerebro-vascular disease | ||||||||||||
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Authors | |||||||||||||
Keywords | adipokine atherosclerosis coronary artery disease hypertension stroke vascular biology | ||||||||||||
Issue Date | 2012 | ||||||||||||
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | ||||||||||||
Citation | Journal Of Cardiovascular Pharmacology, 2012, v. 59 n. 1, p. 1-9 How to Cite? | ||||||||||||
Abstract | Nicotinamide phosphoribosyltransferase is the rate-limiting enzyme that catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide from nicotinamide. This protein was originally cloned as a putative pre-B cell colony-enhancing factor and also found to be a visceral fat-derived adipokine (visfatin). As a multifunctional protein, visfatin plays an important role in immunity, metabolism, aging, inflammation, and responses to stress. Visfatin also participates in several pathophysiological processes contributing to cardio-cerebro-vascular diseases, including hypertension, atherosclerosis, ischemic heart disease, and ischemic stroke. However, whether visfatin is a friend or a foe in these diseases remains uncertain. This brief review focuses on the current understanding of the complex role of visfatin in the cardio-cerebro-vascular system under normal and pathophysiological conditions. © 2012 Lippincott Williams & Wilkins, Inc. | ||||||||||||
Persistent Identifier | http://hdl.handle.net/10722/146891 | ||||||||||||
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 | ||||||||||||
ISI Accession Number ID |
Funding Information: Supported by grants from the National Basic Research Program of China (2009CB521902 to C.-Y.M.), the National Natural Science Foundation of China for Distinguished Young Scholars (30525045 to C.-Y.M.), the National Science and Technology Major Project (2009ZX09303-002 to C.-Y.M.), the Program of Shanghai Subject Chief Scientist (10XD1405300 to C.-Y.M.), and the "Shizhen Scholar Project of Pharmacy School, SMMU" (to P.W.). | ||||||||||||
References |
DC Field | Value | Language |
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dc.contributor.author | Wang, P | en_HK |
dc.contributor.author | Vanhoutte, PM | en_HK |
dc.contributor.author | Miao, CY | en_HK |
dc.date.accessioned | 2012-05-23T05:48:50Z | - |
dc.date.available | 2012-05-23T05:48:50Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 2012, v. 59 n. 1, p. 1-9 | en_HK |
dc.identifier.issn | 0160-2446 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/146891 | - |
dc.description.abstract | Nicotinamide phosphoribosyltransferase is the rate-limiting enzyme that catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide from nicotinamide. This protein was originally cloned as a putative pre-B cell colony-enhancing factor and also found to be a visceral fat-derived adipokine (visfatin). As a multifunctional protein, visfatin plays an important role in immunity, metabolism, aging, inflammation, and responses to stress. Visfatin also participates in several pathophysiological processes contributing to cardio-cerebro-vascular diseases, including hypertension, atherosclerosis, ischemic heart disease, and ischemic stroke. However, whether visfatin is a friend or a foe in these diseases remains uncertain. This brief review focuses on the current understanding of the complex role of visfatin in the cardio-cerebro-vascular system under normal and pathophysiological conditions. © 2012 Lippincott Williams & Wilkins, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_HK |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_HK |
dc.subject | adipokine | en_HK |
dc.subject | atherosclerosis | en_HK |
dc.subject | coronary artery disease | en_HK |
dc.subject | hypertension | en_HK |
dc.subject | stroke | en_HK |
dc.subject | vascular biology | en_HK |
dc.subject.mesh | Adipose Tissue - metabolism | - |
dc.subject.mesh | Cardiovascular Diseases - blood - etiology - metabolism | - |
dc.subject.mesh | Cerebrovascular Disorders - blood - etiology - metabolism | - |
dc.subject.mesh | Endothelium, Vascular - metabolism | - |
dc.subject.mesh | Nicotinamide Phosphoribosyltransferase - blood - chemistry - genetics - physiology | - |
dc.title | Visfatin and cardio-cerebro-vascular disease | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | en_HK |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/FJC.0b013e31820eb8f6 | en_HK |
dc.identifier.pmid | 21266913 | en_HK |
dc.identifier.scopus | eid_2-s2.0-84855351865 | en_HK |
dc.identifier.hkuros | 199413 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84855351865&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 59 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 1 | en_HK |
dc.identifier.epage | 9 | en_HK |
dc.identifier.isi | WOS:000298669500001 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wang, P=36844930500 | en_HK |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_HK |
dc.identifier.scopusauthorid | Miao, CY=7103074878 | en_HK |
dc.identifier.issnl | 0160-2446 | - |