Article: Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function
| Title | Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Chan, YH1 Lau, KK1 Yiu, KH Siu, CW Chan, HT Li, SW Tam, S Lam, TH Lau, CP Tse, HF1 | ||||||
| Keywords | Diet Isoflavone Recurrent stroke Secondary prevention Vascular function | ||||||
| Issue Date | 2012 | ||||||
| Publisher | Editions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603 | ||||||
| Citation | Journal Of Nutrition, Health And Aging, 2012, v. 16 n. 4, p. 383-388 [How to Cite?] DOI: http://dx.doi.org/10.1007/s12603-012-0048-6 | ||||||
| Abstract | Background: Whether isoflavone has any effect on recurrent cardiovascular events is unknown. Objective: To investigate the relations between isoflavone intake and the risk of stroke recurrence. Subjects and Methods: We recruited 127 consecutive patients with prior history of atherothrombotic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (maCe) were documented. Brachial flow-mediated dilatation (FmD) was measured using high-resolution ultrasound. isoflavone intake was estimated using a validated food frequency questionnaire. Results: median isoflavone intake was 6.9 (range: 2.1-14.5) mg/day. isoflavone intake was independently associated with increased FmD (Pearson R=0.23, p=0.012). at 30 months, there were 10 stroke recurrence and 12 maCe. Kaplan-meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4-27.6] mth versus 5.0 [range: 4.1-5.9] mth, p=0.021) and maCe-free survival time (19.0 [range: 10.4-27.6] mth versus 4.0 [range: 2.4-5.6] mth, p=0.013). using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%Ci: 0.03-0.95], risk reduction 82%, p=0.043) and maCe (hazards ratio 0.16 [95%Ci: 0.03-0.84], risk reduction 84%, p=0.030). Conclusions: Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and maCe independent of baseline vascular function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial. | ||||||
| ISSN | 1279-7707 2011 Impact Factor: 2.686 2011 SCImago Journal Rankings: 0.133 | ||||||
| DOI | http://dx.doi.org/10.1007/s12603-012-0048-6 | ||||||
| ISI Accession Number ID | WOS:000304134500021
Funding Information: This study was supported by CRCG Small Project Funding of University of Hong Kong (Project no. 200807176179) and the Sun Chieh Yeh Heart Foundation. | ||||||
| References | References in Scopus | ||||||
| Grants | Effect of Isoflavone Supplement on Endothelial Function in Patients with Ischaemic Stroke |
| dc.contributor.author | Chan, YH | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lau, KK | ||||||
| dc.contributor.author | Yiu, KH | ||||||
| dc.contributor.author | Siu, CW | ||||||
| dc.contributor.author | Chan, HT | ||||||
| dc.contributor.author | Li, SW | ||||||
| dc.contributor.author | Tam, S | ||||||
| dc.contributor.author | Lam, TH | ||||||
| dc.contributor.author | Lau, CP | ||||||
| dc.contributor.author | Tse, HF | ||||||
| dc.date.accessioned | 2012-05-23T05:48:28Z | ||||||
| dc.date.available | 2012-05-23T05:48:28Z | ||||||
| dc.date.issued | 2012 | ||||||
| dc.description.abstract | Background: Whether isoflavone has any effect on recurrent cardiovascular events is unknown. Objective: To investigate the relations between isoflavone intake and the risk of stroke recurrence. Subjects and Methods: We recruited 127 consecutive patients with prior history of atherothrombotic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (maCe) were documented. Brachial flow-mediated dilatation (FmD) was measured using high-resolution ultrasound. isoflavone intake was estimated using a validated food frequency questionnaire. Results: median isoflavone intake was 6.9 (range: 2.1-14.5) mg/day. isoflavone intake was independently associated with increased FmD (Pearson R=0.23, p=0.012). at 30 months, there were 10 stroke recurrence and 12 maCe. Kaplan-meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4-27.6] mth versus 5.0 [range: 4.1-5.9] mth, p=0.021) and maCe-free survival time (19.0 [range: 10.4-27.6] mth versus 4.0 [range: 2.4-5.6] mth, p=0.013). using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%Ci: 0.03-0.95], risk reduction 82%, p=0.043) and maCe (hazards ratio 0.16 [95%Ci: 0.03-0.84], risk reduction 84%, p=0.030). Conclusions: Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and maCe independent of baseline vascular function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial. | ||||||
| dc.description.grant | Effect of Isoflavone Supplement on Endothelial Function in Patients with Ischaemic Stroke | ||||||
| dc.description.grantcode | 99223 | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Journal Of Nutrition, Health And Aging, 2012, v. 16 n. 4, p. 383-388 [How to Cite?] DOI: http://dx.doi.org/10.1007/s12603-012-0048-6 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1007/s12603-012-0048-6 | ||||||
| dc.identifier.epage | 388 | ||||||
| dc.identifier.hkuros | 199408 | ||||||
| dc.identifier.isi | WOS:000304134500021
Funding Information: This study was supported by CRCG Small Project Funding of University of Hong Kong (Project no. 200807176179) and the Sun Chieh Yeh Heart Foundation. | ||||||
| dc.identifier.issn | 1279-7707 2011 Impact Factor: 2.686 2011 SCImago Journal Rankings: 0.133 | ||||||
| dc.identifier.issue | 4 | ||||||
| dc.identifier.pmid | 22499463 | ||||||
| dc.identifier.scopus | eid_2-s2.0-84863445209 | ||||||
| dc.identifier.spage | 383 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/146882 | ||||||
| dc.identifier.volume | 16 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Editions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603 | ||||||
| dc.publisher.place | France | ||||||
| dc.relation.ispartof | Journal of Nutrition, Health and Aging | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject | Diet | ||||||
| dc.subject | Isoflavone | ||||||
| dc.subject | Recurrent stroke | ||||||
| dc.subject | Secondary prevention | ||||||
| dc.subject | Vascular function | ||||||
| dc.title | Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Queen Mary Hospital Hong Kong
- Tung Wah Hospital