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Article: Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function
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TitleProspective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function
 
AuthorsChan, YH1
Lau, KK1
Yiu, KH1
Siu, CW1
Chan, HT1
Li, SW3
Tam, S2
Lam, TH1
Lau, CP1
Tse, HF1
 
KeywordsDiet
Isoflavone
Recurrent stroke
Secondary prevention
Vascular function
 
Issue Date2012
 
PublisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
 
CitationJournal Of Nutrition, Health And Aging, 2012, v. 16 n. 4, p. 383-388 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s12603-012-0048-6
 
AbstractBackground: Whether isoflavone has any effect on recurrent cardiovascular events is unknown. Objective: To investigate the relations between isoflavone intake and the risk of stroke recurrence. Subjects and Methods: We recruited 127 consecutive patients with prior history of atherothrombotic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (maCe) were documented. Brachial flow-mediated dilatation (FmD) was measured using high-resolution ultrasound. isoflavone intake was estimated using a validated food frequency questionnaire. Results: median isoflavone intake was 6.9 (range: 2.1-14.5) mg/day. isoflavone intake was independently associated with increased FmD (Pearson R=0.23, p=0.012). at 30 months, there were 10 stroke recurrence and 12 maCe. Kaplan-meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4-27.6] mth versus 5.0 [range: 4.1-5.9] mth, p=0.021) and maCe-free survival time (19.0 [range: 10.4-27.6] mth versus 4.0 [range: 2.4-5.6] mth, p=0.013). using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%Ci: 0.03-0.95], risk reduction 82%, p=0.043) and maCe (hazards ratio 0.16 [95%Ci: 0.03-0.84], risk reduction 84%, p=0.030). Conclusions: Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and maCe independent of baseline vascular function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial.
 
ISSN1279-7707
2013 Impact Factor: 2.659
2013 SCImago Journal Rankings: 0.886
 
DOIhttp://dx.doi.org/10.1007/s12603-012-0048-6
 
ISI Accession Number IDWOS:000304134500021
Funding AgencyGrant Number
CRCG of University of Hong Kong200807176179
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by CRCG Small Project Funding of University of Hong Kong (Project no. 200807176179) and the Sun Chieh Yeh Heart Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, YH
 
dc.contributor.authorLau, KK
 
dc.contributor.authorYiu, KH
 
dc.contributor.authorSiu, CW
 
dc.contributor.authorChan, HT
 
dc.contributor.authorLi, SW
 
dc.contributor.authorTam, S
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLau, CP
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2012-05-23T05:48:28Z
 
dc.date.available2012-05-23T05:48:28Z
 
dc.date.issued2012
 
dc.description.abstractBackground: Whether isoflavone has any effect on recurrent cardiovascular events is unknown. Objective: To investigate the relations between isoflavone intake and the risk of stroke recurrence. Subjects and Methods: We recruited 127 consecutive patients with prior history of atherothrombotic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (maCe) were documented. Brachial flow-mediated dilatation (FmD) was measured using high-resolution ultrasound. isoflavone intake was estimated using a validated food frequency questionnaire. Results: median isoflavone intake was 6.9 (range: 2.1-14.5) mg/day. isoflavone intake was independently associated with increased FmD (Pearson R=0.23, p=0.012). at 30 months, there were 10 stroke recurrence and 12 maCe. Kaplan-meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4-27.6] mth versus 5.0 [range: 4.1-5.9] mth, p=0.021) and maCe-free survival time (19.0 [range: 10.4-27.6] mth versus 4.0 [range: 2.4-5.6] mth, p=0.013). using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%Ci: 0.03-0.95], risk reduction 82%, p=0.043) and maCe (hazards ratio 0.16 [95%Ci: 0.03-0.84], risk reduction 84%, p=0.030). Conclusions: Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and maCe independent of baseline vascular function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Nutrition, Health And Aging, 2012, v. 16 n. 4, p. 383-388 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s12603-012-0048-6
 
dc.identifier.doihttp://dx.doi.org/10.1007/s12603-012-0048-6
 
dc.identifier.epage388
 
dc.identifier.hkuros199408
 
dc.identifier.hkuros194719
 
dc.identifier.isiWOS:000304134500021
Funding AgencyGrant Number
CRCG of University of Hong Kong200807176179
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by CRCG Small Project Funding of University of Hong Kong (Project no. 200807176179) and the Sun Chieh Yeh Heart Foundation.

 
dc.identifier.issn1279-7707
2013 Impact Factor: 2.659
2013 SCImago Journal Rankings: 0.886
 
dc.identifier.issue4
 
dc.identifier.pmid22499463
 
dc.identifier.scopuseid_2-s2.0-84863445209
 
dc.identifier.spage383
 
dc.identifier.urihttp://hdl.handle.net/10722/146882
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
 
dc.publisher.placeFrance
 
dc.relation.ispartofJournal of Nutrition, Health and Aging
 
dc.relation.referencesReferences in Scopus
 
dc.subjectDiet
 
dc.subjectIsoflavone
 
dc.subjectRecurrent stroke
 
dc.subjectSecondary prevention
 
dc.subjectVascular function
 
dc.titleProspective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function
 
dc.typeArticle
 
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<contributor.author>Yiu, KH</contributor.author>
<contributor.author>Siu, CW</contributor.author>
<contributor.author>Chan, HT</contributor.author>
<contributor.author>Li, SW</contributor.author>
<contributor.author>Tam, S</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
  3. Tung Wah Hospital