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Article: Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function

TitleProspective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function
Authors
KeywordsDiet
Isoflavone
Recurrent stroke
Secondary prevention
Vascular function
Issue Date2012
PublisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
Citation
Journal Of Nutrition, Health And Aging, 2012, v. 16 n. 4, p. 383-388 How to Cite?
Abstract
Background: Whether isoflavone has any effect on recurrent cardiovascular events is unknown. Objective: To investigate the relations between isoflavone intake and the risk of stroke recurrence. Subjects and Methods: We recruited 127 consecutive patients with prior history of atherothrombotic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (maCe) were documented. Brachial flow-mediated dilatation (FmD) was measured using high-resolution ultrasound. isoflavone intake was estimated using a validated food frequency questionnaire. Results: median isoflavone intake was 6.9 (range: 2.1-14.5) mg/day. isoflavone intake was independently associated with increased FmD (Pearson R=0.23, p=0.012). at 30 months, there were 10 stroke recurrence and 12 maCe. Kaplan-meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4-27.6] mth versus 5.0 [range: 4.1-5.9] mth, p=0.021) and maCe-free survival time (19.0 [range: 10.4-27.6] mth versus 4.0 [range: 2.4-5.6] mth, p=0.013). using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%Ci: 0.03-0.95], risk reduction 82%, p=0.043) and maCe (hazards ratio 0.16 [95%Ci: 0.03-0.84], risk reduction 84%, p=0.030). Conclusions: Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and maCe independent of baseline vascular function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial.
Persistent Identifierhttp://hdl.handle.net/10722/146882
ISSN
2013 Impact Factor: 2.659
2013 SCImago Journal Rankings: 0.886
ISI Accession Number ID
Funding AgencyGrant Number
CRCG of University of Hong Kong200807176179
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by CRCG Small Project Funding of University of Hong Kong (Project no. 200807176179) and the Sun Chieh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, YHen_HK
dc.contributor.authorLau, KKen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2012-05-23T05:48:28Z-
dc.date.available2012-05-23T05:48:28Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Nutrition, Health And Aging, 2012, v. 16 n. 4, p. 383-388en_HK
dc.identifier.issn1279-7707en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146882-
dc.description.abstractBackground: Whether isoflavone has any effect on recurrent cardiovascular events is unknown. Objective: To investigate the relations between isoflavone intake and the risk of stroke recurrence. Subjects and Methods: We recruited 127 consecutive patients with prior history of atherothrombotic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (maCe) were documented. Brachial flow-mediated dilatation (FmD) was measured using high-resolution ultrasound. isoflavone intake was estimated using a validated food frequency questionnaire. Results: median isoflavone intake was 6.9 (range: 2.1-14.5) mg/day. isoflavone intake was independently associated with increased FmD (Pearson R=0.23, p=0.012). at 30 months, there were 10 stroke recurrence and 12 maCe. Kaplan-meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4-27.6] mth versus 5.0 [range: 4.1-5.9] mth, p=0.021) and maCe-free survival time (19.0 [range: 10.4-27.6] mth versus 4.0 [range: 2.4-5.6] mth, p=0.013). using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%Ci: 0.03-0.95], risk reduction 82%, p=0.043) and maCe (hazards ratio 0.16 [95%Ci: 0.03-0.84], risk reduction 84%, p=0.030). Conclusions: Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and maCe independent of baseline vascular function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial.en_HK
dc.languageengen_US
dc.publisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603en_HK
dc.relation.ispartofJournal of Nutrition, Health and Agingen_HK
dc.subjectDieten_HK
dc.subjectIsoflavoneen_HK
dc.subjectRecurrent strokeen_HK
dc.subjectSecondary preventionen_HK
dc.subjectVascular functionen_HK
dc.titleProspective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular functionen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailLau, KK:gkklau@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authorityLau, KK=rp01499en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12603-012-0048-6en_HK
dc.identifier.pmid22499463-
dc.identifier.scopuseid_2-s2.0-84863445209en_HK
dc.identifier.hkuros199408en_US
dc.identifier.hkuros194719-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863445209&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage383en_HK
dc.identifier.epage388en_HK
dc.identifier.isiWOS:000304134500021-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridLau, KK=22635159600en_HK
dc.identifier.scopusauthoridYiu, KH=55165418600en_HK
dc.identifier.scopusauthoridSiu, CW=55140738400en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridTam, S=55293309000en_HK
dc.identifier.scopusauthoridLam, TH=55114358700en_HK
dc.identifier.scopusauthoridLau, CP=55264335600en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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