File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Enhancement of anticancer efficacy using modified lipophilic nanoparticle drug encapsulation.

TitleEnhancement of anticancer efficacy using modified lipophilic nanoparticle drug encapsulation.
Authors
Issue Date2012
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5
Citation
International Journal Of Nanomedicine, 2012, v. 7, p. 731-737 How to Cite?
AbstractDevelopment of anticancer drugs is challenging. Indeed, much research effort has been spent in the development of new drugs to improve clinical outcomes with minimal toxicity. We have previously reported that a formulation of lipid gold porphyrin nanoparticles reduced systemic drug toxicity when compared with free gold porphyrin. In this study, we investigated the delivery and treatment efficiency of PEG surface-modified lipid nanoparticles as a carrier platform. We encapsulated antitumor drugs into PEG-modified lipid nanoparticles and these were characterized by size, zeta potential, and encapsulation efficiency. The delivery efficiency into tumor tissue was evaluated using a biodistribution study. To evaluate antitumor efficacy, gold porphyrin or camptothecin (a DNA topoisomerase I inhibitor) were encapsulated and compared using an in vivo neuroblastoma (N2A) model. We showed that drug encapsulation into PEG-modified lipid nanoparticles enhanced the preferential uptake in tumor tissue. Furthermore, higher tumor killing efficiency was observed in response to treatment with PEG-modified lipid nanoparticles encapsulating gold porphyrin or camptothecin when compared with free gold porphyrin or free camptothecin. The in vivo antitumor effect was further confirmed by study of tumor inhibition and positive apoptosis activity. Surface modification of lipophilic nanoparticles with PEG increased the efficiency of drug delivery into tumor tissue and subsequently more effective antitumor activity. This specific design of a chemotherapeutic agent using nanotechnology is important in the development of a safe and effective drug in cancer therapy.
Persistent Identifierhttp://hdl.handle.net/10722/146855
ISSN
2015 Impact Factor: 4.32
2015 SCImago Journal Rankings: 1.351
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Pen_HK
dc.contributor.authorZhang, Ren_HK
dc.contributor.authorLi, Ven_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorWong, KKYen_HK
dc.date.accessioned2012-05-23T05:42:46Z-
dc.date.available2012-05-23T05:42:46Z-
dc.date.issued2012en_HK
dc.identifier.citationInternational Journal Of Nanomedicine, 2012, v. 7, p. 731-737en_HK
dc.identifier.issn1178-2013en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146855-
dc.description.abstractDevelopment of anticancer drugs is challenging. Indeed, much research effort has been spent in the development of new drugs to improve clinical outcomes with minimal toxicity. We have previously reported that a formulation of lipid gold porphyrin nanoparticles reduced systemic drug toxicity when compared with free gold porphyrin. In this study, we investigated the delivery and treatment efficiency of PEG surface-modified lipid nanoparticles as a carrier platform. We encapsulated antitumor drugs into PEG-modified lipid nanoparticles and these were characterized by size, zeta potential, and encapsulation efficiency. The delivery efficiency into tumor tissue was evaluated using a biodistribution study. To evaluate antitumor efficacy, gold porphyrin or camptothecin (a DNA topoisomerase I inhibitor) were encapsulated and compared using an in vivo neuroblastoma (N2A) model. We showed that drug encapsulation into PEG-modified lipid nanoparticles enhanced the preferential uptake in tumor tissue. Furthermore, higher tumor killing efficiency was observed in response to treatment with PEG-modified lipid nanoparticles encapsulating gold porphyrin or camptothecin when compared with free gold porphyrin or free camptothecin. The in vivo antitumor effect was further confirmed by study of tumor inhibition and positive apoptosis activity. Surface modification of lipophilic nanoparticles with PEG increased the efficiency of drug delivery into tumor tissue and subsequently more effective antitumor activity. This specific design of a chemotherapeutic agent using nanotechnology is important in the development of a safe and effective drug in cancer therapy.en_HK
dc.languageengen_US
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=5-
dc.relation.ispartofInternational journal of nanomedicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEnhancement of anticancer efficacy using modified lipophilic nanoparticle drug encapsulation.en_HK
dc.typeArticleen_HK
dc.identifier.emailWong, KK: kkywong@hkucc.hku.hken_HK
dc.identifier.authorityWong, KK=rp01392en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/IJN.S28783-
dc.identifier.pmid22359452-
dc.identifier.pmcidPMC3282612-
dc.identifier.scopuseid_2-s2.0-84862335613en_HK
dc.identifier.hkuros199742en_US
dc.identifier.volume7en_HK
dc.identifier.spage731en_HK
dc.identifier.epage737en_HK
dc.identifier.isiWOS:000302715500001-
dc.publisher.placeNew Zealand-
dc.identifier.scopusauthoridLee, P=8212119000en_HK
dc.identifier.scopusauthoridZhang, R=45261666800en_HK
dc.identifier.scopusauthoridLi, V=55253800500en_HK
dc.identifier.scopusauthoridLiu, X=37461750900en_HK
dc.identifier.scopusauthoridSun, RW=55253605200en_HK
dc.identifier.scopusauthoridChe, CM=55253537600en_HK
dc.identifier.scopusauthoridWong, KK=24438686400en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats