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Article: Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis

TitlePolysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis
Authors
KeywordsCorticosterone
Lycium extract
Polysaccharide
Animal experiment
Animal tissue
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2012, v. 7 n. 4 How to Cite?
Abstract
Lycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of infertility and sexual dysfunction. However, there is still a scarcity of experimental evidence to support the pro-sexual effect of wolfberry. The aim of this study is to determine the effect of Lycium barbarum polysaccharides (LBP) on male sexual behavior of rats. Here we report that oral feeding of LBP for 21 days significantly improved the male copulatory performance including increase of copulatory efficiency, increase of ejaculation frequency and shortening of ejaculation latency. Furthermore, sexual inhibition caused by chronic corticosterone was prevented by LBP. Simultaneously, corticosterone suppressed neurogenesis in subventricular zone and hippocampus in adult rats, which could be reversed by LBP. The neurogenic effect of LBP was also shown in vitro. Significant correlation was found between neurogenesis and sexual performance, suggesting that the newborn neurons are associated with reproductive successfulness. Blocking neurogenesis in male rats abolished the pro-sexual effect of LBP. Taken together, these results demonstrate the pro-sexual effect of LBP on normal and sexually-inhibited rats, and LBP may modulate sexual behavior by regulating neurogenesis. © 2012 Lau et al.
Persistent Identifierhttp://hdl.handle.net/10722/146846
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorLee, JCDen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorFung, SMYen_HK
dc.contributor.authorSang, YHen_HK
dc.contributor.authorShen, Jen_HK
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2012-05-23T05:42:31Z-
dc.date.available2012-05-23T05:42:31Z-
dc.date.issued2012en_HK
dc.identifier.citationPlos One, 2012, v. 7 n. 4en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146846-
dc.description.abstractLycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of infertility and sexual dysfunction. However, there is still a scarcity of experimental evidence to support the pro-sexual effect of wolfberry. The aim of this study is to determine the effect of Lycium barbarum polysaccharides (LBP) on male sexual behavior of rats. Here we report that oral feeding of LBP for 21 days significantly improved the male copulatory performance including increase of copulatory efficiency, increase of ejaculation frequency and shortening of ejaculation latency. Furthermore, sexual inhibition caused by chronic corticosterone was prevented by LBP. Simultaneously, corticosterone suppressed neurogenesis in subventricular zone and hippocampus in adult rats, which could be reversed by LBP. The neurogenic effect of LBP was also shown in vitro. Significant correlation was found between neurogenesis and sexual performance, suggesting that the newborn neurons are associated with reproductive successfulness. Blocking neurogenesis in male rats abolished the pro-sexual effect of LBP. Taken together, these results demonstrate the pro-sexual effect of LBP on normal and sexually-inhibited rats, and LBP may modulate sexual behavior by regulating neurogenesis. © 2012 Lau et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCorticosterone-
dc.subjectLycium extract-
dc.subjectPolysaccharide-
dc.subjectAnimal experiment-
dc.subjectAnimal tissue-
dc.titlePolysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailShen, J: shenjg@hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0033374en_HK
dc.identifier.pmid22523540-
dc.identifier.pmcidPMC3327693-
dc.identifier.scopuseid_2-s2.0-84859807658en_HK
dc.identifier.hkuros199683en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859807658&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.isiWOS:000305345000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridLee, JCD=55020582400en_HK
dc.identifier.scopusauthoridLi, Y=36671636100en_HK
dc.identifier.scopusauthoridFung, SMY=55189149100en_HK
dc.identifier.scopusauthoridSang, YH=55190293900en_HK
dc.identifier.scopusauthoridShen, J=7404929947en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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