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Article: Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis
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TitlePolysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis
 
AuthorsLau, BWM1 2
Lee, JCD1 2
Li, Y2
Fung, SMY1
Sang, YH1
Shen, J2
Chang, RCC1 2
So, KF1 2
 
KeywordsCorticosterone
Lycium extract
Polysaccharide
Animal experiment
Animal tissue
 
Issue Date2012
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPlos One, 2012, v. 7 n. 4 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0033374
 
AbstractLycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of infertility and sexual dysfunction. However, there is still a scarcity of experimental evidence to support the pro-sexual effect of wolfberry. The aim of this study is to determine the effect of Lycium barbarum polysaccharides (LBP) on male sexual behavior of rats. Here we report that oral feeding of LBP for 21 days significantly improved the male copulatory performance including increase of copulatory efficiency, increase of ejaculation frequency and shortening of ejaculation latency. Furthermore, sexual inhibition caused by chronic corticosterone was prevented by LBP. Simultaneously, corticosterone suppressed neurogenesis in subventricular zone and hippocampus in adult rats, which could be reversed by LBP. The neurogenic effect of LBP was also shown in vitro. Significant correlation was found between neurogenesis and sexual performance, suggesting that the newborn neurons are associated with reproductive successfulness. Blocking neurogenesis in male rats abolished the pro-sexual effect of LBP. Taken together, these results demonstrate the pro-sexual effect of LBP on normal and sexually-inhibited rats, and LBP may modulate sexual behavior by regulating neurogenesis. © 2012 Lau et al.
 
ISSN1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0033374
 
PubMed Central IDPMC3327693
 
ISI Accession Number IDWOS:000305345000009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLau, BWM
 
dc.contributor.authorLee, JCD
 
dc.contributor.authorLi, Y
 
dc.contributor.authorFung, SMY
 
dc.contributor.authorSang, YH
 
dc.contributor.authorShen, J
 
dc.contributor.authorChang, RCC
 
dc.contributor.authorSo, KF
 
dc.date.accessioned2012-05-23T05:42:31Z
 
dc.date.available2012-05-23T05:42:31Z
 
dc.date.issued2012
 
dc.description.abstractLycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of infertility and sexual dysfunction. However, there is still a scarcity of experimental evidence to support the pro-sexual effect of wolfberry. The aim of this study is to determine the effect of Lycium barbarum polysaccharides (LBP) on male sexual behavior of rats. Here we report that oral feeding of LBP for 21 days significantly improved the male copulatory performance including increase of copulatory efficiency, increase of ejaculation frequency and shortening of ejaculation latency. Furthermore, sexual inhibition caused by chronic corticosterone was prevented by LBP. Simultaneously, corticosterone suppressed neurogenesis in subventricular zone and hippocampus in adult rats, which could be reversed by LBP. The neurogenic effect of LBP was also shown in vitro. Significant correlation was found between neurogenesis and sexual performance, suggesting that the newborn neurons are associated with reproductive successfulness. Blocking neurogenesis in male rats abolished the pro-sexual effect of LBP. Taken together, these results demonstrate the pro-sexual effect of LBP on normal and sexually-inhibited rats, and LBP may modulate sexual behavior by regulating neurogenesis. © 2012 Lau et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos One, 2012, v. 7 n. 4 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0033374
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0033374
 
dc.identifier.hkuros199683
 
dc.identifier.isiWOS:000305345000009
 
dc.identifier.issn1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
dc.identifier.issue4
 
dc.identifier.pmcidPMC3327693
 
dc.identifier.pmid22523540
 
dc.identifier.scopuseid_2-s2.0-84859807658
 
dc.identifier.urihttp://hdl.handle.net/10722/146846
 
dc.identifier.volume7
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS ONE
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectCorticosterone
 
dc.subjectLycium extract
 
dc.subjectPolysaccharide
 
dc.subjectAnimal experiment
 
dc.subjectAnimal tissue
 
dc.titlePolysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis
 
dc.typeArticle
 
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<contributor.author>Lee, JCD</contributor.author>
<contributor.author>Li, Y</contributor.author>
<contributor.author>Fung, SMY</contributor.author>
<contributor.author>Sang, YH</contributor.author>
<contributor.author>Shen, J</contributor.author>
<contributor.author>Chang, RCC</contributor.author>
<contributor.author>So, KF</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong