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Article: An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart

TitleAn ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart
Authors
KeywordsOntogeny
Lung
Kidney
Heart
Adrenomedullin
Adrenal
Issue Date2012
PublisherHumana Press, Inc.
Citation
Endocrine, 2012, v. 41 n. 2, p. 256-265 How to Cite?
AbstractIn this study, the gene expression of adrenomedullin (Adm) in the peripheral tissues which include lung, adrenal, kidney, and heart during development was investigated in the rat. The preproadrenomedullin (preproAdm) mRNA and mRNAs of its related receptor components, calcitonin receptor-like receptor (Crlr), and receptor activity-modifying proteins (Ramp1, 2 and 3) of the lung, adrenal, kidney, and heart were measured by real-time RT-PCR and the ADM peptide measured by radioimmunoassay in 1-, 7-, 21-day-old rats and the adult rats. From day 1 to 21, preproAdm mRNA levels increased with age in the lung, the kidney, and the heart but decreased with age in the adrenal. ADM levels, however, increased with age in the lung but decreased with age in the kidney, the adrenal, and the heart. The preproAdm levels in the lung, in the kidney, and in the adrenal all increased in the adult rat. ADM peptide levels, however, decreased in the adult rat. Crlr and Ramp2 gene expression increased with age in the lung, in the kidney, and in the heart but decreased with age in the adrenal in the prepubertal rats. The results indicate that the levels of preproAdm mRNA, ADM peptide and its receptor component mRNAs in different tissues followed different patterns of changes during development. © 2012 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/146842
ISSN
2015 Impact Factor: 3.279
ISI Accession Number ID
Funding AgencyGrant Number
Committee o Research and Conference Grants (CRCG) of the University of Hong Kong
Funding Information:

This study was supported by a grant from the Committee o Research and Conference Grants (CRCG) of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, PFen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2012-05-23T05:42:29Z-
dc.date.available2012-05-23T05:42:29Z-
dc.date.issued2012en_HK
dc.identifier.citationEndocrine, 2012, v. 41 n. 2, p. 256-265en_HK
dc.identifier.issn1355-008Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146842-
dc.description.abstractIn this study, the gene expression of adrenomedullin (Adm) in the peripheral tissues which include lung, adrenal, kidney, and heart during development was investigated in the rat. The preproadrenomedullin (preproAdm) mRNA and mRNAs of its related receptor components, calcitonin receptor-like receptor (Crlr), and receptor activity-modifying proteins (Ramp1, 2 and 3) of the lung, adrenal, kidney, and heart were measured by real-time RT-PCR and the ADM peptide measured by radioimmunoassay in 1-, 7-, 21-day-old rats and the adult rats. From day 1 to 21, preproAdm mRNA levels increased with age in the lung, the kidney, and the heart but decreased with age in the adrenal. ADM levels, however, increased with age in the lung but decreased with age in the kidney, the adrenal, and the heart. The preproAdm levels in the lung, in the kidney, and in the adrenal all increased in the adult rat. ADM peptide levels, however, decreased in the adult rat. Crlr and Ramp2 gene expression increased with age in the lung, in the kidney, and in the heart but decreased with age in the adrenal in the prepubertal rats. The results indicate that the levels of preproAdm mRNA, ADM peptide and its receptor component mRNAs in different tissues followed different patterns of changes during development. © 2012 Springer Science+Business Media, LLC.en_HK
dc.languageengen_US
dc.publisherHumana Press, Inc.-
dc.relation.ispartofEndocrineen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectOntogenyen_HK
dc.subjectLungen_HK
dc.subjectKidneyen_HK
dc.subjectHearten_HK
dc.subjectAdrenomedullinen_HK
dc.subjectAdrenalen_HK
dc.subject.meshAdrenal glands - growth and development - metabolism-
dc.subject.meshAdrenomedullin - genetics - metabolism-
dc.subject.meshCalcitonin receptor-like protein - genetics - metabolism-
dc.subject.meshGene expression regulation, Developmental-
dc.subject.meshKidney - growth and development - metabolism-
dc.subject.meshAnimals, Newborn-
dc.subject.meshHeart - growth and development-
dc.subject.meshLung - growth and development - metabolism-
dc.subject.meshMyocardium - metabolism-
dc.subject.meshOrgan specificity-
dc.subject.meshProtein isoforms - genetics - metabolism-
dc.subject.meshProtein precursors - genetics-
dc.titleAn ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and hearten_HK
dc.typeArticleen_HK
dc.identifier.emailWong, PF: pfwong@hku.hken_HK
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_HK
dc.identifier.emailTang, F: ftang@hku.hk-
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12020-011-9552-4en_HK
dc.identifier.pmid22042486-
dc.identifier.scopuseid_2-s2.0-84862637150en_HK
dc.identifier.hkuros199502en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862637150&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue2en_HK
dc.identifier.spage256en_HK
dc.identifier.epage265en_HK
dc.identifier.isiWOS:000303584800012-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridWong, PF=53880614500en_HK
dc.identifier.citeulike9986550-

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