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Article: Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

TitleLuminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients
Authors
KeywordsMultifocal electroretinogram
Global flash
Asymmetric glaucoma
Ocular hypertension
Adaptive index
Issue Date2012
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm
Citation
Graefe's Archive for Clinical and Experimental Ophthalmology, 2012, v. 250 n. 2, p. 261-270 How to Cite?
AbstractPURPOSE: To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. METHODS: Eighteen subjects (28 eyes) with asymmetric glaucoma and ocular hypertension were measured in this longitudinal study of visual field, OCT, and multifocal electroretinogram (mfERG). Five ophthalmic examinations were scheduled, once every 12 months over a 4-year period. The mfERG was assessed using a luminance-modulated global flash stimulation paradigm. The adaptive index which we have reported previously was calculated. RESULTS: There was a significant thinning of the peripapillary retinal nerve fiber layer over the course of the study for eyes with ocular hypertension, or for fellow eyes with asymmetric glaucoma which initially had an abnormal adaptive index; such eyes showed a thinning rate of -3.59 and -3.69 mum/year, respectively. However, no significant thinning was found for eyes which initially had a normal adaptive index. Two subjects were shown to have glaucomatous damage, confirmed by abnormal thinning of the retinal nerve fiber layer and visual field loss respectively at the last visit. However, these patients had shown an abnormal adaptive index in the mfERG measurement at the first visit. CONCLUSIONS: The adaptive index calculated from the measurement of luminance-modulated global flash mfERG is useful for predicting progression of signs related to glaucoma, especially in high-risk groups. The abnormal adaptive index reflects the change in fast-adaptive mechanisms in the retina and indicates the risk of developing glaucoma. © Springer-Verlag 2011.
Persistent Identifierhttp://hdl.handle.net/10722/146841
ISSN
2015 Impact Factor: 1.991
2015 SCImago Journal Rankings: 1.217
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Committee of the Hong Kong SARPolyU 5384/04 M
Hong Kong Polytechnic UniversityJ-BB76
G-YX3C
Funding Information:

This study was supported by the Competitive Earmark Research Grant (PolyU 5384/04 M) from The Research Grants Committee of the Hong Kong SAR, the Grants for Post-Doctoral Fellowship (G-YX3C) and the Niche Areas - Glaucoma Research (J-BB76) from The Hong Kong Polytechnic University.

References

 

DC FieldValueLanguage
dc.contributor.authorChu, PHWen_HK
dc.contributor.authorNg, YFen_HK
dc.contributor.authorTo, CHen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorBrown, Ben_HK
dc.contributor.authorChan, HHLen_HK
dc.date.accessioned2012-05-23T05:42:29Z-
dc.date.available2012-05-23T05:42:29Z-
dc.date.issued2012en_HK
dc.identifier.citationGraefe's Archive for Clinical and Experimental Ophthalmology, 2012, v. 250 n. 2, p. 261-270en_HK
dc.identifier.issn0721-832Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146841-
dc.description.abstractPURPOSE: To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. METHODS: Eighteen subjects (28 eyes) with asymmetric glaucoma and ocular hypertension were measured in this longitudinal study of visual field, OCT, and multifocal electroretinogram (mfERG). Five ophthalmic examinations were scheduled, once every 12 months over a 4-year period. The mfERG was assessed using a luminance-modulated global flash stimulation paradigm. The adaptive index which we have reported previously was calculated. RESULTS: There was a significant thinning of the peripapillary retinal nerve fiber layer over the course of the study for eyes with ocular hypertension, or for fellow eyes with asymmetric glaucoma which initially had an abnormal adaptive index; such eyes showed a thinning rate of -3.59 and -3.69 mum/year, respectively. However, no significant thinning was found for eyes which initially had a normal adaptive index. Two subjects were shown to have glaucomatous damage, confirmed by abnormal thinning of the retinal nerve fiber layer and visual field loss respectively at the last visit. However, these patients had shown an abnormal adaptive index in the mfERG measurement at the first visit. CONCLUSIONS: The adaptive index calculated from the measurement of luminance-modulated global flash mfERG is useful for predicting progression of signs related to glaucoma, especially in high-risk groups. The abnormal adaptive index reflects the change in fast-adaptive mechanisms in the retina and indicates the risk of developing glaucoma. © Springer-Verlag 2011.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htmen_HK
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMultifocal electroretinogram-
dc.subjectGlobal flash-
dc.subjectAsymmetric glaucoma-
dc.subjectOcular hypertension-
dc.subjectAdaptive index-
dc.subject.meshVisual Fields - physiologyen_HK
dc.subject.meshVisual Acuity - physiologyen_HK
dc.subject.meshVision Disorders - physiopathologyen_HK
dc.subject.meshTonometry, Ocularen_HK
dc.subject.meshTomography, Optical Coherenceen_HK
dc.subject.meshRetinal Ganglion Cells - pathologyen_HK
dc.subject.meshRetina - physiopathologyen_HK
dc.subject.meshPhotic Stimulationen_HK
dc.subject.meshOcular Hypertension - drug therapy - physiopathologyen_HK
dc.subject.meshNerve Fibers - pathologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshIntraocular Pressure - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshGlaucoma, Open-Angle - drug therapy - physiopathologyen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.titleLuminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.emailChan, HHL: henryhl.chan@polyu.edu.hk-
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00417-011-1790-xen_HK
dc.identifier.pmid21881844-
dc.identifier.scopuseid_2-s2.0-84857371949en_HK
dc.identifier.hkuros199493en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857371949&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume250en_HK
dc.identifier.issue2en_HK
dc.identifier.spage261en_HK
dc.identifier.epage270en_HK
dc.identifier.isiWOS:000300290600013-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChan, HHL=55017439000en_HK
dc.identifier.scopusauthoridBrown, B=7404161499en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridTo, CH=55017436500en_HK
dc.identifier.scopusauthoridNg, YF=23989024100en_HK
dc.identifier.scopusauthoridChu, PHW=9243174200en_HK
dc.identifier.citeulike9768644-

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