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- Publisher Website: 10.1007/s00417-011-1790-x
- Scopus: eid_2-s2.0-84857371949
- PMID: 21881844
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Article: Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients
Title | Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients | ||||||||
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Authors | |||||||||
Keywords | Multifocal electroretinogram Global flash Asymmetric glaucoma Ocular hypertension Adaptive index | ||||||||
Issue Date | 2012 | ||||||||
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm | ||||||||
Citation | Graefe's Archive for Clinical and Experimental Ophthalmology, 2012, v. 250 n. 2, p. 261-270 How to Cite? | ||||||||
Abstract | PURPOSE: To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. METHODS: Eighteen subjects (28 eyes) with asymmetric glaucoma and ocular hypertension were measured in this longitudinal study of visual field, OCT, and multifocal electroretinogram (mfERG). Five ophthalmic examinations were scheduled, once every 12 months over a 4-year period. The mfERG was assessed using a luminance-modulated global flash stimulation paradigm. The adaptive index which we have reported previously was calculated. RESULTS: There was a significant thinning of the peripapillary retinal nerve fiber layer over the course of the study for eyes with ocular hypertension, or for fellow eyes with asymmetric glaucoma which initially had an abnormal adaptive index; such eyes showed a thinning rate of -3.59 and -3.69 mum/year, respectively. However, no significant thinning was found for eyes which initially had a normal adaptive index. Two subjects were shown to have glaucomatous damage, confirmed by abnormal thinning of the retinal nerve fiber layer and visual field loss respectively at the last visit. However, these patients had shown an abnormal adaptive index in the mfERG measurement at the first visit. CONCLUSIONS: The adaptive index calculated from the measurement of luminance-modulated global flash mfERG is useful for predicting progression of signs related to glaucoma, especially in high-risk groups. The abnormal adaptive index reflects the change in fast-adaptive mechanisms in the retina and indicates the risk of developing glaucoma. © Springer-Verlag 2011. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/146841 | ||||||||
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 1.014 | ||||||||
ISI Accession Number ID |
Funding Information: This study was supported by the Competitive Earmark Research Grant (PolyU 5384/04 M) from The Research Grants Committee of the Hong Kong SAR, the Grants for Post-Doctoral Fellowship (G-YX3C) and the Niche Areas - Glaucoma Research (J-BB76) from The Hong Kong Polytechnic University. | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chu, PHW | en_HK |
dc.contributor.author | Ng, YF | en_HK |
dc.contributor.author | To, CH | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.contributor.author | Brown, B | en_HK |
dc.contributor.author | Chan, HHL | en_HK |
dc.date.accessioned | 2012-05-23T05:42:29Z | - |
dc.date.available | 2012-05-23T05:42:29Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Graefe's Archive for Clinical and Experimental Ophthalmology, 2012, v. 250 n. 2, p. 261-270 | en_HK |
dc.identifier.issn | 0721-832X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/146841 | - |
dc.description.abstract | PURPOSE: To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. METHODS: Eighteen subjects (28 eyes) with asymmetric glaucoma and ocular hypertension were measured in this longitudinal study of visual field, OCT, and multifocal electroretinogram (mfERG). Five ophthalmic examinations were scheduled, once every 12 months over a 4-year period. The mfERG was assessed using a luminance-modulated global flash stimulation paradigm. The adaptive index which we have reported previously was calculated. RESULTS: There was a significant thinning of the peripapillary retinal nerve fiber layer over the course of the study for eyes with ocular hypertension, or for fellow eyes with asymmetric glaucoma which initially had an abnormal adaptive index; such eyes showed a thinning rate of -3.59 and -3.69 mum/year, respectively. However, no significant thinning was found for eyes which initially had a normal adaptive index. Two subjects were shown to have glaucomatous damage, confirmed by abnormal thinning of the retinal nerve fiber layer and visual field loss respectively at the last visit. However, these patients had shown an abnormal adaptive index in the mfERG measurement at the first visit. CONCLUSIONS: The adaptive index calculated from the measurement of luminance-modulated global flash mfERG is useful for predicting progression of signs related to glaucoma, especially in high-risk groups. The abnormal adaptive index reflects the change in fast-adaptive mechanisms in the retina and indicates the risk of developing glaucoma. © Springer-Verlag 2011. | en_HK |
dc.language | eng | en_US |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm | en_HK |
dc.relation.ispartof | Graefe's Archive for Clinical and Experimental Ophthalmology | en_HK |
dc.rights | The original publication is available at www.springerlink.com | - |
dc.subject | Multifocal electroretinogram | - |
dc.subject | Global flash | - |
dc.subject | Asymmetric glaucoma | - |
dc.subject | Ocular hypertension | - |
dc.subject | Adaptive index | - |
dc.subject.mesh | Visual Fields - physiology | en_HK |
dc.subject.mesh | Visual Acuity - physiology | en_HK |
dc.subject.mesh | Vision Disorders - physiopathology | en_HK |
dc.subject.mesh | Tonometry, Ocular | en_HK |
dc.subject.mesh | Tomography, Optical Coherence | en_HK |
dc.subject.mesh | Retinal Ganglion Cells - pathology | en_HK |
dc.subject.mesh | Retina - physiopathology | en_HK |
dc.subject.mesh | Photic Stimulation | en_HK |
dc.subject.mesh | Ocular Hypertension - drug therapy - physiopathology | en_HK |
dc.subject.mesh | Nerve Fibers - pathology | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Intraocular Pressure - physiology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Glaucoma, Open-Angle - drug therapy - physiopathology | en_HK |
dc.subject.mesh | Follow-Up Studies | en_HK |
dc.title | Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | So, KF: hrmaskf@hku.hk | en_HK |
dc.identifier.email | Chan, HHL: henryhl.chan@polyu.edu.hk | - |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00417-011-1790-x | en_HK |
dc.identifier.pmid | 21881844 | - |
dc.identifier.scopus | eid_2-s2.0-84857371949 | en_HK |
dc.identifier.hkuros | 199493 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84857371949&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 250 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 261 | en_HK |
dc.identifier.epage | 270 | en_HK |
dc.identifier.isi | WOS:000300290600013 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Chan, HHL=55017439000 | en_HK |
dc.identifier.scopusauthorid | Brown, B=7404161499 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.scopusauthorid | To, CH=55017436500 | en_HK |
dc.identifier.scopusauthorid | Ng, YF=23989024100 | en_HK |
dc.identifier.scopusauthorid | Chu, PHW=9243174200 | en_HK |
dc.identifier.citeulike | 9768644 | - |
dc.identifier.issnl | 0721-832X | - |