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Article: Postnatal development of NADPH-diaphorase expression in the visual cortex of the golden hamster

TitlePostnatal development of NADPH-diaphorase expression in the visual cortex of the golden hamster
Authors
KeywordsArea 17
Golden hamster
NADPH-diaphorase
Neural regeneration
Nitric oxide synthase
Postnatal development
Visual cortex
Issue Date2011
PublisherMedknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/
Citation
Neural Regeneration Research, 2011, v. 6 n. 28, p. 2165-2170 How to Cite?
AbstractNitric oxide is an important neuromodulator in the brain and is involved in the development of visual system. But it is not clear how nitric oxide and nitric oxide synthase (NOS) are involved in the developing visual cortex of rodents. Thus we examined the expression of NOS activity in the postnatal developing visual cortex of the golden hamster by using histochemical technique for NADPH-diaphorase (NADPH-d). A heavily stained NADPH-d band was observed in the neuropil of the visual cortex. This NADPH-d band initially appeared in the cortical plate from the day of birth (P0) to postnatal day 4 (P4). From P7 to P21, this band was confined to area 17 and migrated to the deeper layers III-IV and V-VI before it eventually disappeared at P28. Such developmental trends of the band correlated well with the process of formation and establishment of the geniculo-cortical projection patterns. Thus, the areal specific development of the band suggests that NOS is closely related to the cortical differentiation and synaptic formation of the primary visual cortex. On the other hand, monocular eye enucleation on P1 could not alter the appearance of this NADPH-d positive band, indicating a non-activity dependant role of NOS. In addition, differences in the laminar distributions and developmental sequence between the heavily and lightly stained NADPH-d positive neurons during development suggest that they play different roles in the development.
Persistent Identifierhttp://hdl.handle.net/10722/146837
ISSN
2015 Impact Factor: 0.968
2015 SCImago Journal Rankings: 0.337
ISI Accession Number ID
Funding AgencyGrant Number
Fundamental Research Funds for the Central Universities21609101
National Basic Research Program of China (973 Program)2011CB707501
Funding Information:

The work was supported by the Fundamental Research Funds for the Central Universities, No. 21609101, and the National Basic Research Program of China (973 Program), No. 2011CB707501.

References

 

DC FieldValueLanguage
dc.contributor.authorXu, Yen_HK
dc.contributor.authorXiao, Yen_HK
dc.contributor.authorDiao, Yen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2012-05-23T05:42:26Z-
dc.date.available2012-05-23T05:42:26Z-
dc.date.issued2011en_HK
dc.identifier.citationNeural Regeneration Research, 2011, v. 6 n. 28, p. 2165-2170en_HK
dc.identifier.issn1673-5374en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146837-
dc.description.abstractNitric oxide is an important neuromodulator in the brain and is involved in the development of visual system. But it is not clear how nitric oxide and nitric oxide synthase (NOS) are involved in the developing visual cortex of rodents. Thus we examined the expression of NOS activity in the postnatal developing visual cortex of the golden hamster by using histochemical technique for NADPH-diaphorase (NADPH-d). A heavily stained NADPH-d band was observed in the neuropil of the visual cortex. This NADPH-d band initially appeared in the cortical plate from the day of birth (P0) to postnatal day 4 (P4). From P7 to P21, this band was confined to area 17 and migrated to the deeper layers III-IV and V-VI before it eventually disappeared at P28. Such developmental trends of the band correlated well with the process of formation and establishment of the geniculo-cortical projection patterns. Thus, the areal specific development of the band suggests that NOS is closely related to the cortical differentiation and synaptic formation of the primary visual cortex. On the other hand, monocular eye enucleation on P1 could not alter the appearance of this NADPH-d positive band, indicating a non-activity dependant role of NOS. In addition, differences in the laminar distributions and developmental sequence between the heavily and lightly stained NADPH-d positive neurons during development suggest that they play different roles in the development.en_HK
dc.languageengen_US
dc.publisherMedknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.nrronline.org/en_HK
dc.relation.ispartofNeural Regeneration Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectArea 17en_HK
dc.subjectGolden hamsteren_HK
dc.subjectNADPH-diaphoraseen_HK
dc.subjectNeural regenerationen_HK
dc.subjectNitric oxide synthaseen_HK
dc.subjectPostnatal developmenten_HK
dc.subjectVisual cortexen_HK
dc.titlePostnatal development of NADPH-diaphorase expression in the visual cortex of the golden hamsteren_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3969/j.issn.1673-5374.2011.28.001en_HK
dc.identifier.scopuseid_2-s2.0-81755182770en_HK
dc.identifier.hkuros199430en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81755182770&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue28en_HK
dc.identifier.spage2165en_HK
dc.identifier.epage2170en_HK
dc.identifier.isiWOS:000297305200001-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridXu, Y=54401858800en_HK
dc.identifier.scopusauthoridXiao, Y=7403260801en_HK
dc.identifier.scopusauthoridDiao, Y=7004284577en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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