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Article: Effects of a single topical doxycycline administration adjunctive to mechanical debridement in patients with persistent/recurrent periodontitis but acceptable oral hygiene during supportive periodontal therapy

TitleEffects of a single topical doxycycline administration adjunctive to mechanical debridement in patients with persistent/recurrent periodontitis but acceptable oral hygiene during supportive periodontal therapy
Authors
KeywordsDoxycycline
Local antibiotics
Mechanical debridement
Recurrent periodontitis
Slow release
Issue Date2012
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal of Clinical Periodontology, 2012, v. 39 n. 5, p. 475-482 How to Cite?
AbstractOBJECTIVES: To evaluate the efficacy of a slow release doxycycline gel (SRD) adjunctively administered to non-surgical therapy in subjects with recurrent or persistent periodontitis but acceptable oral hygiene during supportive periodontal care. MATERIAL and METHODS: In this single blind, parallel group, multicentre study, 202 of 203 recruited periodontal maintenance subjects with recurrent or persistent periodontitis were randomly assigned to subgingival ultrasonic/sonic instrumentation (USI) with (test) or without (control) subsequent administration of SRD in all residual periodontal pockets >/=4 mm. Intergroup differences in probing depth, BOP reductions, treatment time, probing attachment levels were evaluated at 3, 6 and 12 months. The primary outcome was the inter-group difference in absolute change of probing pocket depth (PPD) 3, 6 and 12 months after intervention. RESULTS: At baseline, the two groups were comparable. At 3 months, the test group showed a significantly higher decrease in mean probing depth than the control group at 3 months (mean difference = 0.11 mm, 95% CI 0.03-0.19 mm, p = 0.003). Administration of SRD resulted in significantly greater odds of transition of bleeding pockets >/=5 mm to a category of non bleeding sites with PPD /=2 mm) and were exited from the study. No difference in the incidence of adverse events was observed between groups. CONCLUSION: The trial results show that topically administered SRD may provide short-term benefit in controlling inflammation and deep pockets in treated periodontal patients participating in a secondary prevention programme and able to maintain a satisfactory level of oral hygiene.
Persistent Identifierhttp://hdl.handle.net/10722/146826
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
Funding AgencyGrant Number
European Research Group on Periodontology (ERGOPerio)
IVOCLAR Vivadent, Schaan, Liechtenstein
Funding Information:

This investigator initiated study has been supported by the European Research Group on Periodontology (ERGOPerio) with an unrestricted grant from IVOCLAR Vivadent, Schaan, Liechtenstein. The doxycycline gel was provided by IVOCLAR Vivadent, Schaan, Liechtenstein. The authors were fully independent in preparing the protocol, conducting the research, interpreting the results and preparing the final manuscript. The authors declare no conflict of interest.

 

DC FieldValueLanguage
dc.contributor.authorTonetti, MSen_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorCortellini, Pen_US
dc.contributor.authorSuvan, JEen_US
dc.contributor.authorEickholz, Pen_US
dc.contributor.authorFourmousis, Ien_US
dc.contributor.authorTopoll, Hen_US
dc.contributor.authorVangsted, Ten_US
dc.contributor.authorWallkamm, Ben_US
dc.contributor.authorEuropean Research Group on Periodontology(ERGOPerio)-
dc.date.accessioned2012-05-23T05:28:05Z-
dc.date.available2012-05-23T05:28:05Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Clinical Periodontology, 2012, v. 39 n. 5, p. 475-482en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/146826-
dc.description.abstractOBJECTIVES: To evaluate the efficacy of a slow release doxycycline gel (SRD) adjunctively administered to non-surgical therapy in subjects with recurrent or persistent periodontitis but acceptable oral hygiene during supportive periodontal care. MATERIAL and METHODS: In this single blind, parallel group, multicentre study, 202 of 203 recruited periodontal maintenance subjects with recurrent or persistent periodontitis were randomly assigned to subgingival ultrasonic/sonic instrumentation (USI) with (test) or without (control) subsequent administration of SRD in all residual periodontal pockets >/=4 mm. Intergroup differences in probing depth, BOP reductions, treatment time, probing attachment levels were evaluated at 3, 6 and 12 months. The primary outcome was the inter-group difference in absolute change of probing pocket depth (PPD) 3, 6 and 12 months after intervention. RESULTS: At baseline, the two groups were comparable. At 3 months, the test group showed a significantly higher decrease in mean probing depth than the control group at 3 months (mean difference = 0.11 mm, 95% CI 0.03-0.19 mm, p = 0.003). Administration of SRD resulted in significantly greater odds of transition of bleeding pockets >/=5 mm to a category of non bleeding sites with PPD </=4 mm at 3 and 6 months (O.R. = 1.4, 95% CI 1.2-1.8 at 3 months). At 6 months, SRD benefit was observed only in the deeper pockets. 7.5% of subjects (no significant difference between test and control) showed disease progression (attachment loss >/=2 mm) and were exited from the study. No difference in the incidence of adverse events was observed between groups. CONCLUSION: The trial results show that topically administered SRD may provide short-term benefit in controlling inflammation and deep pockets in treated periodontal patients participating in a secondary prevention programme and able to maintain a satisfactory level of oral hygiene.-
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_US
dc.subjectDoxycycline-
dc.subjectLocal antibiotics-
dc.subjectMechanical debridement-
dc.subjectRecurrent periodontitis-
dc.subjectSlow release-
dc.titleEffects of a single topical doxycycline administration adjunctive to mechanical debridement in patients with persistent/recurrent periodontitis but acceptable oral hygiene during supportive periodontal therapyen_US
dc.typeArticleen_US
dc.identifier.emailLang, NP: nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2012.01864.x-
dc.identifier.pmid22429128-
dc.identifier.scopuseid_2-s2.0-84859785032-
dc.identifier.hkuros199428en_US
dc.identifier.volume39en_US
dc.identifier.issue5en_US
dc.identifier.spage475en_US
dc.identifier.epage482en_US
dc.identifier.eissn1600-051X-
dc.identifier.isiWOS:000302614300009-
dc.publisher.placeDenmarken_US

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