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Article: Vitamin D status and peripheral arterial disease: evidence so far.

TitleVitamin D status and peripheral arterial disease: evidence so far.
Authors
Issue Date2011
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=2
Citation
Vascular Health And Risk Management, 2011, v. 7, p. 671-675 How to Cite?
AbstractVitamin D deficiency has recently been implicated as a contributory factor in the development of peripheral arterial disease (PAD). A review of the published literature on PAD and vitamin D was undertaken using Medline, PubMed, and Embase, and cross-referenced. All relevant published papers on the subject were reviewed. Published studies have shown that there is a significant association between vitamin D and PAD. Populations with lower vitamin D levels are more likely to develop PAD in a graded manner. Higher amputation rates are also observed among patients with PAD and lower vitamin D levels. In addition, vitamin D deficiency is significantly associated with increased risk of cardiovascular adverse events. This was also observed in the mouse model where low vitamin D led to the development of atherosclerosis. This study shows that vitamin D deficiency could be an independent risk factor for the development of PAD and that this risk factor is easily correctable. Further studies should look into the effects of vitamin D supplementation in patients with PAD.
Persistent Identifierhttp://hdl.handle.net/10722/146821
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorChua, GTen_HK
dc.contributor.authorChan, YCen_HK
dc.contributor.authorCheng, SWen_HK
dc.date.accessioned2012-05-23T04:37:50Z-
dc.date.available2012-05-23T04:37:50Z-
dc.date.issued2011en_HK
dc.identifier.citationVascular Health And Risk Management, 2011, v. 7, p. 671-675en_HK
dc.identifier.issn1178-2048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146821-
dc.description.abstractVitamin D deficiency has recently been implicated as a contributory factor in the development of peripheral arterial disease (PAD). A review of the published literature on PAD and vitamin D was undertaken using Medline, PubMed, and Embase, and cross-referenced. All relevant published papers on the subject were reviewed. Published studies have shown that there is a significant association between vitamin D and PAD. Populations with lower vitamin D levels are more likely to develop PAD in a graded manner. Higher amputation rates are also observed among patients with PAD and lower vitamin D levels. In addition, vitamin D deficiency is significantly associated with increased risk of cardiovascular adverse events. This was also observed in the mouse model where low vitamin D led to the development of atherosclerosis. This study shows that vitamin D deficiency could be an independent risk factor for the development of PAD and that this risk factor is easily correctable. Further studies should look into the effects of vitamin D supplementation in patients with PAD.en_HK
dc.languageeng-
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=2-
dc.relation.ispartofVascular health and risk managementen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAtherosclerosis - etiology-
dc.subject.meshCardiovascular Diseases - etiology-
dc.subject.meshPeripheral Arterial Disease - etiology - surgery-
dc.subject.meshVitamin D - blood-
dc.subject.meshVitamin D Deficiency - complications-
dc.titleVitamin D status and peripheral arterial disease: evidence so far.en_HK
dc.typeArticleen_HK
dc.identifier.emailChan, YC: ycchan88@hkucc.hku.hken_HK
dc.identifier.authorityChan, YC=rp00530en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2147/VHRM.S24876-
dc.identifier.pmid22140318-
dc.identifier.pmcidPMC3225350-
dc.identifier.scopuseid_2-s2.0-84859925558en_HK
dc.identifier.hkuros198210-
dc.identifier.volume7en_HK
dc.identifier.spage671en_HK
dc.identifier.epage675en_HK
dc.publisher.placeNew Zealand-
dc.identifier.scopusauthoridChua, GT=55190642200en_HK
dc.identifier.scopusauthoridChan, YC=27170769400en_HK
dc.identifier.scopusauthoridCheng, SW=55191189700en_HK
dc.identifier.citeulike10131676-

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