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Article: Expression of a neuropeptide, endothelin-1 in pons and medulla of prenatal and perinatal mouse brains

TitleExpression of a neuropeptide, endothelin-1 in pons and medulla of prenatal and perinatal mouse brains
Authors
KeywordsBrain development
In situ hybridization
Mouse embryo
Respiratory control
Ventrolateral medulla
Issue Date2005
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00207454.asp
Citation
International Journal Of Neuroscience, 2005, v. 115 n. 11, p. 1485-1501 How to Cite?
AbstractEndothelin-1 (ET-1), a potent vasoconstrictor, is widely distributed in the central nervous system. This article demonstrates the spatio-temporal expression of mouse preproendothelin-1 (mPPET-1) gene in pre- and perinatal mouse brain by in situ hybridization using a probe specific for mPPET-1. mPPET-1 mRNA expression was first observed in medulla at embryonic age 11.5 (E11.5) and the level became increasingly stronger toward later stages of development. At E18.5 and postnatal day 0.5 (D0.5), mPPET-1 mRNA was found in discrete nucleus group in ventrolateral medulla. mPPET-1 mRNA was also detected in thalamic reticular nucleus at E16.5, E18.5, and D0.5. These results showed that mPPET-1 mRNA is present in neurons of central cardiorespiratory region and drastically increased during the transition from episodic fetal breathing to continuous postnatal respiration (E18.5 to D0.5), implicating the important role of ET-1 in central cardiorespiratory control regulating the onset of respiration during this critical period. Copyright © 2005 Taylor & Francis Inc.
Persistent Identifierhttp://hdl.handle.net/10722/146629
ISSN
2015 Impact Factor: 1.717
2015 SCImago Journal Rankings: 0.637
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, MCSen_HK
dc.contributor.authorLo, ACYen_HK
dc.contributor.authorChan, TSKen_HK
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorChung, SKen_HK
dc.date.accessioned2012-05-08T03:21:22Z-
dc.date.available2012-05-08T03:21:22Z-
dc.date.issued2005en_HK
dc.identifier.citationInternational Journal Of Neuroscience, 2005, v. 115 n. 11, p. 1485-1501en_HK
dc.identifier.issn0020-7454en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146629-
dc.description.abstractEndothelin-1 (ET-1), a potent vasoconstrictor, is widely distributed in the central nervous system. This article demonstrates the spatio-temporal expression of mouse preproendothelin-1 (mPPET-1) gene in pre- and perinatal mouse brain by in situ hybridization using a probe specific for mPPET-1. mPPET-1 mRNA expression was first observed in medulla at embryonic age 11.5 (E11.5) and the level became increasingly stronger toward later stages of development. At E18.5 and postnatal day 0.5 (D0.5), mPPET-1 mRNA was found in discrete nucleus group in ventrolateral medulla. mPPET-1 mRNA was also detected in thalamic reticular nucleus at E16.5, E18.5, and D0.5. These results showed that mPPET-1 mRNA is present in neurons of central cardiorespiratory region and drastically increased during the transition from episodic fetal breathing to continuous postnatal respiration (E18.5 to D0.5), implicating the important role of ET-1 in central cardiorespiratory control regulating the onset of respiration during this critical period. Copyright © 2005 Taylor & Francis Inc.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00207454.aspen_HK
dc.relation.ispartofInternational Journal of Neuroscienceen_HK
dc.subjectBrain developmenten_HK
dc.subjectIn situ hybridizationen_HK
dc.subjectMouse embryoen_HK
dc.subjectRespiratory controlen_HK
dc.subjectVentrolateral medullaen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Northern - Methodsen_US
dc.subject.meshEmbryo, Mammalianen_US
dc.subject.meshEndothelin-1 - Genetics - Metabolismen_US
dc.subject.meshEndothelin-2 - Genetics - Metabolismen_US
dc.subject.meshEndothelin-3 - Genetics - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Developmental - Physiologyen_US
dc.subject.meshIn Situ Hybridization - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMedulla Oblongata - Embryology - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshPons - Embryology - Metabolismen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.titleExpression of a neuropeptide, endothelin-1 in pons and medulla of prenatal and perinatal mouse brainsen_HK
dc.typeArticleen_HK
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_HK
dc.identifier.authorityLo, ACY=rp00425en_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/00207450590957746en_HK
dc.identifier.pmid16223696-
dc.identifier.scopuseid_2-s2.0-27744547463en_HK
dc.identifier.hkuros113555-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27744547463&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume115en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1485en_HK
dc.identifier.epage1501en_HK
dc.identifier.isiWOS:000233300000001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsang, MCS=9239694300en_HK
dc.identifier.scopusauthoridLo, ACY=7102780640en_HK
dc.identifier.scopusauthoridChan, TSK=7402687396en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK
dc.identifier.citeulike354282-

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