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Article: Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes

TitleComparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes
Authors
KeywordsAldose reductase
Androgen regulated vas deferens protein
Chromosomal organization
Chromosome mapping
Fibroblast growth factor regulated protein
Issue Date1999
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJB
Citation
European Journal Of Biochemistry, 1999, v. 259 n. 3, p. 726-730 How to Cite?
AbstractAldose reductase (AR), best known as the first enzyme in the polyol pathway of sugar metabolism, has been implicated in a wide variety of physiological functions and in the etiology of diabetic complications. We have determined the structures and chromosomal locations of the mouse AR gene (Aldor1) and of two genes highly homologous to Aldor1: the fibroblast growth factor regulated protein gene (Fgfrp) and the androgen regulated vas deferens protein gene (Avdp). The number of introns and their locations in the mouse Aldor1 gene are identical to those of rat and human AR genes and also to those of Fgfrp and Avdp Mouse Aldor1 gene was found to be located near the Cald1 (Caldesmon) and Ptn (Pleiotropin) loci at the proximal end of chromosome 6. The closely related genes Fgfrp and Avdp were also mapped in this region of the chromosome, suggesting that these three genes may have arisen by a gene duplication event.
Persistent Identifierhttp://hdl.handle.net/10722/146626
ISSN
2006 Impact Factor: 3.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, HTBen_HK
dc.contributor.authorJenkins, NAen_HK
dc.contributor.authorCopeland, NGen_HK
dc.contributor.authorGilbert, DJen_HK
dc.contributor.authorWinkles, JAen_HK
dc.contributor.authorLouie, HWYen_HK
dc.contributor.authorLee, FKen_HK
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorChung, SKen_HK
dc.date.accessioned2012-05-08T03:21:21Z-
dc.date.available2012-05-08T03:21:21Z-
dc.date.issued1999en_HK
dc.identifier.citationEuropean Journal Of Biochemistry, 1999, v. 259 n. 3, p. 726-730en_HK
dc.identifier.issn0014-2956en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146626-
dc.description.abstractAldose reductase (AR), best known as the first enzyme in the polyol pathway of sugar metabolism, has been implicated in a wide variety of physiological functions and in the etiology of diabetic complications. We have determined the structures and chromosomal locations of the mouse AR gene (Aldor1) and of two genes highly homologous to Aldor1: the fibroblast growth factor regulated protein gene (Fgfrp) and the androgen regulated vas deferens protein gene (Avdp). The number of introns and their locations in the mouse Aldor1 gene are identical to those of rat and human AR genes and also to those of Fgfrp and Avdp Mouse Aldor1 gene was found to be located near the Cald1 (Caldesmon) and Ptn (Pleiotropin) loci at the proximal end of chromosome 6. The closely related genes Fgfrp and Avdp were also mapped in this region of the chromosome, suggesting that these three genes may have arisen by a gene duplication event.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJBen_HK
dc.relation.ispartofEuropean Journal of Biochemistryen_HK
dc.rightsEuropean Journal of Biochemistry. Copyright © Blackwell Publishing Ltd.-
dc.subjectAldose reductaseen_HK
dc.subjectAndrogen regulated vas deferens proteinen_HK
dc.subjectChromosomal organizationen_HK
dc.subjectChromosome mappingen_HK
dc.subjectFibroblast growth factor regulated proteinen_HK
dc.subject.meshAldehyde Reductase - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosome Segregationen_US
dc.subject.meshDiabetes Mellitus - Etiologyen_US
dc.subject.meshEpidermal Growth Factoren_US
dc.subject.meshFibroblast Growth Factors - Geneticsen_US
dc.subject.meshGene Duplicationen_US
dc.subject.meshMiceen_US
dc.subject.meshProteins - Geneticsen_US
dc.subject.meshPseudogenes - Geneticsen_US
dc.subject.meshSequence Homology, Nucleic Aciden_US
dc.titleComparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genesen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, SSM:smchung@hkucc.hku.hken_HK
dc.identifier.emailChung, SK:skchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1432-1327.1999.00110.xen_HK
dc.identifier.pmid10092857-
dc.identifier.scopuseid_2-s2.0-0033083841en_HK
dc.identifier.hkuros43900-
dc.identifier.hkuros52940-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033083841&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume259en_HK
dc.identifier.issue3en_HK
dc.identifier.spage726en_HK
dc.identifier.epage730en_HK
dc.identifier.isiWOS:000078737000021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, HTB=55202560700en_HK
dc.identifier.scopusauthoridJenkins, NA=35379887700en_HK
dc.identifier.scopusauthoridCopeland, NG=35374759300en_HK
dc.identifier.scopusauthoridGilbert, DJ=7401956091en_HK
dc.identifier.scopusauthoridWinkles, JA=7004983028en_HK
dc.identifier.scopusauthoridLouie, HWY=7004064974en_HK
dc.identifier.scopusauthoridLee, FK=7403111561en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK

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