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Article: Estrogen-induced alterations in synaptic morphology in the midbrain central gray

TitleEstrogen-induced alterations in synaptic morphology in the midbrain central gray
Authors
Issue Date1988
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00221/index.htm
Citation
Experimental Brain Research, 1988, v. 69 n. 3, p. 522-530 How to Cite?
AbstractAxons of ventromedial hypothalamic (VMH) neurons have been previously shown to terminate in the midbrain central gray (MCG) (Chung et al. 1984, 1986). Since VMH synapses in this region may be involved in the mediation of estrogen-induced lordosis behavior, we examined the effect of estrogen on the morphology of synapses in the MCG. Ovariectomized adult female rats were given daily subcutaneous injections of estradiol benzoate (10 μg) or the vehicle control and after 20 days of injection, only the estrogen-treated rats showed the lordosis response. A quantitative analysis of MCG tissue from these animals demonstrates morphological changes in various synaptic parameters with estrogen treatment including: 1) an increase in the mean number of dense-cored vesicles and an increase in the number of terminals containing dense-cored vesicles, 2) an increase in the length of postsynaptic densities (PSDs), 3) an increase in the number of PSDs showing perforations, 4) an increase in the number of synapses, and 5) an increase in the number of synapses with positive synaptic curvature. No alterations in the number of subjunctional bodies were observed. The dense-cored vesicles may contain an estrogen-induced trophic factor which may function in maintaining the integrity of postsynaptic processes and cells in the MCG with which VMN endings contact (Chung et al. submitted) and/or which induces morphological changes in postsynaptic structures which facilitate the effects of estrogen on lordosis behavior.
Persistent Identifierhttp://hdl.handle.net/10722/146613
ISSN
2015 Impact Factor: 2.057
2015 SCImago Journal Rankings: 1.140
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, SKen_HK
dc.contributor.authorPfaff, DWen_HK
dc.contributor.authorCohen, RSen_HK
dc.date.accessioned2012-05-08T03:21:16Z-
dc.date.available2012-05-08T03:21:16Z-
dc.date.issued1988en_HK
dc.identifier.citationExperimental Brain Research, 1988, v. 69 n. 3, p. 522-530en_HK
dc.identifier.issn0014-4819en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146613-
dc.description.abstractAxons of ventromedial hypothalamic (VMH) neurons have been previously shown to terminate in the midbrain central gray (MCG) (Chung et al. 1984, 1986). Since VMH synapses in this region may be involved in the mediation of estrogen-induced lordosis behavior, we examined the effect of estrogen on the morphology of synapses in the MCG. Ovariectomized adult female rats were given daily subcutaneous injections of estradiol benzoate (10 μg) or the vehicle control and after 20 days of injection, only the estrogen-treated rats showed the lordosis response. A quantitative analysis of MCG tissue from these animals demonstrates morphological changes in various synaptic parameters with estrogen treatment including: 1) an increase in the mean number of dense-cored vesicles and an increase in the number of terminals containing dense-cored vesicles, 2) an increase in the length of postsynaptic densities (PSDs), 3) an increase in the number of PSDs showing perforations, 4) an increase in the number of synapses, and 5) an increase in the number of synapses with positive synaptic curvature. No alterations in the number of subjunctional bodies were observed. The dense-cored vesicles may contain an estrogen-induced trophic factor which may function in maintaining the integrity of postsynaptic processes and cells in the MCG with which VMN endings contact (Chung et al. submitted) and/or which induces morphological changes in postsynaptic structures which facilitate the effects of estrogen on lordosis behavior.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00221/index.htmen_HK
dc.relation.ispartofExperimental Brain Researchen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshEstrogens - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshPeriaqueductal Gray - Drug Effects - Ultrastructureen_US
dc.subject.meshSynapses - Drug Effects - Ultrastructureen_US
dc.subject.meshSynaptic Vesicles - Drug Effects - Ultrastructureen_US
dc.titleEstrogen-induced alterations in synaptic morphology in the midbrain central grayen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, SK:skchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3371435-
dc.identifier.scopuseid_2-s2.0-0023881106en_HK
dc.identifier.volume69en_HK
dc.identifier.issue3en_HK
dc.identifier.spage522en_HK
dc.identifier.epage530en_HK
dc.identifier.isiWOS:A1988M172000008-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK
dc.identifier.scopusauthoridPfaff, DW=36046651600en_HK
dc.identifier.scopusauthoridCohen, RS=35560739900en_HK

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