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Article: Alteration by estrogen of the nucleoli in nerve cells of the rat hypothalamus

TitleAlteration by estrogen of the nucleoli in nerve cells of the rat hypothalamus
Authors
KeywordsChromatin
Estrogen effects
Hypothalamus
Nucleoli
Rat
Ultra-structure
Ventromedial nucleus
Issue Date1984
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 1984, v. 235 n. 3, p. 485-489 How to Cite?
AbstractEstrogen is accumulated from the blood by nerve cells in the ventromedial nucleus of the hypothalamus and can facilitate female reproductive behavior by acting on this region of the brain. This cell group was examined in ovariectomized female rats, given estrogen or control treatment, by use of light and electron microscopy. A significantly greater portion of the nerve cells in the estrogen-treated animals had protuberances on their nucleolar surfaces, apparent under the light microscope. The fine structure of such protuberances included dense, aggregated material, which is shown to contain DNA by the sodium tungstate staining technique. Because increased numbers of such protuberances were found in nuclei of cells of the experimental group where previous studies demonstrated a significant increase in ultrastructural signs of biosynthetic activity, they may be associated with increased RNA synthesis. Thus, they could indicate, ultrastructurally, increased synthetic rates for RNA in nerve cells through which estrogen promotes reproductive behavior. © 1984 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/146610
ISSN
2015 Impact Factor: 2.948
2015 SCImago Journal Rankings: 1.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCohen, RSen_HK
dc.contributor.authorChung, SKen_HK
dc.contributor.authorPfaff, DWen_HK
dc.date.accessioned2012-05-08T03:21:15Z-
dc.date.available2012-05-08T03:21:15Z-
dc.date.issued1984en_HK
dc.identifier.citationCell And Tissue Research, 1984, v. 235 n. 3, p. 485-489en_HK
dc.identifier.issn0302-766Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146610-
dc.description.abstractEstrogen is accumulated from the blood by nerve cells in the ventromedial nucleus of the hypothalamus and can facilitate female reproductive behavior by acting on this region of the brain. This cell group was examined in ovariectomized female rats, given estrogen or control treatment, by use of light and electron microscopy. A significantly greater portion of the nerve cells in the estrogen-treated animals had protuberances on their nucleolar surfaces, apparent under the light microscope. The fine structure of such protuberances included dense, aggregated material, which is shown to contain DNA by the sodium tungstate staining technique. Because increased numbers of such protuberances were found in nuclei of cells of the experimental group where previous studies demonstrated a significant increase in ultrastructural signs of biosynthetic activity, they may be associated with increased RNA synthesis. Thus, they could indicate, ultrastructurally, increased synthetic rates for RNA in nerve cells through which estrogen promotes reproductive behavior. © 1984 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_HK
dc.relation.ispartofCell and Tissue Researchen_HK
dc.subjectChromatinen_HK
dc.subjectEstrogen effectsen_HK
dc.subjectHypothalamusen_HK
dc.subjectNucleolien_HK
dc.subjectRaten_HK
dc.subjectUltra-structureen_HK
dc.subjectVentromedial nucleusen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCell Nucleolus - Drug Effects - Ultrastructureen_US
dc.subject.meshEstradiol - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshRna - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshVentromedial Hypothalamic Nucleus - Anatomy & Histology - Drug Effects - Ultrastructureen_US
dc.titleAlteration by estrogen of the nucleoli in nerve cells of the rat hypothalamusen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, SK:skchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00226943en_HK
dc.identifier.pmid6201276-
dc.identifier.scopuseid_2-s2.0-0021309525en_HK
dc.identifier.volume235en_HK
dc.identifier.issue3en_HK
dc.identifier.spage485en_HK
dc.identifier.epage489en_HK
dc.identifier.isiWOS:A1984SH62600003-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridCohen, RS=35560739900en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK
dc.identifier.scopusauthoridPfaff, DW=36046651600en_HK

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