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Article: Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy

TitleGlutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy
Authors
KeywordsBreast cancer
Chemotherapy
Lutathione-S-transferase-pi
Prognosis and response predictions
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp
Citation
Cancer Investigation, 2010, v. 28 n. 5, p. 554-559 How to Cite?
AbstractGlutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies. Copyright © 2010 Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/146596
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorArun, BKen_HK
dc.contributor.authorGranville, LAen_HK
dc.contributor.authorYin, Gen_HK
dc.contributor.authorMiddleton, LPen_HK
dc.contributor.authorDawood, Sen_HK
dc.contributor.authorKau, SWen_HK
dc.contributor.authorKamal, Aen_HK
dc.contributor.authorHsu, Len_HK
dc.contributor.authorHortobagyi, GNen_HK
dc.contributor.authorSahin, AAen_HK
dc.date.accessioned2012-05-02T08:37:18Z-
dc.date.available2012-05-02T08:37:18Z-
dc.date.issued2010en_HK
dc.identifier.citationCancer Investigation, 2010, v. 28 n. 5, p. 554-559en_HK
dc.identifier.issn0735-7907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146596-
dc.description.abstractGlutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies. Copyright © 2010 Informa Healthcare USA, Inc.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.aspen_HK
dc.relation.ispartofCancer Investigationen_HK
dc.subjectBreast canceren_HK
dc.subjectChemotherapyen_HK
dc.subjectLutathione-S-transferase-pien_HK
dc.subjectPrognosis and response predictionsen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnthracyclines - Therapeutic Useen_US
dc.subject.meshAntineoplastic Agents - Therapeutic Useen_US
dc.subject.meshBreast Neoplasms - Drug Therapy - Enzymologyen_US
dc.subject.meshBridged Compounds - Therapeutic Useen_US
dc.subject.meshChemotherapy, Adjuvanten_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione S-Transferase Pi - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms, Hormone-Dependent - Drug Therapy - Enzymologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTaxoids - Therapeutic Useen_US
dc.titleGlutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapyen_HK
dc.typeArticleen_HK
dc.identifier.emailYin, G: gyin@hku.hken_HK
dc.identifier.authorityYin, G=rp00831en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/07357900903286925en_HK
dc.identifier.pmid20210524-
dc.identifier.scopuseid_2-s2.0-77952127407en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952127407&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue5en_HK
dc.identifier.spage554en_HK
dc.identifier.epage559en_HK
dc.identifier.isiWOS:000278739700015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridArun, BK=6603689664en_HK
dc.identifier.scopusauthoridGranville, LA=6701779041en_HK
dc.identifier.scopusauthoridYin, G=8725807500en_HK
dc.identifier.scopusauthoridMiddleton, LP=7005171424en_HK
dc.identifier.scopusauthoridDawood, S=16042124400en_HK
dc.identifier.scopusauthoridKau, SW=7005363979en_HK
dc.identifier.scopusauthoridKamal, A=15122143800en_HK
dc.identifier.scopusauthoridHsu, L=8280360600en_HK
dc.identifier.scopusauthoridHortobagyi, GN=7202399346en_HK
dc.identifier.scopusauthoridSahin, AA=7202605028en_HK

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