File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sequential continual reassessment method for two-dimensional dose finding.

TitleSequential continual reassessment method for two-dimensional dose finding.
Authors
Issue Date2008
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/
Citation
Statistics In Medicine, 2008, v. 27 n. 27, p. 5664-5678 How to Cite?
AbstractIt is common to encounter two-dimensional dose finding in phase I trials, for example, in trials combining multiple drugs, or in single-agent trials that simultaneously search for the maximum tolerated dose (MTD) and the optimal treatment schedule. In these cases, the traditional single-agent dose-finding methods are not directly applicable. We propose a simple and adaptive two-dimensional dose-finding design that can accommodate any type of single-agent dose-finding method. In particular, we convert the two-dimensional dose-finding trial to a series of one-dimensional dose-finding subtrials along shortened line search segments by fixing the dose level of one drug. We then conduct the subtrials sequentially. Based on the MTD obtained from the completed one-dimensional trial, we eliminate the doses that lie outside of the search range based on the partial order, and thereby efficiently shrink the two-dimensional dose-finding space. The proposed design dramatically reduces the sample size and still maintains good performance. We illustrate the design through extensive simulation studies motivated by clinical trials evaluating multiple drugs or dose and schedule combinations. Copyright (c) 2008 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/146591
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 1.811
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, Yen_HK
dc.contributor.authorYin, Gen_HK
dc.date.accessioned2012-05-02T08:37:15Z-
dc.date.available2012-05-02T08:37:15Z-
dc.date.issued2008en_HK
dc.identifier.citationStatistics In Medicine, 2008, v. 27 n. 27, p. 5664-5678en_HK
dc.identifier.issn0277-6715en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146591-
dc.description.abstractIt is common to encounter two-dimensional dose finding in phase I trials, for example, in trials combining multiple drugs, or in single-agent trials that simultaneously search for the maximum tolerated dose (MTD) and the optimal treatment schedule. In these cases, the traditional single-agent dose-finding methods are not directly applicable. We propose a simple and adaptive two-dimensional dose-finding design that can accommodate any type of single-agent dose-finding method. In particular, we convert the two-dimensional dose-finding trial to a series of one-dimensional dose-finding subtrials along shortened line search segments by fixing the dose level of one drug. We then conduct the subtrials sequentially. Based on the MTD obtained from the completed one-dimensional trial, we eliminate the doses that lie outside of the search range based on the partial order, and thereby efficiently shrink the two-dimensional dose-finding space. The proposed design dramatically reduces the sample size and still maintains good performance. We illustrate the design through extensive simulation studies motivated by clinical trials evaluating multiple drugs or dose and schedule combinations. Copyright (c) 2008 John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/en_HK
dc.relation.ispartofStatistics in medicineen_HK
dc.subject.meshClinical Trials, Phase I As Topicen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshDrug Toxicityen_US
dc.subject.meshHumansen_US
dc.subject.meshMaximum Tolerated Doseen_US
dc.subject.meshModels, Statisticalen_US
dc.subject.meshPharmaceutical Preparations - Administration & Dosageen_US
dc.subject.meshResearch Designen_US
dc.subject.meshSample Sizeen_US
dc.titleSequential continual reassessment method for two-dimensional dose finding.en_HK
dc.typeArticleen_HK
dc.identifier.emailYin, G: gyin@hku.hken_HK
dc.identifier.authorityYin, G=rp00831en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/sim.3372en_HK
dc.identifier.pmid18618901-
dc.identifier.scopuseid_2-s2.0-58749104211en_HK
dc.identifier.volume27en_HK
dc.identifier.issue27en_HK
dc.identifier.spage5664en_HK
dc.identifier.epage5678en_HK
dc.identifier.isiWOS:000260906000007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuan, Y=7402709174en_HK
dc.identifier.scopusauthoridYin, G=8725807500en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats