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- Publisher Website: 10.1002/sim.3372
- Scopus: eid_2-s2.0-58749104211
- PMID: 18618901
- WOS: WOS:000260906000007
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Article: Sequential continual reassessment method for two-dimensional dose finding.
Title | Sequential continual reassessment method for two-dimensional dose finding. |
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Authors | |
Keywords | Adaptive design Drug combination Phase I trial |
Issue Date | 2008 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/ |
Citation | Statistics In Medicine, 2008, v. 27 n. 27, p. 5664-5678 How to Cite? |
Abstract | It is common to encounter two-dimensional dose finding in phase I trials, for example, in trials combining multiple drugs, or in single-agent trials that simultaneously search for the maximum tolerated dose (MTD) and the optimal treatment schedule. In these cases, the traditional single-agent dose-finding methods are not directly applicable. We propose a simple and adaptive two-dimensional dose-finding design that can accommodate any type of single-agent dose-finding method. In particular, we convert the two-dimensional dose-finding trial to a series of one-dimensional dose-finding subtrials along shortened line search segments by fixing the dose level of one drug. We then conduct the subtrials sequentially. Based on the MTD obtained from the completed one-dimensional trial, we eliminate the doses that lie outside of the search range based on the partial order, and thereby efficiently shrink the two-dimensional dose-finding space. The proposed design dramatically reduces the sample size and still maintains good performance. We illustrate the design through extensive simulation studies motivated by clinical trials evaluating multiple drugs or dose and schedule combinations. Copyright (c) 2008 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/146591 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 1.348 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yuan, Y | en_HK |
dc.contributor.author | Yin, G | en_HK |
dc.date.accessioned | 2012-05-02T08:37:15Z | - |
dc.date.available | 2012-05-02T08:37:15Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Statistics In Medicine, 2008, v. 27 n. 27, p. 5664-5678 | en_HK |
dc.identifier.issn | 0277-6715 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/146591 | - |
dc.description.abstract | It is common to encounter two-dimensional dose finding in phase I trials, for example, in trials combining multiple drugs, or in single-agent trials that simultaneously search for the maximum tolerated dose (MTD) and the optimal treatment schedule. In these cases, the traditional single-agent dose-finding methods are not directly applicable. We propose a simple and adaptive two-dimensional dose-finding design that can accommodate any type of single-agent dose-finding method. In particular, we convert the two-dimensional dose-finding trial to a series of one-dimensional dose-finding subtrials along shortened line search segments by fixing the dose level of one drug. We then conduct the subtrials sequentially. Based on the MTD obtained from the completed one-dimensional trial, we eliminate the doses that lie outside of the search range based on the partial order, and thereby efficiently shrink the two-dimensional dose-finding space. The proposed design dramatically reduces the sample size and still maintains good performance. We illustrate the design through extensive simulation studies motivated by clinical trials evaluating multiple drugs or dose and schedule combinations. Copyright (c) 2008 John Wiley & Sons, Ltd. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/ | en_HK |
dc.relation.ispartof | Statistics in medicine | en_HK |
dc.subject | Adaptive design | - |
dc.subject | Drug combination | - |
dc.subject | Phase I trial | - |
dc.subject.mesh | Clinical Trials, Phase I As Topic | en_US |
dc.subject.mesh | Computer Simulation | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Drug Administration Schedule | en_US |
dc.subject.mesh | Drug Therapy, Combination | en_US |
dc.subject.mesh | Drug Toxicity | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Maximum Tolerated Dose | en_US |
dc.subject.mesh | Models, Statistical | en_US |
dc.subject.mesh | Pharmaceutical Preparations - Administration & Dosage | en_US |
dc.subject.mesh | Research Design | en_US |
dc.subject.mesh | Sample Size | en_US |
dc.title | Sequential continual reassessment method for two-dimensional dose finding. | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Yin, G: gyin@hku.hk | en_HK |
dc.identifier.authority | Yin, G=rp00831 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/sim.3372 | en_HK |
dc.identifier.pmid | 18618901 | - |
dc.identifier.scopus | eid_2-s2.0-58749104211 | en_HK |
dc.identifier.volume | 27 | en_HK |
dc.identifier.issue | 27 | en_HK |
dc.identifier.spage | 5664 | en_HK |
dc.identifier.epage | 5678 | en_HK |
dc.identifier.isi | WOS:000260906000007 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Yuan, Y=7402709174 | en_HK |
dc.identifier.scopusauthorid | Yin, G=8725807500 | en_HK |
dc.identifier.issnl | 0277-6715 | - |