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Article: Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

TitleCorrelation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer
Authors
KeywordsBreast
Chromosome aberrations
High-risk women
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
Modern Pathology, 2006, v. 19 n. 5, p. 622-629 How to Cite?
AbstractCytologic evaluation of ductal lavage or random periareolar fine-needle aspiration (FNA) specimens has been proposed to improve risk stratification of women at high risk for breast cancer. However, cytologic assessment of morphologic changes is subjective. To assess the utility of fluorescence in situ hybridization (FISH) in the categorization of breast lesions, we prospectively evaluated 32 random periareolar FNA specimens from 27 women at high risk for breast cancer. Cytologic specimens were prepared using the thin preparation technique, and diagnoses were made on the basis of previously published criteria. Specimens were also evaluated by FISH for chromosomes 1, 8, 11, and 17. Monosomy was defined as the loss of one signal or both signals in >20% of cells, and polysomy was defined as the presence of ≥3 signals in >6% of cells. Cytologic smears from seven invasive ductal carcinomas and nine benign breast specimens from women at low risk for breast cancer were included for comparison. In the high-risk group, cytologic findings were nonproliferative epithelium (NPE) in 16 cases and hyperplasia in 16 cases. Chromosomal aberrations were detected in 11 (69%) of 16 NPE cases, 14 (89%) of 16 hyperplasia cases, seven (100%) of seven carcinoma cases, and none of the low-risk cases. High-risk cases had significantly more monosomy of chromosomes 1, 11, and 17 and polysomy of chromosome 8 compared to low-risk cases and significantly less polysomy of chromosomes 1, 8, 11, and 17 compared to patients with cancer. There were no significant differences in monosomy or polysomy of individual chromosomes or a combination of chromosomes between the NPE and hyperplasia groups. This study shows that aberrations of chromosome number are common in high-risk women irrespective of cytologic findings. Studies evaluating the association between specific patterns of chromosomal polysomy and progression to malignancy may be warranted. © 2006 USCAP, Inc All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/146575
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSneige, Nen_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorYin, Gen_HK
dc.contributor.authorGong, Yen_HK
dc.contributor.authorArun, BKen_HK
dc.date.accessioned2012-05-02T08:37:07Z-
dc.date.available2012-05-02T08:37:07Z-
dc.date.issued2006en_HK
dc.identifier.citationModern Pathology, 2006, v. 19 n. 5, p. 622-629en_HK
dc.identifier.issn0893-3952en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146575-
dc.description.abstractCytologic evaluation of ductal lavage or random periareolar fine-needle aspiration (FNA) specimens has been proposed to improve risk stratification of women at high risk for breast cancer. However, cytologic assessment of morphologic changes is subjective. To assess the utility of fluorescence in situ hybridization (FISH) in the categorization of breast lesions, we prospectively evaluated 32 random periareolar FNA specimens from 27 women at high risk for breast cancer. Cytologic specimens were prepared using the thin preparation technique, and diagnoses were made on the basis of previously published criteria. Specimens were also evaluated by FISH for chromosomes 1, 8, 11, and 17. Monosomy was defined as the loss of one signal or both signals in >20% of cells, and polysomy was defined as the presence of ≥3 signals in >6% of cells. Cytologic smears from seven invasive ductal carcinomas and nine benign breast specimens from women at low risk for breast cancer were included for comparison. In the high-risk group, cytologic findings were nonproliferative epithelium (NPE) in 16 cases and hyperplasia in 16 cases. Chromosomal aberrations were detected in 11 (69%) of 16 NPE cases, 14 (89%) of 16 hyperplasia cases, seven (100%) of seven carcinoma cases, and none of the low-risk cases. High-risk cases had significantly more monosomy of chromosomes 1, 11, and 17 and polysomy of chromosome 8 compared to low-risk cases and significantly less polysomy of chromosomes 1, 8, 11, and 17 compared to patients with cancer. There were no significant differences in monosomy or polysomy of individual chromosomes or a combination of chromosomes between the NPE and hyperplasia groups. This study shows that aberrations of chromosome number are common in high-risk women irrespective of cytologic findings. Studies evaluating the association between specific patterns of chromosomal polysomy and progression to malignancy may be warranted. © 2006 USCAP, Inc All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/en_HK
dc.relation.ispartofModern Pathologyen_HK
dc.subjectBreasten_HK
dc.subjectChromosome aberrationsen_HK
dc.subjectHigh-risk womenen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiopsy, Fine-Needleen_US
dc.subject.meshBreast - Metabolism - Pathologyen_US
dc.subject.meshBreast Neoplasms - Genetics - Pathologyen_US
dc.subject.meshChromosomal Instabilityen_US
dc.subject.meshChromosomes, Human, Pair 1 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 11 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 17 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 8 - Geneticsen_US
dc.subject.meshCytodiagnosis - Methodsen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperplasiaen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Factorsen_US
dc.titleCorrelation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast canceren_HK
dc.typeArticleen_HK
dc.identifier.emailYin, G: gyin@hku.hken_HK
dc.identifier.authorityYin, G=rp00831en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/modpathol.3800571en_HK
dc.identifier.pmid16528376-
dc.identifier.scopuseid_2-s2.0-33646122223en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646122223&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue5en_HK
dc.identifier.spage622en_HK
dc.identifier.epage629en_HK
dc.identifier.isiWOS:000237057600002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSneige, N=7007099187en_HK
dc.identifier.scopusauthoridLiu, B=7408690803en_HK
dc.identifier.scopusauthoridYin, G=8725807500en_HK
dc.identifier.scopusauthoridGong, Y=8610494600en_HK
dc.identifier.scopusauthoridArun, BK=6603689664en_HK
dc.identifier.citeulike546928-

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