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Article: Breaking up prolonged sitting reduces postprandial glucose and insulin responses

TitleBreaking up prolonged sitting reduces postprandial glucose and insulin responses
Authors
Issue Date2012
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2012, v. 35 n. 5, p. 976-983 How to Cite?
AbstractOBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95%CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) · h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) · h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk. © 2012 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/146438
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDunstan, DWen_HK
dc.contributor.authorKingwell, BAen_HK
dc.contributor.authorLarsen, Ren_HK
dc.contributor.authorHealy, GNen_HK
dc.contributor.authorCerin, Een_HK
dc.contributor.authorHamilton, MTen_HK
dc.contributor.authorShaw, JEen_HK
dc.contributor.authorBertovic, DAen_HK
dc.contributor.authorZimmet, PZen_HK
dc.contributor.authorSalmon, Jen_HK
dc.contributor.authorOwen, Nen_HK
dc.date.accessioned2012-04-24T07:54:01Z-
dc.date.available2012-04-24T07:54:01Z-
dc.date.issued2012en_HK
dc.identifier.citationDiabetes Care, 2012, v. 35 n. 5, p. 976-983en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146438-
dc.description.abstractOBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95%CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) · h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) · h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk. © 2012 by the American Diabetes Association.en_HK
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.titleBreaking up prolonged sitting reduces postprandial glucose and insulin responsesen_HK
dc.typeArticleen_HK
dc.identifier.emailCerin, E: ecerin@hku.hken_HK
dc.identifier.authorityCerin, E=rp00890en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2337/dc11-1931en_HK
dc.identifier.pmid22374636-
dc.identifier.pmcidPMC3329818-
dc.identifier.scopuseid_2-s2.0-84862096118en_HK
dc.identifier.hkuros199221en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862096118&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue5en_HK
dc.identifier.spage976en_HK
dc.identifier.epage983en_HK
dc.identifier.isiWOS:000303218900009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDunstan, DW=7102907266en_HK
dc.identifier.scopusauthoridKingwell, BA=7005360682en_HK
dc.identifier.scopusauthoridLarsen, R=36774577900en_HK
dc.identifier.scopusauthoridHealy, GN=8093628700en_HK
dc.identifier.scopusauthoridCerin, E=14522064200en_HK
dc.identifier.scopusauthoridHamilton, MT=55170330500en_HK
dc.identifier.scopusauthoridShaw, JE=55233462200en_HK
dc.identifier.scopusauthoridBertovic, DA=6506803772en_HK
dc.identifier.scopusauthoridZimmet, PZ=7102179242en_HK
dc.identifier.scopusauthoridSalmon, J=7201427314en_HK
dc.identifier.scopusauthoridOwen, N=7102307209en_HK
dc.identifier.citeulike10427916-

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