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Article: G-quadruplex DNA aptamers and their ligands: Structure, function and application

TitleG-quadruplex DNA aptamers and their ligands: Structure, function and application
Authors
KeywordsAptamer
G-quadruplex
G-quartet
G4 tetrad
Sclerostin
SELEX
Thrombin
Issue Date2012
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htm
Citation
Current Pharmaceutical Design, 2012, v. 18 n. 14, p. 2014-2026 How to Cite?
AbstractHighly specific and tight-binding nucleic acid aptamers have been selected against a variety of molecular targets for over 20 years. A significant proportion of these oligonucleotides display G-quadruplex structures, particularly for DNA aptamers, that enable molecular recognition of their ligands. G-quadruplex structures couple a common scaffold to varying loop motifs that act in target recognition. Here, we review DNA G-quadruplex aptamers and their ligands from a structural and functional perspective. We compare the diversity of DNA G-quadruplex aptamers selected against multiple ligand targets, and consider structure with a particular focus on dissecting the thrombin binding aptamer - thrombin interaction. Therapeutic and analytical applications of DNA G-quadruplex aptamers are also discussed. Understanding DNA G-quadruplex aptamers carries implications not only for therapeutics and diagnostics, but also in the natural biochemistry of guanine-rich nucleic acids. © 2012 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/146385
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.220
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTucker, WOen_HK
dc.contributor.authorShum, KTen_HK
dc.contributor.authorTanner, JAen_HK
dc.date.accessioned2012-04-24T07:50:24Z-
dc.date.available2012-04-24T07:50:24Z-
dc.date.issued2012en_HK
dc.identifier.citationCurrent Pharmaceutical Design, 2012, v. 18 n. 14, p. 2014-2026en_HK
dc.identifier.issn1381-6128en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146385-
dc.description.abstractHighly specific and tight-binding nucleic acid aptamers have been selected against a variety of molecular targets for over 20 years. A significant proportion of these oligonucleotides display G-quadruplex structures, particularly for DNA aptamers, that enable molecular recognition of their ligands. G-quadruplex structures couple a common scaffold to varying loop motifs that act in target recognition. Here, we review DNA G-quadruplex aptamers and their ligands from a structural and functional perspective. We compare the diversity of DNA G-quadruplex aptamers selected against multiple ligand targets, and consider structure with a particular focus on dissecting the thrombin binding aptamer - thrombin interaction. Therapeutic and analytical applications of DNA G-quadruplex aptamers are also discussed. Understanding DNA G-quadruplex aptamers carries implications not only for therapeutics and diagnostics, but also in the natural biochemistry of guanine-rich nucleic acids. © 2012 Bentham Science Publishers.en_HK
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cpd/index.htmen_HK
dc.relation.ispartofCurrent Pharmaceutical Designen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAptameren_HK
dc.subjectG-quadruplexen_HK
dc.subjectG-quarteten_HK
dc.subjectG4 tetraden_HK
dc.subjectSclerostinen_HK
dc.subjectSELEXen_HK
dc.subjectThrombinen_HK
dc.titleG-quadruplex DNA aptamers and their ligands: Structure, function and applicationen_HK
dc.typeArticleen_HK
dc.identifier.emailTanner, JA:jatanner@hku.hken_HK
dc.identifier.authorityTanner, JA=rp00495en_HK
dc.description.naturepostprint-
dc.identifier.doi10.2174/138161212799958477en_HK
dc.identifier.pmid22376117-
dc.identifier.scopuseid_2-s2.0-84860122883en_HK
dc.identifier.hkuros199328en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860122883&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue14en_HK
dc.identifier.spage2014en_HK
dc.identifier.epage2026en_HK
dc.identifier.isiWOS:000304823300013-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridTucker, WO=55195360400en_HK
dc.identifier.scopusauthoridShum, KT=20436474600en_HK
dc.identifier.scopusauthoridTanner, JA=35513993000en_HK

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