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Article: Prediction of the secondary structure and B cell epitopes of human metapneumovirus attachment protein

TitlePrediction of the secondary structure and B cell epitopes of human metapneumovirus attachment protein
Authors
KeywordsB cell epitope
G protein
Human metapneumovirus
Secondary structure
Issue Date2005
Citation
Chinese Journal Of Microbiology And Immunology, 2005, v. 25 n. 12, p. 1031-1034 How to Cite?
AbstractObjective: To predict the secondary structure and B cell epitopes of human metapneumovirus attachment (G) protein. Methods: The secondary structure and transmembrane domain were predicted by SOPMA and HMMTOP respectively. Hydrophilicity profile, surface probability and antigenicity index predicted by methods of Kyte-Doolittle, Emini and Jameson-Wolf were combined and the possible B cell epitopes of G protein were predicted. Results: The flexible regions were the main structure type, locating at the N-terminal No.27-31, 38-39, 56-77, 81-124, 131-146, 151-167, 180-188, 193-212 regions. There were α-helix regions at the N-terminal No. 5-26, 40-46, 125-130, 168-175, 213-218. And the N-terminal No. 1-4, 32-37, 47-55, 78-80, 147-150, 176-179, 189-192 were the β-sheet regions. The N-terminal No.32-51 was the transmembrane domain. B cell epitopes were probably located at or adjacent the N-terminal No.55-77, 80-104, 111-126, 130-167, 178-210 regions, and the former three fragments were the predominant epitopes. Conclusion: Prediction of the secondary structure and B cell epitopes of G protein lay the basis for studies of the characteristics of the protein, development of epitope-based vaccine and the monoclonal antibody against G protein.
Persistent Identifierhttp://hdl.handle.net/10722/146345
ISSN
2015 SCImago Journal Rankings: 0.108
References

 

DC FieldValueLanguage
dc.contributor.authorMao, HWen_HK
dc.contributor.authorZhao, XDen_HK
dc.contributor.authorYang, XQen_HK
dc.date.accessioned2012-04-20T02:05:11Z-
dc.date.available2012-04-20T02:05:11Z-
dc.date.issued2005en_HK
dc.identifier.citationChinese Journal Of Microbiology And Immunology, 2005, v. 25 n. 12, p. 1031-1034en_HK
dc.identifier.issn0254-5101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146345-
dc.description.abstractObjective: To predict the secondary structure and B cell epitopes of human metapneumovirus attachment (G) protein. Methods: The secondary structure and transmembrane domain were predicted by SOPMA and HMMTOP respectively. Hydrophilicity profile, surface probability and antigenicity index predicted by methods of Kyte-Doolittle, Emini and Jameson-Wolf were combined and the possible B cell epitopes of G protein were predicted. Results: The flexible regions were the main structure type, locating at the N-terminal No.27-31, 38-39, 56-77, 81-124, 131-146, 151-167, 180-188, 193-212 regions. There were α-helix regions at the N-terminal No. 5-26, 40-46, 125-130, 168-175, 213-218. And the N-terminal No. 1-4, 32-37, 47-55, 78-80, 147-150, 176-179, 189-192 were the β-sheet regions. The N-terminal No.32-51 was the transmembrane domain. B cell epitopes were probably located at or adjacent the N-terminal No.55-77, 80-104, 111-126, 130-167, 178-210 regions, and the former three fragments were the predominant epitopes. Conclusion: Prediction of the secondary structure and B cell epitopes of G protein lay the basis for studies of the characteristics of the protein, development of epitope-based vaccine and the monoclonal antibody against G protein.en_HK
dc.languageengen_US
dc.relation.ispartofChinese Journal of Microbiology and Immunologyen_HK
dc.subjectB cell epitopeen_HK
dc.subjectG proteinen_HK
dc.subjectHuman metapneumovirusen_HK
dc.subjectSecondary structureen_HK
dc.titlePrediction of the secondary structure and B cell epitopes of human metapneumovirus attachment proteinen_HK
dc.typeArticleen_HK
dc.identifier.emailMao, HW:hwmau@hku.hken_HK
dc.identifier.authorityMao, HW=rp01595en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33644926996en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644926996&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1031en_HK
dc.identifier.epage1034en_HK
dc.identifier.scopusauthoridMao, HW=25632489000en_HK
dc.identifier.scopusauthoridZhao, XD=7407577513en_HK
dc.identifier.scopusauthoridYang, XQ=13606095400en_HK

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