File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Emulsification of silicone oil and eye movements

TitleEmulsification of silicone oil and eye movements
Authors
Issue Date2011
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2011, v. 52 n. 13, p. 9721-9727 How to Cite?
AbstractPurpose. Emulsification is an inherent problem of silicone oil used in vitreoretinal surgery. It has been shown that silicone oil can be made more resistant to emulsification and easier to inject by adding high-molecular-weight components (5% or 10% 423-kDa polydimethylsiloxane [PDMS]) to normal 1000 mPa · s silicone oil. The authors hypothesize that this might also reduce the movement of oil within an eye. Methods. A model eye chamber made of surface-modified poly(methyl methacrylate) was driven by a computer and a stepper motor to mimic saccadic eye movement. Seven silicone oils with different shear and extensional viscosities were tested. Two sets of eye movements were used: (amplitude 9°, angular velocity 390°/s, duration 50 ms) and (amplitude 90°, angular velocity 360°/s, duration 300 ms). The movements were captured and analyzed by video recording. Results. The angular velocity of an oil bubble relative to the eye chamber appears to form an exponential relationship with its shear viscosity. Depending on the thickness of the film of aqueous between the eye wall and the oil bubble, the shear rate was estimated to be between 6 and 14 × 104 s -1. The addition of 10% of 423-kDa PDMS to 1000 mPa · s silicone oil significantly reduced the peak relative velocity compared with the base oil of 1000 mPa · s but not 5000 mPa · s. Conclusions. The addition of high molecular components to a base oil increases its extensional and shear viscosity. Although the extensional viscosity affected the ease with which the oil could be injected, the results showed that it was the shear viscosity that determined the relative velocity between the oil and the wall of the vitreous cavity, and thus the propensity to emulsify. © 2011 The Association for Research in Vision and Ophthalmology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/146323
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
K. B. Woo Foundation
Funding Information:

Supported by the University Development Fund of the University of Hong Kong and the K. B. Woo Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, YKen_HK
dc.contributor.authorNg, COen_HK
dc.contributor.authorKnox, PCen_HK
dc.contributor.authorGarvey, MJen_HK
dc.contributor.authorWilliams, RLen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:50:13Z-
dc.date.available2012-04-10T01:50:13Z-
dc.date.issued2011en_HK
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2011, v. 52 n. 13, p. 9721-9727en_HK
dc.identifier.issn0146-0404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146323-
dc.description.abstractPurpose. Emulsification is an inherent problem of silicone oil used in vitreoretinal surgery. It has been shown that silicone oil can be made more resistant to emulsification and easier to inject by adding high-molecular-weight components (5% or 10% 423-kDa polydimethylsiloxane [PDMS]) to normal 1000 mPa · s silicone oil. The authors hypothesize that this might also reduce the movement of oil within an eye. Methods. A model eye chamber made of surface-modified poly(methyl methacrylate) was driven by a computer and a stepper motor to mimic saccadic eye movement. Seven silicone oils with different shear and extensional viscosities were tested. Two sets of eye movements were used: (amplitude 9°, angular velocity 390°/s, duration 50 ms) and (amplitude 90°, angular velocity 360°/s, duration 300 ms). The movements were captured and analyzed by video recording. Results. The angular velocity of an oil bubble relative to the eye chamber appears to form an exponential relationship with its shear viscosity. Depending on the thickness of the film of aqueous between the eye wall and the oil bubble, the shear rate was estimated to be between 6 and 14 × 104 s -1. The addition of 10% of 423-kDa PDMS to 1000 mPa · s silicone oil significantly reduced the peak relative velocity compared with the base oil of 1000 mPa · s but not 5000 mPa · s. Conclusions. The addition of high molecular components to a base oil increases its extensional and shear viscosity. Although the extensional viscosity affected the ease with which the oil could be injected, the results showed that it was the shear viscosity that determined the relative velocity between the oil and the wall of the vitreous cavity, and thus the propensity to emulsify. © 2011 The Association for Research in Vision and Ophthalmology, Inc.en_HK
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_HK
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_HK
dc.subject.meshDimethylpolysiloxanes - Chemistryen_US
dc.subject.meshEmulsionsen_US
dc.subject.meshEndotamponadeen_US
dc.subject.meshModels, Anatomicen_US
dc.subject.meshSaccades - Physiologyen_US
dc.subject.meshSilicone Oils - Chemistryen_US
dc.subject.meshViscosityen_US
dc.subject.meshVitreoretinal Surgeryen_US
dc.titleEmulsification of silicone oil and eye movementsen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, CO: cong@hku.hken_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityNg, CO=rp00224en_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.11-8586en_HK
dc.identifier.pmid22110069en_HK
dc.identifier.scopuseid_2-s2.0-84863799458en_HK
dc.identifier.hkuros198411-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863799458&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue13en_HK
dc.identifier.spage9721en_HK
dc.identifier.epage9727en_HK
dc.identifier.eissn1552-5783-
dc.identifier.isiWOS:000298628200064-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, YK=55312712500en_HK
dc.identifier.scopusauthoridNg, CO=7401705594en_HK
dc.identifier.scopusauthoridKnox, PC=7006264933en_HK
dc.identifier.scopusauthoridGarvey, MJ=7102440425en_HK
dc.identifier.scopusauthoridWilliams, RL=10042153900en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats