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Article: Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma

TitleProgenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma
Authors
Issue Date2011
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
Journal of Biomedicine and Biotechnology, 2011, v. 2011, article no. 412743 How to Cite?
AbstractSeveral adult stem cell types have been found in different parts of the eye, including the corneal epithelium, conjunctiva, and retina. In addition to these, there have been accumulating evidence that some stem-like cells reside in the transition area between the peripheral corneal endothelium (CE) and the anterior nonfiltering portion of the trabecular meshwork (TM), which is known as the Schwalbe's Ring region. These stem/progenitor cells may supply new cells for the CE and TM. In fact, the CE and TM share certain similarities in terms of their embryonic origin and proliferative capacity in vivo. In this paper, we discuss the putative stem cell source which has the potential for replacement of lost and nonfunctional cells in CE diseases and glaucoma. The future development of personalized stem cell therapies for the CE and TM may reduce the requirement of corneal grafts and surgical treatments in glaucoma.
Persistent Identifierhttp://hdl.handle.net/10722/146319
ISSN
2014 Impact Factor: 3.169
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, WYen_HK
dc.contributor.authorSheridan, Cen_HK
dc.contributor.authorGrierson, Ien_HK
dc.contributor.authorMason, Sen_HK
dc.contributor.authorKearns, Ven_HK
dc.contributor.authorLo, ACYen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:50:12Z-
dc.date.available2012-04-10T01:50:12Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal of Biomedicine and Biotechnology, 2011, v. 2011, article no. 412743en_HK
dc.identifier.issn1110-7243en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146319-
dc.description.abstractSeveral adult stem cell types have been found in different parts of the eye, including the corneal epithelium, conjunctiva, and retina. In addition to these, there have been accumulating evidence that some stem-like cells reside in the transition area between the peripheral corneal endothelium (CE) and the anterior nonfiltering portion of the trabecular meshwork (TM), which is known as the Schwalbe's Ring region. These stem/progenitor cells may supply new cells for the CE and TM. In fact, the CE and TM share certain similarities in terms of their embryonic origin and proliferative capacity in vivo. In this paper, we discuss the putative stem cell source which has the potential for replacement of lost and nonfunctional cells in CE diseases and glaucoma. The future development of personalized stem cell therapies for the CE and TM may reduce the requirement of corneal grafts and surgical treatments in glaucoma.en_HK
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.htmlen_HK
dc.relation.ispartofJournal of Biomedicine and Biotechnologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCattle-
dc.subject.meshCell Differentiation - physiology-
dc.subject.meshEndothelium, Corneal - chemistry - cytology - metabolism-
dc.subject.meshStem Cells - cytology-
dc.subject.meshTrabecular Meshwork - chemistry - cytology - metabolism-
dc.titleProgenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucomaen_HK
dc.typeArticleen_HK
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityLo, ACY=rp00425en_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1155/2011/412743en_HK
dc.identifier.pmid22187525-
dc.identifier.pmcidPMC3236530-
dc.identifier.scopuseid_2-s2.0-84855556819en_HK
dc.identifier.hkuros212095-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855556819&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2011, article no. 412743en_HK
dc.identifier.isiWOS:000298692800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridLo, ACY=7102780640en_HK
dc.identifier.scopusauthoridKearns, V=28267783100en_HK
dc.identifier.scopusauthoridMason, S=8706512600en_HK
dc.identifier.scopusauthoridGrierson, I=7005212606en_HK
dc.identifier.scopusauthoridSheridan, C=7004974390en_HK
dc.identifier.scopusauthoridYu, WY=37662743600en_HK

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