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Conference Paper: Apoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue

TitleApoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue
Authors
KeywordsCaspase
Mitochondria
Necrosis
Neuroprotection
Programmed cell death
Issue Date2011
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OPH
Citation
Ophthalmologica, 2011, v. 226 SUPPL. 1, p. 10-17 How to Cite?
AbstractRetinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition. © 2011 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/146315
ISSN
2014 Impact Factor: 1.676
2014 SCImago Journal Rankings: 0.922
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, ACYen_HK
dc.contributor.authorWoo, TTYen_HK
dc.contributor.authorWong, RLMen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:50:10Z-
dc.date.available2012-04-10T01:50:10Z-
dc.date.issued2011en_HK
dc.identifier.citationOphthalmologica, 2011, v. 226 SUPPL. 1, p. 10-17en_HK
dc.identifier.issn0030-3755en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146315-
dc.description.abstractRetinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition. © 2011 S. Karger AG, Basel.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OPHen_HK
dc.relation.ispartofOphthalmologicaen_HK
dc.rightsOphthalmologica. Copyright © S Karger AG.-
dc.subjectCaspaseen_HK
dc.subjectMitochondriaen_HK
dc.subjectNecrosisen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectProgrammed cell deathen_HK
dc.subject.meshApoptosisen_US
dc.subject.meshCytoprotection - physiologyen_US
dc.subject.meshNecrosisen_US
dc.subject.meshPhotoreceptor Cells, Vertebrate - pathologyen_US
dc.subject.meshRetinal Detachment - pathologyen_US
dc.titleApoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescueen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.emailWong, RLM: ray81@hku.hken_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityLo, ACY=rp00425en_HK
dc.identifier.authorityWong, RLM=rp01394en_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000328206en_HK
dc.identifier.pmid21778775en_HK
dc.identifier.scopuseid_2-s2.0-79960706234en_HK
dc.identifier.hkuros197809-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960706234&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume226en_HK
dc.identifier.issueSUPPL. 1en_HK
dc.identifier.spage10en_HK
dc.identifier.epage17en_HK
dc.identifier.isiWOS:000293257900003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLo, ACY=7102780640en_HK
dc.identifier.scopusauthoridWoo, TTY=53265281800en_HK
dc.identifier.scopusauthoridWong, RLM=36244688100en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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