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Conference Paper: Apoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue
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TitleApoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue
 
AuthorsLo, ACY1
Woo, TTY1
Wong, RLM1
Wong, D1
 
KeywordsCaspase
Mitochondria
Necrosis
Neuroprotection
Programmed cell death
 
Issue Date2011
 
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OPH
 
CitationOphthalmologica, 2011, v. 226 SUPPL. 1, p. 10-17 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000328206
 
AbstractRetinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition. © 2011 S. Karger AG, Basel.
 
ISSN0030-3755
2013 Impact Factor: 1.867
 
DOIhttp://dx.doi.org/10.1159/000328206
 
ISI Accession Number IDWOS:000293257900003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLo, ACY
 
dc.contributor.authorWoo, TTY
 
dc.contributor.authorWong, RLM
 
dc.contributor.authorWong, D
 
dc.date.accessioned2012-04-10T01:50:10Z
 
dc.date.available2012-04-10T01:50:10Z
 
dc.date.issued2011
 
dc.description.abstractRetinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition. © 2011 S. Karger AG, Basel.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationOphthalmologica, 2011, v. 226 SUPPL. 1, p. 10-17 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000328206
 
dc.identifier.doihttp://dx.doi.org/10.1159/000328206
 
dc.identifier.epage17
 
dc.identifier.hkuros197809
 
dc.identifier.isiWOS:000293257900003
 
dc.identifier.issn0030-3755
2013 Impact Factor: 1.867
 
dc.identifier.issueSUPPL. 1
 
dc.identifier.pmid21778775
 
dc.identifier.scopuseid_2-s2.0-79960706234
 
dc.identifier.spage10
 
dc.identifier.urihttp://hdl.handle.net/10722/146315
 
dc.identifier.volume226
 
dc.languageeng
 
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OPH
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofOphthalmologica
 
dc.relation.referencesReferences in Scopus
 
dc.rightsOphthalmologica. Copyright © S Karger AG.
 
dc.subject.meshApoptosis
 
dc.subject.meshCytoprotection - physiology
 
dc.subject.meshNecrosis
 
dc.subject.meshPhotoreceptor Cells, Vertebrate - pathology
 
dc.subject.meshRetinal Detachment - pathology
 
dc.subjectCaspase
 
dc.subjectMitochondria
 
dc.subjectNecrosis
 
dc.subjectNeuroprotection
 
dc.subjectProgrammed cell death
 
dc.titleApoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue
 
dc.typeConference_Paper
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine