Conference Paper: Apoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue

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TitleApoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue
AuthorsLo, ACY1
Woo, TTY1
Wong, RLM1
Wong, D1
KeywordsCaspase
Mitochondria
Necrosis
Neuroprotection
Programmed cell death
Issue Date2011
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OPH
CitationOphthalmologica, 2011, v. 226 SUPPL. 1, p. 10-17 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000328206
AbstractRetinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition. © 2011 S. Karger AG, Basel.
ISSN0030-3755
2011 Impact Factor: 1.424
2011 SCImago Journal Rankings: 0.095
DOIhttp://dx.doi.org/10.1159/000328206
ISI Accession Number IDWOS:000293257900003
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLo, ACY
dc.contributor.authorWoo, TTY
dc.contributor.authorWong, RLM
dc.contributor.authorWong, D
dc.date.accessioned2012-04-10T01:50:10Z
dc.date.available2012-04-10T01:50:10Z
dc.date.issued2011
dc.description.abstractRetinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition. © 2011 S. Karger AG, Basel.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationOphthalmologica, 2011, v. 226 SUPPL. 1, p. 10-17 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000328206
dc.identifier.doihttp://dx.doi.org/10.1159/000328206
dc.identifier.epage17
dc.identifier.hkuros197809
dc.identifier.isiWOS:000293257900003
dc.identifier.issn0030-3755
2011 Impact Factor: 1.424
2011 SCImago Journal Rankings: 0.095
dc.identifier.issueSUPPL. 1
dc.identifier.pmid21778775
dc.identifier.scopuseid_2-s2.0-79960706234
dc.identifier.spage10
dc.identifier.urihttp://hdl.handle.net/10722/146315
dc.identifier.volume226
dc.languageeng
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OPH
dc.publisher.placeSwitzerland
dc.relation.ispartofOphthalmologica
dc.relation.referencesReferences in Scopus
dc.rightsOphthalmologica. Copyright © S Karger AG.
dc.subject.meshApoptosis
dc.subject.meshCytoprotection - physiology
dc.subject.meshNecrosis
dc.subject.meshPhotoreceptor Cells, Vertebrate - pathology
dc.subject.meshRetinal Detachment - pathology
dc.subjectCaspase
dc.subjectMitochondria
dc.subjectNecrosis
dc.subjectNeuroprotection
dc.subjectProgrammed cell death
dc.titleApoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue
dc.typeConference_Paper
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine