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Article: Surgical management of subfoveal choroidal neovascular membranes in age-related macular degeneration by macular relocation: Experiences of an early-stopped randomised clinical trial (MARAN Study)

TitleSurgical management of subfoveal choroidal neovascular membranes in age-related macular degeneration by macular relocation: Experiences of an early-stopped randomised clinical trial (MARAN Study)
Authors
KeywordsAge-related macular degeneration
Macular relocation
Randomised clinical trial
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eye
Citation
Eye, 2010, v. 24 n. 2, p. 284-289 How to Cite?
AbstractRationale The MARAN (Macular Relocation in Age-related Neovascular disease) trial was planned to assess the effectiveness of full macular relocation (MR) in patients with neovascular age-related macular degeneration (AMD). Design Randomised, prospective, controlled clinical trial. Methods Patients suffering from visual loss because of AMD were randomised to either surgery or a control group receiving standard treatment (observation or photodynamic therapy (PDT)). The primary end point was the change of visual acuity (VA) (ETDRS) 52 weeks after randomisation compared with initial VA, and secondary end points included reading performance, contrast sensitivity, stability of fixation, eye-specific quality of life, and the absolute number of letters read correctly at 52 weeks compared with initial examination. Results Owing to early determination, only 28 patients were included in the study. The study did not show a difference between the two groups with respect to the final visual result or any of the secondary outcomes measured. The study was limited by the low recruitment that was, at least in part, attributed to the inherent risks for those patients randomised to the surgical arm of the study as well as to the emerging new treatments for AMD. Conclusion The results of the MARAN trial failed to recruit a sufficient number of patients and a superiority of surgery over observation or PDT in patients with exudative AMD was not shown. There was a trend that the reading function was superior after surgery. In the light of the new pharmacological treatments, surgical options such as MR will be an option for only selected cases. © 2010 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/146310
ISSN
2015 Impact Factor: 2.213
2015 SCImago Journal Rankings: 1.132
ISI Accession Number ID
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft
Brunnenbusch Stein Stiftung
Glaser Stiftung
RetinoVit Stiftung Koln
Funding Information:

This study was funded by the Deutsche Forschungsgemeinschaft, the Brunnenbusch Stein Stiftung, the Glaser Stiftung and the RetinoVit Stiftung Koln. Joussen AM, Wong D, Walter P, Kirchhof B were involved in the study design and writing of the paper. Dreyhaupt J, Bauer C, Munzinger J, Unnebrink K, Freiberger A, Seibert-Grafe M, and Victor N were involved in the statistical evaluation, monitoring and writing of the paper.

References

 

DC FieldValueLanguage
dc.contributor.authorJoussen, AMen_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorWalter, Pen_HK
dc.contributor.authorKirchhof, Ben_HK
dc.contributor.authorDreyhaupt, Jen_HK
dc.contributor.authorBauer, Cen_HK
dc.contributor.authorMunzinger, Jen_HK
dc.contributor.authorUnnebrink, Ken_HK
dc.contributor.authorFreiberger, Aen_HK
dc.contributor.authorSeibertGrafe, Men_HK
dc.contributor.authorVictor, Nen_HK
dc.date.accessioned2012-04-10T01:50:08Z-
dc.date.available2012-04-10T01:50:08Z-
dc.date.issued2010en_HK
dc.identifier.citationEye, 2010, v. 24 n. 2, p. 284-289en_HK
dc.identifier.issn0950-222Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146310-
dc.description.abstractRationale The MARAN (Macular Relocation in Age-related Neovascular disease) trial was planned to assess the effectiveness of full macular relocation (MR) in patients with neovascular age-related macular degeneration (AMD). Design Randomised, prospective, controlled clinical trial. Methods Patients suffering from visual loss because of AMD were randomised to either surgery or a control group receiving standard treatment (observation or photodynamic therapy (PDT)). The primary end point was the change of visual acuity (VA) (ETDRS) 52 weeks after randomisation compared with initial VA, and secondary end points included reading performance, contrast sensitivity, stability of fixation, eye-specific quality of life, and the absolute number of letters read correctly at 52 weeks compared with initial examination. Results Owing to early determination, only 28 patients were included in the study. The study did not show a difference between the two groups with respect to the final visual result or any of the secondary outcomes measured. The study was limited by the low recruitment that was, at least in part, attributed to the inherent risks for those patients randomised to the surgical arm of the study as well as to the emerging new treatments for AMD. Conclusion The results of the MARAN trial failed to recruit a sufficient number of patients and a superiority of surgery over observation or PDT in patients with exudative AMD was not shown. There was a trend that the reading function was superior after surgery. In the light of the new pharmacological treatments, surgical options such as MR will be an option for only selected cases. © 2010 Macmillan Publishers Limited All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eyeen_HK
dc.relation.ispartofEyeen_HK
dc.subjectAge-related macular degenerationen_HK
dc.subjectMacular relocationen_HK
dc.subjectRandomised clinical trialen_HK
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChoroidal Neovascularization - Etiology - Physiopathology - Surgeryen_US
dc.subject.meshContrast Sensitivity - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFixation, Ocular - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMacular Degeneration - Complications - Physiopathology - Surgeryen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshQuality Of Lifeen_US
dc.subject.meshReadingen_US
dc.subject.meshTask Performance And Analysisen_US
dc.subject.meshVisual Acuityen_US
dc.titleSurgical management of subfoveal choroidal neovascular membranes in age-related macular degeneration by macular relocation: Experiences of an early-stopped randomised clinical trial (MARAN Study)en_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/eye.2009.107en_HK
dc.identifier.pmid19478822-
dc.identifier.scopuseid_2-s2.0-77049094199en_HK
dc.identifier.hkuros164193-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77049094199&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue2en_HK
dc.identifier.spage284en_HK
dc.identifier.epage289en_HK
dc.identifier.isiWOS:000274397900012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridJoussen, AM=35080476300en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridWalter, P=7202818204en_HK
dc.identifier.scopusauthoridKirchhof, B=7006285825en_HK
dc.identifier.scopusauthoridDreyhaupt, J=6506263582en_HK
dc.identifier.scopusauthoridBauer, C=37092408700en_HK
dc.identifier.scopusauthoridMunzinger, J=35334875200en_HK
dc.identifier.scopusauthoridUnnebrink, K=6701362622en_HK
dc.identifier.scopusauthoridFreiberger, A=14218878900en_HK
dc.identifier.scopusauthoridSeibertGrafe, M=12785660300en_HK
dc.identifier.scopusauthoridVictor, N=7003512865en_HK
dc.identifier.citeulike4692229-

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