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Article: Case selection in macular relocation surgery for age related macular degeneration

TitleCase selection in macular relocation surgery for age related macular degeneration
Authors
Issue Date2004
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2004, v. 88 n. 2, p. 186-190 How to Cite?
AbstractBackground: To date there has been no randomised controlled trial demonstrating the safety and efficacy of macular relocation surgery (MRS) for age related macular degeneration (AMD). Vision can be improved in some patients and made worse in others despite successful surgery or because of complications. Purpose: To determine which patients would benefit from MRS. Methods: Twenty nine patients with exudative AMD took part in a prospective, non-comparative, interventional study. Macular relocation surgery involved phacoemulsification, vitrectomy, 360° retinotomy, excision of choroidal neovascular membrane, and macular relocation using an infusion of 5-fluorouracil and low molecular weight heparin as adjuvant to prevent proliferative vitreoretinopathy. Patients underwent protocol refraction preoperotively and six-monthly postoperatively by designated optometrists. Preoperotive fundus fluorescein angiograms were read by masked observers and the lesions were classified according to a set protocol. The main outcome measures were visual improvement, final vision of better than 20/400, reading speed, critical print size. Logistic and multiple stepwise linear regressions were used to identify independent factors which predicted the main outcomes. Results: Preoperative visual acuity (20/120 or worse) and lesion type (predominantly classic or submacular haemorrhage) were significantly associated with visual improvement (coefficient of regression B = 26.8, p<0.001 and B = 14.9 with p = 0.045 respectively). There were no significant independent factors which predicted a final distance logMAR visual acuity of 1.3 (20/400) or any arbitrary definition of blindness. Conclusions: The study showed that it was possible to select cases that were more likely to experience an improvement in vision following MRS.
Persistent Identifierhttp://hdl.handle.net/10722/146280
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, Den_HK
dc.contributor.authorStanga, Pen_HK
dc.contributor.authorBriggs, Men_HK
dc.contributor.authorLenfestey, Pen_HK
dc.contributor.authorLancaster, Een_HK
dc.contributor.authorLi, KKen_HK
dc.contributor.authorLim, KSen_HK
dc.contributor.authorGroenewald, Cen_HK
dc.date.accessioned2012-04-10T01:49:55Z-
dc.date.available2012-04-10T01:49:55Z-
dc.date.issued2004en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2004, v. 88 n. 2, p. 186-190en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146280-
dc.description.abstractBackground: To date there has been no randomised controlled trial demonstrating the safety and efficacy of macular relocation surgery (MRS) for age related macular degeneration (AMD). Vision can be improved in some patients and made worse in others despite successful surgery or because of complications. Purpose: To determine which patients would benefit from MRS. Methods: Twenty nine patients with exudative AMD took part in a prospective, non-comparative, interventional study. Macular relocation surgery involved phacoemulsification, vitrectomy, 360° retinotomy, excision of choroidal neovascular membrane, and macular relocation using an infusion of 5-fluorouracil and low molecular weight heparin as adjuvant to prevent proliferative vitreoretinopathy. Patients underwent protocol refraction preoperotively and six-monthly postoperatively by designated optometrists. Preoperotive fundus fluorescein angiograms were read by masked observers and the lesions were classified according to a set protocol. The main outcome measures were visual improvement, final vision of better than 20/400, reading speed, critical print size. Logistic and multiple stepwise linear regressions were used to identify independent factors which predicted the main outcomes. Results: Preoperative visual acuity (20/120 or worse) and lesion type (predominantly classic or submacular haemorrhage) were significantly associated with visual improvement (coefficient of regression B = 26.8, p<0.001 and B = 14.9 with p = 0.045 respectively). There were no significant independent factors which predicted a final distance logMAR visual acuity of 1.3 (20/400) or any arbitrary definition of blindness. Conclusions: The study showed that it was possible to select cases that were more likely to experience an improvement in vision following MRS.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChemotherapy, Adjuvanten_US
dc.subject.meshChoroidal Neovascularization - Prevention & Controlen_US
dc.subject.meshFluorouracil - Therapeutic Useen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHeparin, Low-Molecular-Weight - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMacula Lutea - Surgeryen_US
dc.subject.meshMacular Degeneration - Surgeryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPatient Selectionen_US
dc.subject.meshPhacoemulsificationen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVisual Acuityen_US
dc.subject.meshVitrectomyen_US
dc.subject.meshVitreoretinopathy, Proliferative - Prevention & Controlen_US
dc.titleCase selection in macular relocation surgery for age related macular degenerationen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1136/bjo.2003.019273en_HK
dc.identifier.pmid14736769-
dc.identifier.pmcidPMC1772001-
dc.identifier.scopuseid_2-s2.0-0942279526en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0942279526&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue2en_HK
dc.identifier.spage186en_HK
dc.identifier.epage190en_HK
dc.identifier.isiWOS:000188302800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridStanga, P=6602197864en_HK
dc.identifier.scopusauthoridBriggs, M=17933456800en_HK
dc.identifier.scopusauthoridLenfestey, P=15837025000en_HK
dc.identifier.scopusauthoridLancaster, E=7004527741en_HK
dc.identifier.scopusauthoridLi, KK=7404990010en_HK
dc.identifier.scopusauthoridLim, KS=22955999500en_HK
dc.identifier.scopusauthoridGroenewald, C=6601917086en_HK

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