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Article: Pathobiology of epiretinal and subretinal membranes: Possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC)

TitlePathobiology of epiretinal and subretinal membranes: Possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC)
Authors
KeywordsEpiretinal membrane
Osteonectin
Proliferative vitreoretinopathy
Scatter factor/hepatocyte growth factor
SPARC
Subretinal mebrane
Thrombospondin 1
Issue Date2002
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eye
Citation
Eye, 2002, v. 16 n. 4, p. 393-403 How to Cite?
AbstractEpiretinal and subretinal membranes are fibrocellular proliferations which form on the surfaces of the neuroretina as a sequel to a variety of ocular diseases. When these proliferations complicate rhegmatogenous retinal detachment (a condition known as proliferative vitreoretinopathy or PVR), the membranes often contain numerous retinal pigment epithelial (RPE) cells and a variety of extracellular proteins. The extracellular proteins include adhesive proteins like collagen, laminin and fibronectin. In addition, several matricellular proteins with potential counter-adhesive functions are present in the membranes. Two such matricellular proteins, thrombospondin 1 and osteonectin (or SPARC: Secreted Protein Acidic and Rich in Cysteine), tend to be codistributed with the RPE cells in PVR membranes. By virtue of their counter-adhesive properties, thrombospondin 1 and SPARC may reduce RPE cell-matrix adhesion and so permit key RPE cellular activities (for example, migration or shape change) in periretinal membrane development. Furthermore, within a 'cocktail' containing other proteins such as the metalloproteinases and growth factors like the scatter factor/hepatocyte growth factor family, matricellular proteins may play a role in the RPE cell dissociation from Bruch's membrane, which characterises early PVR.
Persistent Identifierhttp://hdl.handle.net/10722/146264
ISSN
2015 Impact Factor: 2.213
2015 SCImago Journal Rankings: 1.132
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHiscott, Pen_HK
dc.contributor.authorHagan, Sen_HK
dc.contributor.authorHeathcote, Len_HK
dc.contributor.authorSheridan, CMen_HK
dc.contributor.authorGroenewald, CPen_HK
dc.contributor.authorGrierson, Ien_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorParaoan, Len_HK
dc.date.accessioned2012-04-10T01:49:47Z-
dc.date.available2012-04-10T01:49:47Z-
dc.date.issued2002en_HK
dc.identifier.citationEye, 2002, v. 16 n. 4, p. 393-403en_HK
dc.identifier.issn0950-222Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146264-
dc.description.abstractEpiretinal and subretinal membranes are fibrocellular proliferations which form on the surfaces of the neuroretina as a sequel to a variety of ocular diseases. When these proliferations complicate rhegmatogenous retinal detachment (a condition known as proliferative vitreoretinopathy or PVR), the membranes often contain numerous retinal pigment epithelial (RPE) cells and a variety of extracellular proteins. The extracellular proteins include adhesive proteins like collagen, laminin and fibronectin. In addition, several matricellular proteins with potential counter-adhesive functions are present in the membranes. Two such matricellular proteins, thrombospondin 1 and osteonectin (or SPARC: Secreted Protein Acidic and Rich in Cysteine), tend to be codistributed with the RPE cells in PVR membranes. By virtue of their counter-adhesive properties, thrombospondin 1 and SPARC may reduce RPE cell-matrix adhesion and so permit key RPE cellular activities (for example, migration or shape change) in periretinal membrane development. Furthermore, within a 'cocktail' containing other proteins such as the metalloproteinases and growth factors like the scatter factor/hepatocyte growth factor family, matricellular proteins may play a role in the RPE cell dissociation from Bruch's membrane, which characterises early PVR.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eyeen_HK
dc.relation.ispartofEyeen_HK
dc.subjectEpiretinal membraneen_HK
dc.subjectOsteonectinen_HK
dc.subjectProliferative vitreoretinopathyen_HK
dc.subjectScatter factor/hepatocyte growth factoren_HK
dc.subjectSPARCen_HK
dc.subjectSubretinal mebraneen_HK
dc.subjectThrombospondin 1en_HK
dc.subject.meshEpiretinal Membrane - Metabolism - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshOsteonectin - Physiologyen_US
dc.subject.meshPigment Epithelium Of Eye - Pathologyen_US
dc.subject.meshThrombospondin 1 - Physiologyen_US
dc.subject.meshVitreoretinopathy, Proliferative - Metabolismen_US
dc.titlePathobiology of epiretinal and subretinal membranes: Possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC)en_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1038/sj.eye.6700196en_HK
dc.identifier.pmid12101446-
dc.identifier.scopuseid_2-s2.0-0036326822en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036326822&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage393en_HK
dc.identifier.epage403en_HK
dc.identifier.isiWOS:000177383200009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHiscott, P=7006368693en_HK
dc.identifier.scopusauthoridHagan, S=7003335246en_HK
dc.identifier.scopusauthoridHeathcote, L=15024794900en_HK
dc.identifier.scopusauthoridSheridan, CM=7004974390en_HK
dc.identifier.scopusauthoridGroenewald, CP=6601917086en_HK
dc.identifier.scopusauthoridGrierson, I=7005212606en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridParaoan, L=6602257517en_HK

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