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Article: Vitreous penetration of levofloxacin in the uninflamed phakic human eye

TitleVitreous penetration of levofloxacin in the uninflamed phakic human eye
Authors
Issue Date2002
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2002, v. 86 n. 4, p. 387-389 How to Cite?
AbstractAims: To assess the vitreous penetration of oral levofloxacin (a new fluoroquinolone antibiotic with improved Gram positive activity) in uninflamed phakic eyes. Methods: 15 patients for macula hole surgery were recruited to the study. 10 received a single 500 mg dose of levofloxacin by mouth preoperatively. Five acted as controls. Serum and undiluted vitreous samples were obtained at surgery and analysed by HPLC. Results: Levofloxacin was detectable 2.5 hours after administration in the vitreous. A peak concentration of 1.6 μg/ml (or mg/l) was measured between 2.5 and 4 hours post-dose. Conclusion: Oral levofloxacin reaches the vitreous rapidly in the uninflamed phakic eye. Levels did not reach MIC 90 for the commonest infecting organisms. Nevertheless, levofloxacin would be expected to be active against a higher proportion of infecting organisms than either ciprofloxacin or ofloxacin.
Persistent Identifierhttp://hdl.handle.net/10722/146263
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHerbert, ENen_HK
dc.contributor.authorPearce, IAen_HK
dc.contributor.authorMcGalliard, Jen_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorGroenewald, Cen_HK
dc.date.accessioned2012-04-10T01:49:47Z-
dc.date.available2012-04-10T01:49:47Z-
dc.date.issued2002en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2002, v. 86 n. 4, p. 387-389en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146263-
dc.description.abstractAims: To assess the vitreous penetration of oral levofloxacin (a new fluoroquinolone antibiotic with improved Gram positive activity) in uninflamed phakic eyes. Methods: 15 patients for macula hole surgery were recruited to the study. 10 received a single 500 mg dose of levofloxacin by mouth preoperatively. Five acted as controls. Serum and undiluted vitreous samples were obtained at surgery and analysed by HPLC. Results: Levofloxacin was detectable 2.5 hours after administration in the vitreous. A peak concentration of 1.6 μg/ml (or mg/l) was measured between 2.5 and 4 hours post-dose. Conclusion: Oral levofloxacin reaches the vitreous rapidly in the uninflamed phakic eye. Levels did not reach MIC 90 for the commonest infecting organisms. Nevertheless, levofloxacin would be expected to be active against a higher proportion of infecting organisms than either ciprofloxacin or ofloxacin.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Infective Agents - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOfloxacin - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshRetinal Perforations - Surgeryen_US
dc.subject.meshTabletsen_US
dc.subject.meshVitrectomy - Methodsen_US
dc.subject.meshVitreous Body - Metabolismen_US
dc.titleVitreous penetration of levofloxacin in the uninflamed phakic human eyeen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1136/bjo.86.4.387en_HK
dc.identifier.pmid11914204-
dc.identifier.pmcidPMC1771086-
dc.identifier.scopuseid_2-s2.0-0036218397en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036218397&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue4en_HK
dc.identifier.spage387en_HK
dc.identifier.epage389en_HK
dc.identifier.isiWOS:000174940600009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHerbert, EN=7006358782en_HK
dc.identifier.scopusauthoridPearce, IA=35345778700en_HK
dc.identifier.scopusauthoridMcGalliard, J=7003380072en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridGroenewald, C=6601917086en_HK

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