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Article: Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery

TitleUse of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajo
Citation
American Journal Of Ophthalmology, 2002, v. 133 n. 1, p. 95-101 How to Cite?
AbstractPURPOSE: To report the use of perfluorohexyloctane, a liquid semifluorinated alkane that is heavier than water, as an internal tamponade agent in surgery for complicated retinal detachments. DESIGN: A consecutive interventional case series from three study centers. METHODS: In 23 consecutive eyes (23 patients, 19 men and four women, mean ± standard deviation (SD) age of 58.5 years ± 16.1) perfluorohexyloctane was used for long-term internal tamponade. Included were eyes with complicated retinal detachment involving the lower two quadrants of the fundus. Excluded were patients with diseases in the fellow eye or severe systemic disease. A pars plana vitrectomy was performed, including membrane peeling and retinotomy where necessary. RESULTS: The mean duration for perfluorohexyloctane being left in situ was 76 days (SD 37.64) (range, 35-202 days). Four weeks following the removal of perfluorohexyloctane 19 of the 23 patients had total reattachment of the retina; three eyes had a recurrence of retinal detachment. One patient was lost to follow-up. The mean follow-up after perfluorohexyloctane removal was 97 days (range, 48 to 169 days). Cataract formation or progression was noted in nine of the 10 eyes. There were two cases with high intraocular pressures. Dispersion into small droplets was observed as early as 3 days postoperatively in three of the 23 patients. At least 12 of the 23 patients had an obvious dispersion by the time of perfluorohexyloctane removal. There was no sign of optic atrophy, retinal necrosis, or retinal vascular occlusion. CONCLUSION: Perfluorohexyloctane was tolerated as a long-term internal tamponade agent without obvious signs of damage to the retina or optic disk. Of all the complications noted, the most common was that of dispersion of the perfluorohexyloctane bubble into droplets. © 2002 by Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/146262
ISSN
2015 Impact Factor: 3.831
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKirchhof, Ben_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorVan Meurs, Jen_HK
dc.contributor.authorHilgers, RDen_HK
dc.contributor.authorMacek, Men_HK
dc.contributor.authorLois, Nen_HK
dc.contributor.authorSchrage, NFen_HK
dc.date.accessioned2012-04-10T01:49:46Z-
dc.date.available2012-04-10T01:49:46Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Ophthalmology, 2002, v. 133 n. 1, p. 95-101en_HK
dc.identifier.issn0002-9394en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146262-
dc.description.abstractPURPOSE: To report the use of perfluorohexyloctane, a liquid semifluorinated alkane that is heavier than water, as an internal tamponade agent in surgery for complicated retinal detachments. DESIGN: A consecutive interventional case series from three study centers. METHODS: In 23 consecutive eyes (23 patients, 19 men and four women, mean ± standard deviation (SD) age of 58.5 years ± 16.1) perfluorohexyloctane was used for long-term internal tamponade. Included were eyes with complicated retinal detachment involving the lower two quadrants of the fundus. Excluded were patients with diseases in the fellow eye or severe systemic disease. A pars plana vitrectomy was performed, including membrane peeling and retinotomy where necessary. RESULTS: The mean duration for perfluorohexyloctane being left in situ was 76 days (SD 37.64) (range, 35-202 days). Four weeks following the removal of perfluorohexyloctane 19 of the 23 patients had total reattachment of the retina; three eyes had a recurrence of retinal detachment. One patient was lost to follow-up. The mean follow-up after perfluorohexyloctane removal was 97 days (range, 48 to 169 days). Cataract formation or progression was noted in nine of the 10 eyes. There were two cases with high intraocular pressures. Dispersion into small droplets was observed as early as 3 days postoperatively in three of the 23 patients. At least 12 of the 23 patients had an obvious dispersion by the time of perfluorohexyloctane removal. There was no sign of optic atrophy, retinal necrosis, or retinal vascular occlusion. CONCLUSION: Perfluorohexyloctane was tolerated as a long-term internal tamponade agent without obvious signs of damage to the retina or optic disk. Of all the complications noted, the most common was that of dispersion of the perfluorohexyloctane bubble into droplets. © 2002 by Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajoen_HK
dc.relation.ispartofAmerican Journal of Ophthalmologyen_HK
dc.subject.meshCataract - Chemically Induceden_US
dc.subject.meshEmulsionsen_US
dc.subject.meshEndothelium, Corneal - Drug Effectsen_US
dc.subject.meshEpiretinal Membrane - Surgeryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorocarbons - Adverse Effects - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraocular Pressure - Drug Effectsen_US
dc.subject.meshLens, Crystalline - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOptic Disk - Drug Effectsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRetina - Drug Effectsen_US
dc.subject.meshRetinal Detachment - Surgeryen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVisual Acuity - Drug Effectsen_US
dc.subject.meshVitrectomyen_US
dc.titleUse of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgeryen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0002-9394(01)01295-8en_HK
dc.identifier.pmid11755844-
dc.identifier.scopuseid_2-s2.0-0036146936en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036146936&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue1en_HK
dc.identifier.spage95en_HK
dc.identifier.epage101en_HK
dc.identifier.isiWOS:000173144600011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKirchhof, B=7006285825en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridVan Meurs, J=7005539446en_HK
dc.identifier.scopusauthoridHilgers, RD=20433430700en_HK
dc.identifier.scopusauthoridMacek, M=7102721895en_HK
dc.identifier.scopusauthoridLois, N=7003969757en_HK
dc.identifier.scopusauthoridSchrage, NF=7004065696en_HK

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