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Article: Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant

TitleStabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant
Authors
Issue Date2000
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2000, v. 84 n. 7, p. 736-740 How to Cite?
AbstractBackground/aims - Simultaneous pancreas and kidney transplantation (SPK) has become an important option in selected IDDM patients with end stage renal disease (ESRD). Successful SPK transplants are associated with long term normoglycaemic control and improved quality of life. However, debate still continues on the benefit to patients in terms of stabilisation or amelioration of diabetic retinopathy. The progression of diabetic retinopathy (DR) in a cohort of 20 SPK transplant patients is reported. Methods - All patients were reviewed postoperatively with corrected visual acuity, slit lamp examination, and fundal biomicroscopy. Preoperative data were collected retrospectively and DR was considered unstable if there had been a drop in Snellen acuity greater than three lines or a need for laser photocoagulation or vitrectomy in the 2 years preoperatively. Results - 20 patients who received SPK transplants between March 1983 and April 1994 were reviewed (mean age 35.1 years; mean duration of IDDM = 24.6 years). 17 patients still had functioning grafts at a mean follow up of 5.1 years. Nine of these patients had unstable DR before transplantation. Of these, 89% (8/9) had stabilised DR following transplantation with only a single case requiring laser photocoagulation. Of the eight patients that had stable DR before transplantation all had stable DR following transplantation. 41% of cases (7/17) required cataract surgery during the follow up period. Conclusions - Advanced diabetic retinopathy is present in a high proportion of cases managed with SPK transplant as a consequence of the duration of IDDM and the presence of ESRD. More than 90% of cases have stable DR following transplant.
Persistent Identifierhttp://hdl.handle.net/10722/146249
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPearce, IAen_HK
dc.contributor.authorIlango, Ben_HK
dc.contributor.authorSells, RAen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:49:41Z-
dc.date.available2012-04-10T01:49:41Z-
dc.date.issued2000en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2000, v. 84 n. 7, p. 736-740en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146249-
dc.description.abstractBackground/aims - Simultaneous pancreas and kidney transplantation (SPK) has become an important option in selected IDDM patients with end stage renal disease (ESRD). Successful SPK transplants are associated with long term normoglycaemic control and improved quality of life. However, debate still continues on the benefit to patients in terms of stabilisation or amelioration of diabetic retinopathy. The progression of diabetic retinopathy (DR) in a cohort of 20 SPK transplant patients is reported. Methods - All patients were reviewed postoperatively with corrected visual acuity, slit lamp examination, and fundal biomicroscopy. Preoperative data were collected retrospectively and DR was considered unstable if there had been a drop in Snellen acuity greater than three lines or a need for laser photocoagulation or vitrectomy in the 2 years preoperatively. Results - 20 patients who received SPK transplants between March 1983 and April 1994 were reviewed (mean age 35.1 years; mean duration of IDDM = 24.6 years). 17 patients still had functioning grafts at a mean follow up of 5.1 years. Nine of these patients had unstable DR before transplantation. Of these, 89% (8/9) had stabilised DR following transplantation with only a single case requiring laser photocoagulation. Of the eight patients that had stable DR before transplantation all had stable DR following transplantation. 41% of cases (7/17) required cataract surgery during the follow up period. Conclusions - Advanced diabetic retinopathy is present in a high proportion of cases managed with SPK transplant as a consequence of the duration of IDDM and the presence of ESRD. More than 90% of cases have stable DR following transplant.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.subject.meshAdulten_US
dc.subject.meshAnti-Inflammatory Agents - Adverse Effectsen_US
dc.subject.meshCataract - Chemically Induceden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Surgeryen_US
dc.subject.meshDiabetic Retinopathy - Etiologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft Survivalen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Transplantation - Methodsen_US
dc.subject.meshLight Coagulationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPancreas Transplantation - Methodsen_US
dc.subject.meshSteroidsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVisual Acuityen_US
dc.subject.meshVitrectomyen_US
dc.titleStabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplanten_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1136/bjo.84.7.736en_HK
dc.identifier.pmid10873985-
dc.identifier.pmcidPMC1723560-
dc.identifier.scopuseid_2-s2.0-0033920881en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033920881&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume84en_HK
dc.identifier.issue7en_HK
dc.identifier.spage736en_HK
dc.identifier.epage740en_HK
dc.identifier.isiWOS:000088067000016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPearce, IA=35345778700en_HK
dc.identifier.scopusauthoridIlango, B=6602719072en_HK
dc.identifier.scopusauthoridSells, RA=7006091381en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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