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Article: Immunophenotypic shift in a case of mycosis fungoides with vitreous invasion

TitleImmunophenotypic shift in a case of mycosis fungoides with vitreous invasion
Authors
Issue Date2000
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archopthalmol.com
Citation
Archives Of Ophthalmology, 2000, v. 118 n. 12, p. 1692-1694 How to Cite?
AbstractThe case of an 82-year-old man who developed intraocular extension from mycosis fungoides, a cutaneous T-cell lymphoma, is presented. The patient died soon after intra-ocular involvement occurred. Immunohistochemistry of a skin biopsy, taken early in the course of the disease, disclosed a predominance of T cells with a helper/inducer phenotype (CD4+). However, an intraocular infiltrate obtained 7 years later contained mostly T cells with a suppressor/cytotoxic phenotype (CD8+). The occurrence of ocular invasion, the change in immunophenotype, and the predominant proliferation of CD8+ lymphocytes may have been related to the poor outcome in this patient.
Persistent Identifierhttp://hdl.handle.net/10722/146247
ISSN
2014 Impact Factor: 4.399
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLois, Nen_HK
dc.contributor.authorHiscott, PSen_HK
dc.contributor.authorNash, Jen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:49:40Z-
dc.date.available2012-04-10T01:49:40Z-
dc.date.issued2000en_HK
dc.identifier.citationArchives Of Ophthalmology, 2000, v. 118 n. 12, p. 1692-1694en_HK
dc.identifier.issn0003-9950en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146247-
dc.description.abstractThe case of an 82-year-old man who developed intraocular extension from mycosis fungoides, a cutaneous T-cell lymphoma, is presented. The patient died soon after intra-ocular involvement occurred. Immunohistochemistry of a skin biopsy, taken early in the course of the disease, disclosed a predominance of T cells with a helper/inducer phenotype (CD4+). However, an intraocular infiltrate obtained 7 years later contained mostly T cells with a suppressor/cytotoxic phenotype (CD8+). The occurrence of ocular invasion, the change in immunophenotype, and the predominant proliferation of CD8+ lymphocytes may have been related to the poor outcome in this patient.en_HK
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archopthalmol.comen_HK
dc.relation.ispartofArchives of Ophthalmologyen_HK
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshCd4-Cd8 Ratioen_US
dc.subject.meshEye Neoplasms - Immunology - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshMaleen_US
dc.subject.meshMycosis Fungoides - Immunology - Pathologyen_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshSkin Neoplasms - Immunology - Pathologyen_US
dc.subject.meshT-Lymphocytes, Cytotoxic - Immunology - Pathologyen_US
dc.subject.meshT-Lymphocytes, Helper-Inducer - Immunology - Pathologyen_US
dc.subject.meshT-Lymphocytes, Regulatory - Immunology - Pathologyen_US
dc.subject.meshVitreous Body - Immunology - Pathologyen_US
dc.titleImmunophenotypic shift in a case of mycosis fungoides with vitreous invasionen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11115267-
dc.identifier.scopuseid_2-s2.0-0033673754en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033673754&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume118en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1692en_HK
dc.identifier.epage1694en_HK
dc.identifier.isiWOS:000165738800014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLois, N=7003969757en_HK
dc.identifier.scopusauthoridHiscott, PS=7006368693en_HK
dc.identifier.scopusauthoridNash, J=7202698586en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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