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Article: Intravitreal penetration of teicoplanin

TitleIntravitreal penetration of teicoplanin
Authors
KeywordsEndophthalmitis
Glycopeptide
Staphylococcus
Teicoplanin
Vancomycin
Vitrectomy
Issue Date1998
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eye
Citation
Eye, 1998, v. 12 n. 2, p. 252-255 How to Cite?
AbstractTeicoplanin is a glycopeptide antibiotic, similar to vancomycin, but safer and better tolerated. The purpose of this study was to evaluate the penetration of teicoplanin into the vitreous when administered topically and intravenously. Twenty-five patients undergoing routine vitrectomy were recruited. Twenty were given intravenous teicoplanin: five 1 h pre-operatively, five 12 h pre-operatively, five 24 h pre-operatively and five 24 h as well as 48 h pre-operatively. Five received teicoplanin drops half-hourly for the 6 h immediately preceding vitrectomy. Undiluted vitreous specimens were obtained at the beginning of each vitrectomy procedure. Teicoplanin levels were measured using a biological assay with Staphylococcus aureus as the indicator organism. Teicoplanin activity was detected in 8 of the 20 specimens from those patients receiving the intravenous antibiotic. Teicoplanin did not penetrate readily into the vitreous cavities in these eyes despite the blood-ocular barrier being compromised in some patients, although there was evidence of accumulation with time. No activity was detected in the vitreous of those patients who received topical teicoplanin.
Persistent Identifierhttp://hdl.handle.net/10722/146239
ISSN
2015 Impact Factor: 2.213
2015 SCImago Journal Rankings: 1.132
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBriggs, MCen_HK
dc.contributor.authorMcDonald, Pen_HK
dc.contributor.authorBourke, Ren_HK
dc.contributor.authorSmith, Gen_HK
dc.contributor.authorMcGalliard, JNen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:49:37Z-
dc.date.available2012-04-10T01:49:37Z-
dc.date.issued1998en_HK
dc.identifier.citationEye, 1998, v. 12 n. 2, p. 252-255en_HK
dc.identifier.issn0950-222Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/146239-
dc.description.abstractTeicoplanin is a glycopeptide antibiotic, similar to vancomycin, but safer and better tolerated. The purpose of this study was to evaluate the penetration of teicoplanin into the vitreous when administered topically and intravenously. Twenty-five patients undergoing routine vitrectomy were recruited. Twenty were given intravenous teicoplanin: five 1 h pre-operatively, five 12 h pre-operatively, five 24 h pre-operatively and five 24 h as well as 48 h pre-operatively. Five received teicoplanin drops half-hourly for the 6 h immediately preceding vitrectomy. Undiluted vitreous specimens were obtained at the beginning of each vitrectomy procedure. Teicoplanin levels were measured using a biological assay with Staphylococcus aureus as the indicator organism. Teicoplanin activity was detected in 8 of the 20 specimens from those patients receiving the intravenous antibiotic. Teicoplanin did not penetrate readily into the vitreous cavities in these eyes despite the blood-ocular barrier being compromised in some patients, although there was evidence of accumulation with time. No activity was detected in the vitreous of those patients who received topical teicoplanin.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/eyeen_HK
dc.relation.ispartofEyeen_HK
dc.subjectEndophthalmitisen_HK
dc.subjectGlycopeptideen_HK
dc.subjectStaphylococcusen_HK
dc.subjectTeicoplaninen_HK
dc.subjectVancomycinen_HK
dc.subjectVitrectomyen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnti-Bacterial Agents - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOphthalmic Solutionsen_US
dc.subject.meshTeicoplanin - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshVitrectomyen_US
dc.subject.meshVitreous Body - Metabolismen_US
dc.titleIntravitreal penetration of teicoplaninen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9683949-
dc.identifier.scopuseid_2-s2.0-0031776394en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031776394&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue2en_HK
dc.identifier.spage252en_HK
dc.identifier.epage255en_HK
dc.identifier.isiWOS:000073944600019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBriggs, MC=17933456800en_HK
dc.identifier.scopusauthoridMcDonald, P=20535134300en_HK
dc.identifier.scopusauthoridBourke, R=7005206913en_HK
dc.identifier.scopusauthoridSmith, G=15721401800en_HK
dc.identifier.scopusauthoridMcGalliard, JN=7003380072en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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