Article: Hyperglycaemia and vitamin D: a systematic overview

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TitleHyperglycaemia and vitamin D: a systematic overview
AuthorsThomas, GN
Scragg, R5
Jiang, CQ8
Chan, W2
März, W1 3 7
Pilz, S7
Kim, HC4
Tomlinson, B9
Bosch, J6
Lam, TH2
Cheung, BMY6
Cheng, KK6
KeywordsCalcium
Hyperglycaemia
Parathyroid hormone
Vascular disease vitamin D
Issue Date2012
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdr/index.htm
CitationCurrent Diabetes Reviews, 2012, v. 8 n. 1, p. 18-31 [How to Cite?]
DOI: http://dx.doi.org/10.2174/157339912798829223
AbstractVitamin D plays a role in a range of functions that may impact on glycaemic control. In this study we systematically report on clinical studies evaluating the impact of vitamin D on aspects of hyperglycaemia in non-pregnant adults. A total of 1,294 articles, of which 417 were reviews, were identified. No well-designed randomised, controlled trials were identified that specifically investigated the effects of vitamin D supplementation on glucose and insulin concentrations. The majority of the studies that are available were poorly designed, having limited numbers, short study duration, or were conducted in volunteers with normal baseline, as measured by 25-hydroxyvitamin D (25(OH)D), concentrations or used inadequate doses of the supplements to normalise vitamin D concentrations, or used inappropriate analyses. Most studies did not observe improvements in glycaemia, with few exceptions. The results were more equivocal for aspects of insulin resistance. Most found no benefit on measures of insulin resistance, although some did. However, more studies described improved insulin release, although data from the studies to date are really inadequate to provide any reliable conclusions. Well-conducted randomised, controlled trials with adequate vitamin D doses are required to effectively assess whether this vitamin can reduce the incidence of diabetes. © 2012 Bentham Science Publishers.
ISSN1573-3998
2011 SCImago Journal Rankings: 0.294
DOIhttp://dx.doi.org/10.2174/157339912798829223
DC Field
Value
dc.contributor.authorThomas, GN
dc.contributor.authorScragg, R
dc.contributor.authorJiang, CQ
dc.contributor.authorChan, W
dc.contributor.authorMärz, W
dc.contributor.authorPilz, S
dc.contributor.authorKim, HC
dc.contributor.authorTomlinson, B
dc.contributor.authorBosch, J
dc.contributor.authorLam, TH
dc.contributor.authorCheung, BMY
dc.contributor.authorCheng, KK
dc.date.accessioned2012-03-27T09:04:44Z
dc.date.available2012-03-27T09:04:44Z
dc.date.issued2012
dc.description.abstractVitamin D plays a role in a range of functions that may impact on glycaemic control. In this study we systematically report on clinical studies evaluating the impact of vitamin D on aspects of hyperglycaemia in non-pregnant adults. A total of 1,294 articles, of which 417 were reviews, were identified. No well-designed randomised, controlled trials were identified that specifically investigated the effects of vitamin D supplementation on glucose and insulin concentrations. The majority of the studies that are available were poorly designed, having limited numbers, short study duration, or were conducted in volunteers with normal baseline, as measured by 25-hydroxyvitamin D (25(OH)D), concentrations or used inadequate doses of the supplements to normalise vitamin D concentrations, or used inappropriate analyses. Most studies did not observe improvements in glycaemia, with few exceptions. The results were more equivocal for aspects of insulin resistance. Most found no benefit on measures of insulin resistance, although some did. However, more studies described improved insulin release, although data from the studies to date are really inadequate to provide any reliable conclusions. Well-conducted randomised, controlled trials with adequate vitamin D doses are required to effectively assess whether this vitamin can reduce the incidence of diabetes. © 2012 Bentham Science Publishers.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationCurrent Diabetes Reviews, 2012, v. 8 n. 1, p. 18-31 [How to Cite?]
DOI: http://dx.doi.org/10.2174/157339912798829223
dc.identifier.doihttp://dx.doi.org/10.2174/157339912798829223
dc.identifier.epage31
dc.identifier.hkuros199114
dc.identifier.issn1573-3998
2011 SCImago Journal Rankings: 0.294
dc.identifier.issue1
dc.identifier.pmid22352447
dc.identifier.scopuseid_2-s2.0-84862910469
dc.identifier.spage18
dc.identifier.urihttp://hdl.handle.net/10722/145987
dc.identifier.volume8
dc.languageeng
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdr/index.htm
dc.publisher.placeNetherlands
dc.relation.ispartofCurrent Diabetes Reviews
dc.subject.meshDietary supplements
dc.subject.meshHyperglycemia - drug therapy
dc.subject.meshInsulin resistance
dc.subject.meshVitamin D - analogs and derivatives - blood - therapeutic use
dc.subject.meshVitamins - blood - therapeutic use
dc.subjectCalcium
dc.subjectHyperglycaemia
dc.subjectParathyroid hormone
dc.subjectVascular disease vitamin D
dc.titleHyperglycaemia and vitamin D: a systematic overview
dc.typeArticle
Author Affiliations
  1. Synlab Services GmbH
  2. The University of Hong Kong
  3. Universitätsklinikum Mannheim
  4. Yonsei University College of Medicine
  5. University of Auckland
  6. University of Birmingham
  7. Medizinische Universitat Graz
  8. Guangzhou No. 12 Hospital
  9. Chinese University of Hong Kong