Article: Pubertal muscle mass and diabetes markers in Chinese adolescents
| Title | Pubertal muscle mass and diabetes markers in Chinese adolescents | ||||||||||||||||
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| Authors | Lin, SL1 Lee, SL3 Hui, LL1 Au Yeung, SL1 Tse, MA2 Leung, GM1 Schooling, CM1 | ||||||||||||||||
| Issue Date | 2012 | ||||||||||||||||
| Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1042-0533/ | ||||||||||||||||
| Citation | American Journal Of Human Biology, 2012, v. 24 n. 2, p. 183-185 [How to Cite?] DOI: http://dx.doi.org/10.1002/ajhb.22210 | ||||||||||||||||
| Abstract | Objectives: Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents. Methods: In 40 adolescents (20 boys and 20 girls, age 12.9 ± 0.1 years) from Hong Kong's "Children of 1997" birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan. Results: Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (-0.04 mmol/l, 95% CI -0.08 to -0.01 per kg muscle mass) adjusted for sex and fat mass. Conclusions: Environmentally driven muscle mass acquisition at puberty could influence diabetes. © 2012 Wiley Periodicals, Inc. | ||||||||||||||||
| ISSN | 1042-0533 2011 Impact Factor: 2.267 2011 SCImago Journal Rankings: 0.135 | ||||||||||||||||
| DOI | http://dx.doi.org/10.1002/ajhb.22210 | ||||||||||||||||
| ISI Accession Number ID | WOS:000299997500013
Funding Information: This study was originally supported by Health Care and Promotion Fund, Health and Welfare Bureau, Government of Hong Kong; Contract grant number: HCPF #216106. It was further supported by Health and Health Services Research Fund; Contract grant number: HHSRF #03040771, Research Fund for the Control of Infectious Diseases in Hong Kong, RFCID #06060592, Government of the Hong Kong SAR and the University Research Committee Strategic Research Theme of Public Health Granted Research, The University of Hong Kong. | ||||||||||||||||
| References | References in Scopus | ||||||||||||||||
| Grants | Impact of breastfeeding on hospitalizations from infectious diseases in Hong Kong Chinese children up to eight years of age Short- and medium-term outcomes of accelerated infant growth in Hong Kong Chinese birth cohort |
| dc.contributor.author | Lin, SL | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lee, SL | ||||||||||||||||
| dc.contributor.author | Hui, LL | ||||||||||||||||
| dc.contributor.author | Au Yeung, SL | ||||||||||||||||
| dc.contributor.author | Tse, MA | ||||||||||||||||
| dc.contributor.author | Leung, GM | ||||||||||||||||
| dc.contributor.author | Schooling, CM | ||||||||||||||||
| dc.date.accessioned | 2012-03-27T09:01:51Z | ||||||||||||||||
| dc.date.available | 2012-03-27T09:01:51Z | ||||||||||||||||
| dc.date.issued | 2012 | ||||||||||||||||
| dc.description.abstract | Objectives: Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents. Methods: In 40 adolescents (20 boys and 20 girls, age 12.9 ± 0.1 years) from Hong Kong's "Children of 1997" birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan. Results: Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (-0.04 mmol/l, 95% CI -0.08 to -0.01 per kg muscle mass) adjusted for sex and fat mass. Conclusions: Environmentally driven muscle mass acquisition at puberty could influence diabetes. © 2012 Wiley Periodicals, Inc. | ||||||||||||||||
| dc.description.grant | Impact of breastfeeding on hospitalizations from infectious diseases in Hong Kong Chinese children up to eight years of age | ||||||||||||||||
| dc.description.grant | Short- and medium-term outcomes of accelerated infant growth in Hong Kong Chinese birth cohort | ||||||||||||||||
| dc.description.grantcode | 96216 | ||||||||||||||||
| dc.description.grantcode | 82101 | ||||||||||||||||
| dc.description.nature | link_to_subscribed_fulltext | ||||||||||||||||
| dc.identifier.citation | American Journal Of Human Biology, 2012, v. 24 n. 2, p. 183-185 [How to Cite?] DOI: http://dx.doi.org/10.1002/ajhb.22210 | ||||||||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1002/ajhb.22210 | ||||||||||||||||
| dc.identifier.epage | 185 | ||||||||||||||||
| dc.identifier.hkuros | 198830 | ||||||||||||||||
| dc.identifier.isi | WOS:000299997500013
Funding Information: This study was originally supported by Health Care and Promotion Fund, Health and Welfare Bureau, Government of Hong Kong; Contract grant number: HCPF #216106. It was further supported by Health and Health Services Research Fund; Contract grant number: HHSRF #03040771, Research Fund for the Control of Infectious Diseases in Hong Kong, RFCID #06060592, Government of the Hong Kong SAR and the University Research Committee Strategic Research Theme of Public Health Granted Research, The University of Hong Kong. | ||||||||||||||||
| dc.identifier.issn | 1042-0533 2011 Impact Factor: 2.267 2011 SCImago Journal Rankings: 0.135 | ||||||||||||||||
| dc.identifier.issue | 2 | ||||||||||||||||
| dc.identifier.pmid | 22287498 | ||||||||||||||||
| dc.identifier.scopus | eid_2-s2.0-84862786770 | ||||||||||||||||
| dc.identifier.spage | 183 | ||||||||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/145910 | ||||||||||||||||
| dc.identifier.volume | 24 | ||||||||||||||||
| dc.language | eng | ||||||||||||||||
| dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1042-0533/ | ||||||||||||||||
| dc.publisher.place | United States | ||||||||||||||||
| dc.relation.ispartof | American Journal of Human Biology | ||||||||||||||||
| dc.relation.references | References in Scopus | ||||||||||||||||
| dc.rights | American Journal of Human Biology. Copyright © John Wiley & Sons, Inc. | ||||||||||||||||
| dc.subject.mesh | Body Composition - physiology | ||||||||||||||||
| dc.subject.mesh | Diabetes Mellitus - etiology | ||||||||||||||||
| dc.subject.mesh | Muscle, Skeletal - anatomy and histology - physiology | ||||||||||||||||
| dc.subject.mesh | Puberty - physiology | ||||||||||||||||
| dc.subject.mesh | Testosterone - blood | ||||||||||||||||
| dc.title | Pubertal muscle mass and diabetes markers in Chinese adolescents | ||||||||||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- The University of Hong Kong
- Queen Mary Hospital Hong Kong