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Article: Pubertal muscle mass and diabetes markers in Chinese adolescents
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TitlePubertal muscle mass and diabetes markers in Chinese adolescents
 
AuthorsLin, SL1
Lee, SL3
Hui, LL1
Au Yeung, SL1
Tse, MA2
Leung, GM1
Schooling, CM1
 
Issue Date2012
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1042-0533/
 
CitationAmerican Journal Of Human Biology, 2012, v. 24 n. 2, p. 183-185 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajhb.22210
 
AbstractObjectives: Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents. Methods: In 40 adolescents (20 boys and 20 girls, age 12.9 ± 0.1 years) from Hong Kong's "Children of 1997" birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan. Results: Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (-0.04 mmol/l, 95% CI -0.08 to -0.01 per kg muscle mass) adjusted for sex and fat mass. Conclusions: Environmentally driven muscle mass acquisition at puberty could influence diabetes. © 2012 Wiley Periodicals, Inc.
 
ISSN1042-0533
2013 Impact Factor: 1.928
 
DOIhttp://dx.doi.org/10.1002/ajhb.22210
 
ISI Accession Number IDWOS:000299997500013
Funding AgencyGrant Number
Health Care and Promotion Fund
Health and Welfare Bureau, Government of Hong Kong216106
Health and Health Services Research Fund03040771
Research Fund for the Control of Infectious Diseases in Hong Kong, RFCID06060592
Government of the Hong Kong SAR
University Research Committee Strategic Research Theme of Public Health Granted Research
University of Hong Kong
Funding Information:

This study was originally supported by Health Care and Promotion Fund, Health and Welfare Bureau, Government of Hong Kong; Contract grant number: HCPF #216106. It was further supported by Health and Health Services Research Fund; Contract grant number: HHSRF #03040771, Research Fund for the Control of Infectious Diseases in Hong Kong, RFCID #06060592, Government of the Hong Kong SAR and the University Research Committee Strategic Research Theme of Public Health Granted Research, The University of Hong Kong.

 
ReferencesReferences in Scopus
 
GrantsImpact of breastfeeding on hospitalizations from infectious diseases in Hong Kong Chinese children up to eight years of age
Short- and medium-term outcomes of accelerated infant growth in Hong Kong Chinese birth cohort
 
DC FieldValue
dc.contributor.authorLin, SL
 
dc.contributor.authorLee, SL
 
dc.contributor.authorHui, LL
 
dc.contributor.authorAu Yeung, SL
 
dc.contributor.authorTse, MA
 
dc.contributor.authorLeung, GM
 
dc.contributor.authorSchooling, CM
 
dc.date.accessioned2012-03-27T09:01:51Z
 
dc.date.available2012-03-27T09:01:51Z
 
dc.date.issued2012
 
dc.description.abstractObjectives: Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents. Methods: In 40 adolescents (20 boys and 20 girls, age 12.9 ± 0.1 years) from Hong Kong's "Children of 1997" birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan. Results: Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (-0.04 mmol/l, 95% CI -0.08 to -0.01 per kg muscle mass) adjusted for sex and fat mass. Conclusions: Environmentally driven muscle mass acquisition at puberty could influence diabetes. © 2012 Wiley Periodicals, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Human Biology, 2012, v. 24 n. 2, p. 183-185 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajhb.22210
 
dc.identifier.doihttp://dx.doi.org/10.1002/ajhb.22210
 
dc.identifier.epage185
 
dc.identifier.hkuros198830
 
dc.identifier.isiWOS:000299997500013
Funding AgencyGrant Number
Health Care and Promotion Fund
Health and Welfare Bureau, Government of Hong Kong216106
Health and Health Services Research Fund03040771
Research Fund for the Control of Infectious Diseases in Hong Kong, RFCID06060592
Government of the Hong Kong SAR
University Research Committee Strategic Research Theme of Public Health Granted Research
University of Hong Kong
Funding Information:

This study was originally supported by Health Care and Promotion Fund, Health and Welfare Bureau, Government of Hong Kong; Contract grant number: HCPF #216106. It was further supported by Health and Health Services Research Fund; Contract grant number: HHSRF #03040771, Research Fund for the Control of Infectious Diseases in Hong Kong, RFCID #06060592, Government of the Hong Kong SAR and the University Research Committee Strategic Research Theme of Public Health Granted Research, The University of Hong Kong.

 
dc.identifier.issn1042-0533
2013 Impact Factor: 1.928
 
dc.identifier.issue2
 
dc.identifier.pmid22287498
 
dc.identifier.scopuseid_2-s2.0-84862786770
 
dc.identifier.spage183
 
dc.identifier.urihttp://hdl.handle.net/10722/145910
 
dc.identifier.volume24
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1042-0533/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Human Biology
 
dc.relation.projectImpact of breastfeeding on hospitalizations from infectious diseases in Hong Kong Chinese children up to eight years of age
 
dc.relation.projectShort- and medium-term outcomes of accelerated infant growth in Hong Kong Chinese birth cohort
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAmerican Journal of Human Biology. Copyright © John Wiley & Sons, Inc.
 
dc.subject.meshBody Composition - physiology
 
dc.subject.meshDiabetes Mellitus - etiology
 
dc.subject.meshMuscle, Skeletal - anatomy and histology - physiology
 
dc.subject.meshPuberty - physiology
 
dc.subject.meshTestosterone - blood
 
dc.titlePubertal muscle mass and diabetes markers in Chinese adolescents
 
dc.typeArticle
 
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<contributor.author>Lee, SL</contributor.author>
<contributor.author>Hui, LL</contributor.author>
<contributor.author>Au Yeung, SL</contributor.author>
<contributor.author>Tse, MA</contributor.author>
<contributor.author>Leung, GM</contributor.author>
<contributor.author>Schooling, CM</contributor.author>
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<description.abstract>Objectives: Diabetes is common in China despite a relatively nonobese population. We hypothesized that testosterone driven muscle mass acquisition at puberty may be relevant. We examined the associations of testosterone with muscle mass and of muscle mass with fasting glucose in Chinese adolescents. Methods: In 40 adolescents (20 boys and 20 girls, age 12.9 &#177; 0.1 years) from Hong Kong&apos;s &quot;Children of 1997&quot; birth cohort, we used multivariable linear regression to assess adjusted associations of testosterone and fasting glucose (from a morning blood sample) with muscle and fat mass from a dual-energy X-ray absorptiometry scan. Results: Testosterone was positively associated with muscle mass (0.05 kg, 95% confidence interval (CI) 0.01 to 0.09, per pg/ml testosterone). Muscle mass was associated with lower glucose (-0.04 mmol/l, 95% CI -0.08 to -0.01 per kg muscle mass) adjusted for sex and fat mass. Conclusions: Environmentally driven muscle mass acquisition at puberty could influence diabetes. &#169; 2012 Wiley Periodicals, Inc.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong