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Article: Effect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities

TitleEffect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese cities
Authors
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2011, v. 11 How to Cite?
AbstractBackground: Environmental factors have been associated with transmission and survival of influenza viruses but no studies have ever explored the role of environmental factors on severity of influenza infection.Methods: We applied a Poisson regression model to the mortality data of two Chinese metropolitan cities located within the subtropical zone, to calculate the influenza associated excess mortality risks during the periods with different levels of temperature and humidity.Results: The results showed that high absolute humidity (measured by vapor pressure) was significantly (p < 0.05) associated with increased risks of all-cause and cardiorespiratory deaths, but not with increased risks of pneumonia and influenza deaths. The association between absolute humidity and mortality risks was found consistent among the two cities. An increasing pattern of influenza associated mortality risks was also found across the strata of low to high relative humidity, but the results were less consistent for temperature.Conclusions: These findings highlight the need for people with chronic cardiovascular and respiratory diseases to take extra caution against influenza during hot and humid days in the subtropics and tropics. © 2011 Yang et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/145907
ISSN
2015 Impact Factor: 2.69
2015 SCImago Journal Rankings: 1.510
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence Scheme of the University Grants Committee of the Hong Kong Special Administrative RegionAoE/M-12/06
Research Fund for the Control of Infectious Diseases/Health
Health Services Research Fund04050212
University Grants Committee of the Hong Kong Special Administrative RegionAoE/M-12/06
Funding Information:

We thank Peter Chapman for making the map and proofreading the manuscript. This study was supported by the Research Fund for the Control of Infectious Diseases/Health and Health Services Research Fund [04050212]; and the Area of Excellence Scheme of the University Grants Committee of the Hong Kong Special Administrative Region [AoE/M-12/06].

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYang, Len_HK
dc.contributor.authorChen, PYen_HK
dc.contributor.authorHe, JFen_HK
dc.contributor.authorChan, KPen_HK
dc.contributor.authorOu, CQen_HK
dc.contributor.authorDeng, APen_HK
dc.contributor.authorMalik Peiris, JSen_HK
dc.contributor.authorWong, CMen_HK
dc.date.accessioned2012-03-27T09:01:39Z-
dc.date.available2012-03-27T09:01:39Z-
dc.date.issued2011en_HK
dc.identifier.citationBmc Infectious Diseases, 2011, v. 11en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145907-
dc.description.abstractBackground: Environmental factors have been associated with transmission and survival of influenza viruses but no studies have ever explored the role of environmental factors on severity of influenza infection.Methods: We applied a Poisson regression model to the mortality data of two Chinese metropolitan cities located within the subtropical zone, to calculate the influenza associated excess mortality risks during the periods with different levels of temperature and humidity.Results: The results showed that high absolute humidity (measured by vapor pressure) was significantly (p < 0.05) associated with increased risks of all-cause and cardiorespiratory deaths, but not with increased risks of pneumonia and influenza deaths. The association between absolute humidity and mortality risks was found consistent among the two cities. An increasing pattern of influenza associated mortality risks was also found across the strata of low to high relative humidity, but the results were less consistent for temperature.Conclusions: These findings highlight the need for people with chronic cardiovascular and respiratory diseases to take extra caution against influenza during hot and humid days in the subtropics and tropics. © 2011 Yang et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsBMC Infectious Diseases. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshClimate-
dc.subject.meshHumidity-
dc.subject.meshInfluenza, Human - mortality-
dc.subject.meshSurvival Analysis-
dc.subject.meshTemperature-
dc.titleEffect modification of environmental factors on influenza-associated mortality: a time-series study in two Chinese citiesen_HK
dc.typeArticleen_HK
dc.identifier.emailMalik Peiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailWong, CM: hrmrwcm@hku.hken_HK
dc.identifier.authorityMalik Peiris, JS=rp00410en_HK
dc.identifier.authorityWong, CM=rp00338en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2334-11-342en_HK
dc.identifier.pmid22168284-
dc.identifier.pmcidPMC3265445-
dc.identifier.scopuseid_2-s2.0-83355172214en_HK
dc.identifier.hkuros198827en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83355172214&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.isiWOS:000300064300001-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectEstimation of the effect of influenza on cardiorespiratory and all causes mortality in tropical and sub-tropical climates - a comparative study between Hong Kong, Singapore and Guangzhou for influence of seasonality and meteorological conditions-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridYang, L=7406279703en_HK
dc.identifier.scopusauthoridChen, PY=16303279100en_HK
dc.identifier.scopusauthoridHe, JF=25926440500en_HK
dc.identifier.scopusauthoridChan, KP=54921825100en_HK
dc.identifier.scopusauthoridOu, CQ=36880461400en_HK
dc.identifier.scopusauthoridDeng, AP=55138223300en_HK
dc.identifier.scopusauthoridMalik Peiris, JS=7005486823en_HK
dc.identifier.scopusauthoridWong, CM=7404954904en_HK
dc.identifier.citeulike10130014-

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