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Article: Single-centre experience of liver transplantation for familial amyloidotic polyneuropathy of non-Val30Met variants in Chinese patients

TitleSingle-centre experience of liver transplantation for familial amyloidotic polyneuropathy of non-Val30Met variants in Chinese patients
Authors
KeywordsDomino liver transplant
Hepatocellular carcinoma
Living donor liver transplant
Transthyretin
Val30Ala
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13506129.asp
Citation
Amyloid, 2012, v. 19 n. 1, p. 33-36 How to Cite?
AbstractOBJECTIVE: To review our experience of liver transplantation (LT) for patients with non-Val30Met familial amyloidotic polyneuropathy (FAP) and patients receiving FAP livers. METHOD: Data of six FAP patients and five FAP liver recipients, all Chinese, were reviewed. RESULTS: Among the six FAP patients, five patients were of the V30A variant and one patient was of the G67E variant. One patient had malnutrition. Three patients had peripheral neuropathy. Four patients had orthostatic hypotension. Five patients had cardiac involvement. Two patients underwent living-donor LT and four patients underwent deceased-donor LT. One patient had progressive cardiac and neurological involvement after transplantation. Three patients showed either improvement or a static condition. All five FAP liver recipients had hepatitis-B-related hepatocellular carcinoma before transplantation. With a median follow-up period of 49 months, all of them survived without tumour recurrence. The first recipient developed systemic transthyretin amyloidosis six years after transplantation. Upper endoscopy confirmed the presence of gastric amyloidosis, and nerve conduction test showed evidence of axonal sensorimotor polyneuropathy. CONCLUSIONS: Most of the FAP patients and FAP liver recipients displayed satisfactory outcomes after transplantation. LT halted disease progression in the FAP patients who had early presentation of the disease. © 2012 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/145901
ISSN
2015 Impact Factor: 2.351
2015 SCImago Journal Rankings: 1.160
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDai, WCen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorCheung, TTen_HK
dc.contributor.authorSharr, WWen_HK
dc.contributor.authorChan, ACYen_HK
dc.contributor.authorFung, JYYen_HK
dc.contributor.authorTsang, SHYen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLo, CMen_HK
dc.date.accessioned2012-03-27T09:01:24Z-
dc.date.available2012-03-27T09:01:24Z-
dc.date.issued2012en_HK
dc.identifier.citationAmyloid, 2012, v. 19 n. 1, p. 33-36en_HK
dc.identifier.issn1350-6129en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145901-
dc.description.abstractOBJECTIVE: To review our experience of liver transplantation (LT) for patients with non-Val30Met familial amyloidotic polyneuropathy (FAP) and patients receiving FAP livers. METHOD: Data of six FAP patients and five FAP liver recipients, all Chinese, were reviewed. RESULTS: Among the six FAP patients, five patients were of the V30A variant and one patient was of the G67E variant. One patient had malnutrition. Three patients had peripheral neuropathy. Four patients had orthostatic hypotension. Five patients had cardiac involvement. Two patients underwent living-donor LT and four patients underwent deceased-donor LT. One patient had progressive cardiac and neurological involvement after transplantation. Three patients showed either improvement or a static condition. All five FAP liver recipients had hepatitis-B-related hepatocellular carcinoma before transplantation. With a median follow-up period of 49 months, all of them survived without tumour recurrence. The first recipient developed systemic transthyretin amyloidosis six years after transplantation. Upper endoscopy confirmed the presence of gastric amyloidosis, and nerve conduction test showed evidence of axonal sensorimotor polyneuropathy. CONCLUSIONS: Most of the FAP patients and FAP liver recipients displayed satisfactory outcomes after transplantation. LT halted disease progression in the FAP patients who had early presentation of the disease. © 2012 Informa UK, Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13506129.aspen_HK
dc.relation.ispartofAmyloiden_HK
dc.rightsAmyloid. Copyright © Informa Healthcare.-
dc.subjectDomino liver transplanten_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectLiving donor liver transplanten_HK
dc.subjectTransthyretinen_HK
dc.subjectVal30Alaen_HK
dc.titleSingle-centre experience of liver transplantation for familial amyloidotic polyneuropathy of non-Val30Met variants in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, SC: chanlsc@hku.hken_HK
dc.identifier.emailChok, KSH: kennethchok@yahoo.com.hken_HK
dc.identifier.emailCheung, TT: cheung68@hku.hken_HK
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityChan, ACY=rp00310en_HK
dc.identifier.authorityFung, JYY=rp00518en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/13506129.2012.655867en_HK
dc.identifier.pmid22320251-
dc.identifier.scopuseid_2-s2.0-84857230483en_HK
dc.identifier.hkuros198961en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857230483&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue1en_HK
dc.identifier.spage33en_HK
dc.identifier.epage36en_HK
dc.identifier.isiWOS:000300434500006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridTsang, SHY=7102255986en_HK
dc.identifier.scopusauthoridFung, JYY=55003370300en_HK
dc.identifier.scopusauthoridChan, ACY=15828849100en_HK
dc.identifier.scopusauthoridSharr, WW=36864499000en_HK
dc.identifier.scopusauthoridCheung, TT=7103334165en_HK
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK
dc.identifier.scopusauthoridChan, SC=36901164300en_HK
dc.identifier.scopusauthoridDai, WC=36186690700en_HK

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