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Article: Risk factors for osteoradionecrosis after head and neck radiation: a systematic review

TitleRisk factors for osteoradionecrosis after head and neck radiation: a systematic review
Authors
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.oooojournal.net
Citation
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2012, v. 113 n. 1, p. 54-69 How to Cite?
AbstractOBJECTIVE: This systematic review aimed to answer the clinical question, 'What is the current risk of developing osteoradionecrosis of the jaws among irradiated head and neck cancer patients?' STUDY DESIGN: A systematic review of published English-language randomized controlled trials on the outcome of radiation therapy was performed via Medline and Embase databases. Data on osteoradionecrosis/bone toxicity were collected and analyzed. RESULTS: Twenty-two articles reporting on a total of 5,742 patients were selected for final review based on strict eligibility criteria. An estimated 2% of the head and neck-irradiated patients are at risk of developing osteoradionecrosis. Patients receiving adjunctive radiotherapy, accelerated fractionation without dose reduction, and chemoradiotherapy show no increase in osteoradionecrosis risk. Accelerated fractionation with dose reduction is associated with a reduced risk, whereas hyperfractionation shows elevated risk of developing osteoradionecrosis. CONCLUSIONS: The risk of developing osteoradionecrosis among the irradiated head and neck cancer patient has significantly declined in recent years.
Persistent Identifierhttp://hdl.handle.net/10722/145863
ISSN
2015 Impact Factor: 1.262
2015 SCImago Journal Rankings: 0.666
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNabil, Sen_US
dc.contributor.authorSamman, Nen_US
dc.date.accessioned2012-03-27T07:59:53Z-
dc.date.available2012-03-27T07:59:53Z-
dc.date.issued2012en_US
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2012, v. 113 n. 1, p. 54-69en_US
dc.identifier.issn2212-4403-
dc.identifier.urihttp://hdl.handle.net/10722/145863-
dc.description.abstractOBJECTIVE: This systematic review aimed to answer the clinical question, 'What is the current risk of developing osteoradionecrosis of the jaws among irradiated head and neck cancer patients?' STUDY DESIGN: A systematic review of published English-language randomized controlled trials on the outcome of radiation therapy was performed via Medline and Embase databases. Data on osteoradionecrosis/bone toxicity were collected and analyzed. RESULTS: Twenty-two articles reporting on a total of 5,742 patients were selected for final review based on strict eligibility criteria. An estimated 2% of the head and neck-irradiated patients are at risk of developing osteoradionecrosis. Patients receiving adjunctive radiotherapy, accelerated fractionation without dose reduction, and chemoradiotherapy show no increase in osteoradionecrosis risk. Accelerated fractionation with dose reduction is associated with a reduced risk, whereas hyperfractionation shows elevated risk of developing osteoradionecrosis. CONCLUSIONS: The risk of developing osteoradionecrosis among the irradiated head and neck cancer patient has significantly declined in recent years.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.oooojournal.net-
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyen_US
dc.titleRisk factors for osteoradionecrosis after head and neck radiation: a systematic reviewen_US
dc.typeArticleen_US
dc.identifier.emailSamman, N: nsamman@hkucc.hku.hken_US
dc.identifier.authoritySamman, N=rp00021en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tripleo.2011.07.042-
dc.identifier.pmid22669065-
dc.identifier.scopuseid_2-s2.0-84862569028-
dc.identifier.hkuros199044en_US
dc.identifier.volume113en_US
dc.identifier.issue1en_US
dc.identifier.spage54en_US
dc.identifier.epage69en_US
dc.identifier.eissn1528-395X-
dc.identifier.isiWOS:000300781900008-
dc.publisher.placeUnited States-

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