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Article: Microbial chemical signaling: a current perspective

TitleMicrobial chemical signaling: a current perspective
Authors
KeywordsAutoinducer
Bacteria
Cell-cell signaling
Fungi
Quorum sensing
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1040841x.asp
Citation
Critical Reviews in Microbiology, 2012, v. 38 n. 3, p. 217-249 How to Cite?
AbstractCommunication among microorganisms is mediated through quorum sensing. The latter is defined as cell-density linked, coordinated gene expression in microbial populations as a response to threshold signal concentrations followed by induction of a synchronized population response. This phenomenon is used by a variety of microbes to optimize their survival in a constantly challenging, dynamic milieu, by correlating individual cellular functions to community-based requirements. The synthesis, secretion, and perception of quorum-sensing molecules and their target response play a pivotal role in quorum sensing and are tightly controlled by complex, multilayered and interconnected signal transduction pathways that regulate diverse cellular functions. Quorum sensing exemplifies interactive social behavior innate to the microbial world that controls features such as, virulence, biofilm maturation, antibiotic resistance, swarming motility, and conjugal plasmid transfer. Over the past two decades, studies have been performed to rationalize bacterial cell-to-cell communication mediated by structurally and functionally diverse small molecules. This review describes the theoretical aspects of cellular and quorum-sensing mechanisms that affect microbial physiology and pathobiology. © 2012 Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/145861
ISSN
2015 Impact Factor: 8.192
2015 SCImago Journal Rankings: 1.970
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBandara, HMHNen_US
dc.contributor.authorLam, OLTen_US
dc.contributor.authorJin, LJen_US
dc.contributor.authorSamaranayake, Len_US
dc.date.accessioned2012-03-27T07:59:53Z-
dc.date.available2012-03-27T07:59:53Z-
dc.date.issued2012en_US
dc.identifier.citationCritical Reviews in Microbiology, 2012, v. 38 n. 3, p. 217-249en_US
dc.identifier.issn1040-841X-
dc.identifier.urihttp://hdl.handle.net/10722/145861-
dc.description.abstractCommunication among microorganisms is mediated through quorum sensing. The latter is defined as cell-density linked, coordinated gene expression in microbial populations as a response to threshold signal concentrations followed by induction of a synchronized population response. This phenomenon is used by a variety of microbes to optimize their survival in a constantly challenging, dynamic milieu, by correlating individual cellular functions to community-based requirements. The synthesis, secretion, and perception of quorum-sensing molecules and their target response play a pivotal role in quorum sensing and are tightly controlled by complex, multilayered and interconnected signal transduction pathways that regulate diverse cellular functions. Quorum sensing exemplifies interactive social behavior innate to the microbial world that controls features such as, virulence, biofilm maturation, antibiotic resistance, swarming motility, and conjugal plasmid transfer. Over the past two decades, studies have been performed to rationalize bacterial cell-to-cell communication mediated by structurally and functionally diverse small molecules. This review describes the theoretical aspects of cellular and quorum-sensing mechanisms that affect microbial physiology and pathobiology. © 2012 Informa Healthcare USA, Inc.-
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1040841x.asp-
dc.relation.ispartofCritical Reviews in Microbiologyen_US
dc.rightsCritical Reviews in Microbiology. Copyright © Informa Healthcare.-
dc.subjectAutoinducer-
dc.subjectBacteria-
dc.subjectCell-cell signaling-
dc.subjectFungi-
dc.subjectQuorum sensing-
dc.subject.meshAdaptation, Physiological-
dc.subject.meshBacterial physiological phenomena-
dc.subject.meshFungi - physiology-
dc.subject.meshHumans-
dc.subject.meshQuorum sensing-
dc.subject.meshGene expression regulation, Fungal-
dc.subject.meshGene expression regulation, Bacterial-
dc.subject.meshSignal transduction-
dc.titleMicrobial chemical signaling: a current perspectiveen_US
dc.typeArticleen_US
dc.identifier.emailLam, OLT: ottolam@hku.hken_US
dc.identifier.emailJin, LJ: ljjin@hkucc.hku.hken_US
dc.identifier.emailSamaranayake, L: lakshman@hku.hken_US
dc.identifier.authorityLam, OLT=rp01567en_US
dc.identifier.authorityJin, LJ=rp00028en_US
dc.identifier.authoritySamaranayake, L=rp00023en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/1040841X.2011.652065-
dc.identifier.pmid22300377-
dc.identifier.scopuseid_2-s2.0-84863493826-
dc.identifier.hkuros199013en_US
dc.identifier.volume38-
dc.identifier.issue3-
dc.identifier.spage217en_US
dc.identifier.epage249en_US
dc.identifier.isiWOS:000305963000005-
dc.publisher.placeUnited Kingdom-

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