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Article: Healing outcomes at implants installed in grafted sites: an experimental study in dogs

TitleHealing outcomes at implants installed in grafted sites: an experimental study in dogs
Authors
Issue Date2012
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2012, v. 23 n. 3, p. 340-350 How to Cite?
AbstractAIM: To evaluate the integration of implants installed using a surgical guide in augmented sites with autologous bone or deproteinized bovine bone mineral (DBBM) blocks, concomitantly with a collagen membrane. MATERIAL AND METHODS: Mandibular molars were extracted bilaterally in six Labrador dogs, the buccal bony wall was removed, and a box-shaped defect was created. After 3 months, flaps were elevated, a bony graft was harvested from the ascending ramus, and secured to the lateral wall of the defect by means of screws. In the left mandibular side, a DBBM block was fixed into the defect. A resorbable membrane was applied at both sides, and the flaps were sutured. After 3 months, flaps were elevated, and a customized device was used as surgical guide to prepare the recipient sites in the interface between grafts and parent bone. One implant was installed in each side of the mandible. After 3 months, biopsies were harvested, and ground sections were prepared for histologic evaluation. RESULTS: One autologous bone block graft was lost before implant installation. The width of the alveolar crest at the test sites (DBBM) was 5.4 +/- 1.2 mm before, 9.4 +/- 1.2 mm immediately after grafting, and 9.3 +/- 1 mm at implant installation. At the control sites (autologous bone), the corresponding values were: 5.2 +/- 1, 9 +/- 1.2, and 8.7 +/- 0.9 mm, respectively. All implants installed were available for histologic evaluation (n = 5). The autologous bone grafts, rich in vessels and cells, were integrated in the parent bone, and only little non-vital bone was found. The BIC% was 56.7 +/- 15.6% and 54.2 +/- 13.2% at the buccal and lingual aspects, respectively. At the test sites, the DBBM appeared to be embedded into connective tissue, and very little newly formed bone was encountered within the grafts. The BIC% was 5.8 +/- 12.3% and 51.3 +/- 14.2% at the buccal and lingual aspects, respectively. CONCLUSIONS: Autologous bone blocks used to augment the alveolar bony crest horizontally allowed the complete osseointegration of implants installed after 3 months of healing. However, similar blocks of DBBM did not promote osseointegration, although the installed implants were stable owing to the osseointegration in the sites of the parent bone.
Persistent Identifierhttp://hdl.handle.net/10722/145856
ISSN
2015 Impact Factor: 3.464
2015 SCImago Journal Rankings: 1.427
ISI Accession Number ID
Funding AgencyGrant Number
Sweden Martina SRL
Due Carrare
Padova, Italy
ARDEC
Ariminum Odontologica SRL
Rimini, Italy
Funding Information:

This study has been supported by a grant from Sweden & Martina SRL, Due Carrare, Padova, Italy, and by ARDEC, Ariminum Odontologica SRL, Rimini, Italy. Moreover, the manufacturing of the installation devices by Engineer Enrico Babetto of Sweden & Martina SRL is highly appreciated. The material for the regenerative procedures was kindly provided by Geistlich Biomaterials, Wolhusen, LU, Switzerland. The competent contributions of Mr. Sebastiao Bianco (USP - Faculty of Dentistry of Ribeirao Preto - University of Sao Paulo, Sao Paulo, Brazil) in the histologic processing are highly acknowledged. All the authors declare to have no conflict of interest with the materials used in the present study.

 

DC FieldValueLanguage
dc.contributor.authorDe Santis, Een_US
dc.contributor.authorLang, NPen_US
dc.contributor.authorScala, Aen_US
dc.contributor.authorViganĂ², Pen_US
dc.contributor.authorSalata, LAen_US
dc.contributor.authorBotticelli, Den_US
dc.date.accessioned2012-03-27T07:59:51Z-
dc.date.available2012-03-27T07:59:51Z-
dc.date.issued2012en_US
dc.identifier.citationClinical Oral Implants Research, 2012, v. 23 n. 3, p. 340-350en_US
dc.identifier.issn0905-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/145856-
dc.description.abstractAIM: To evaluate the integration of implants installed using a surgical guide in augmented sites with autologous bone or deproteinized bovine bone mineral (DBBM) blocks, concomitantly with a collagen membrane. MATERIAL AND METHODS: Mandibular molars were extracted bilaterally in six Labrador dogs, the buccal bony wall was removed, and a box-shaped defect was created. After 3 months, flaps were elevated, a bony graft was harvested from the ascending ramus, and secured to the lateral wall of the defect by means of screws. In the left mandibular side, a DBBM block was fixed into the defect. A resorbable membrane was applied at both sides, and the flaps were sutured. After 3 months, flaps were elevated, and a customized device was used as surgical guide to prepare the recipient sites in the interface between grafts and parent bone. One implant was installed in each side of the mandible. After 3 months, biopsies were harvested, and ground sections were prepared for histologic evaluation. RESULTS: One autologous bone block graft was lost before implant installation. The width of the alveolar crest at the test sites (DBBM) was 5.4 +/- 1.2 mm before, 9.4 +/- 1.2 mm immediately after grafting, and 9.3 +/- 1 mm at implant installation. At the control sites (autologous bone), the corresponding values were: 5.2 +/- 1, 9 +/- 1.2, and 8.7 +/- 0.9 mm, respectively. All implants installed were available for histologic evaluation (n = 5). The autologous bone grafts, rich in vessels and cells, were integrated in the parent bone, and only little non-vital bone was found. The BIC% was 56.7 +/- 15.6% and 54.2 +/- 13.2% at the buccal and lingual aspects, respectively. At the test sites, the DBBM appeared to be embedded into connective tissue, and very little newly formed bone was encountered within the grafts. The BIC% was 5.8 +/- 12.3% and 51.3 +/- 14.2% at the buccal and lingual aspects, respectively. CONCLUSIONS: Autologous bone blocks used to augment the alveolar bony crest horizontally allowed the complete osseointegration of implants installed after 3 months of healing. However, similar blocks of DBBM did not promote osseointegration, although the installed implants were stable owing to the osseointegration in the sites of the parent bone.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_US
dc.relation.ispartofClinical Oral Implants Researchen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.comen_US
dc.subject.meshAlveolar Ridge Augmentation - methods-
dc.subject.meshBone Transplantation - methods-
dc.subject.meshDental Implantation, Endosseous - methods-
dc.subject.meshDental Implants-
dc.subject.meshWound Healing - physiology-
dc.titleHealing outcomes at implants installed in grafted sites: an experimental study in dogsen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0905-7161&volume=23&issue=3&spage=340&epage=350&date=2012&atitle=Healing+outcomes+at+implants+installed+in+grafted+sites:+an+experimental+study+in+dogsen_US
dc.identifier.emailLang, NP: nplang@hkucc.hku.hken_US
dc.identifier.emailBotticelli, D: daniele.botticelli@ardec.it-
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0501.2011.02326.x-
dc.identifier.pmid22092302-
dc.identifier.scopuseid_2-s2.0-84856910624-
dc.identifier.hkuros198885en_US
dc.identifier.volume23en_US
dc.identifier.issue3en_US
dc.identifier.spage340en_US
dc.identifier.epage350en_US
dc.identifier.isiWOS:000300503800011-
dc.publisher.placeUnited States-

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