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Article: From understanding synaptic plasticity to the development of cognitive enhancers

TitleFrom understanding synaptic plasticity to the development of cognitive enhancers
Authors
KeywordsAlzheimer's disease
BDNF
dendritic spines
depression
synaptic plasticity
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNP
Citation
International Journal Of Neuropsychopharmacology, 2011, v. 14 n. 9, p. 1247-1256 How to Cite?
AbstractAccumulating evidence reveals that synaptic dysfunction precedes neuronal loss in neurodegenerative diseases such as Alzheimer's disease. Intriguingly, synaptic abnormality is also implicated in a myriad of psychiatric disorders including depression. In particular, alterations in spine density and morphology have been associated with aberrant synaptic activity in these diseased brains. Understanding the molecular mechanisms underlying the regulation of spine morphogenesis, synaptic function and plasticity under physiological and pathological conditions will therefore provide critical insights for the development of potential therapeutic agents against these diseases. Here we summarize existing knowledge on some of the molecular players in synaptic plasticity, and highlight how these findings from basic neuroscientific research aid in the identification of novel drug leads for the development of therapeutics. © 2011 CINP.
Persistent Identifierhttp://hdl.handle.net/10722/145832
ISSN
2015 Impact Factor: 4.333
2015 SCImago Journal Rankings: 1.690
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong6431/06M
661109
661309
1/06C
Area of Excellence Scheme of the University Grants CommitteeAoE/B-15/01
Hong Kong Jockey Club
Funding Information:

We thank Ka-Chun Lok for his excellent help in preparing the figures and Dr Amy Fu for critical reading of the manuscript. The study of N. Y. Ip and Z. H. Cheung was supported in part by the Research Grants Council of Hong Kong (HKUST 6431/06M, 661109, 661309 and 1/06C) and the Area of Excellence Scheme of the University Grants Committee (AoE/B-15/01) and the Hong Kong Jockey Club. N. Y. lp and Z. H. Cheung were Croucher Foundation Senior Research Fellow and Croucher Foundation Fellow, respectively.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:54Z-
dc.date.available2012-03-23T09:49:54Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Neuropsychopharmacology, 2011, v. 14 n. 9, p. 1247-1256en_HK
dc.identifier.issn1461-1457en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145832-
dc.description.abstractAccumulating evidence reveals that synaptic dysfunction precedes neuronal loss in neurodegenerative diseases such as Alzheimer's disease. Intriguingly, synaptic abnormality is also implicated in a myriad of psychiatric disorders including depression. In particular, alterations in spine density and morphology have been associated with aberrant synaptic activity in these diseased brains. Understanding the molecular mechanisms underlying the regulation of spine morphogenesis, synaptic function and plasticity under physiological and pathological conditions will therefore provide critical insights for the development of potential therapeutic agents against these diseases. Here we summarize existing knowledge on some of the molecular players in synaptic plasticity, and highlight how these findings from basic neuroscientific research aid in the identification of novel drug leads for the development of therapeutics. © 2011 CINP.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNPen_HK
dc.relation.ispartofInternational Journal of Neuropsychopharmacologyen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectBDNFen_HK
dc.subjectdendritic spinesen_HK
dc.subjectdepressionen_HK
dc.subjectsynaptic plasticityen_HK
dc.titleFrom understanding synaptic plasticity to the development of cognitive enhancersen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S1461145710001537en_HK
dc.identifier.scopuseid_2-s2.0-84856069899en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856069899&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1247en_HK
dc.identifier.epage1256en_HK
dc.identifier.eissn1469-5111-
dc.identifier.isiWOS:000295434600009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridIp, NY=35318021000en_HK

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