File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Molecular machinery of macroautophagy and its deregulation in diseases

TitleMolecular machinery of macroautophagy and its deregulation in diseases
Authors
KeywordsSpecies Index: Mammalia
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis
Citation
Biochimica Et Biophysica Acta - Molecular Basis Of Disease, 2011, v. 1812 n. 11, p. 1490-1497 How to Cite?
AbstractMacroautophagy maintains cellular homeostasis through targeting cytoplasmic contents and organelles into autophagosomes for degradation. This process begins with the assembly of protein complexes on isolation membrane to initiate the formation of autophagosome, followed by its nucleation, elongation and maturation. Fusion of autophagosomes with lysosomes then leads to degradation of the cargo. In the past decade, significant advances have been made on the identification of molecular players that are implicated in various stages of macroautophagy. Post-translational modifications of macroautophagy regulators have also been demonstrated to be critical for the selective targeting of cytoplasmic contents into autophagosomes. In addition, recent demonstration of distinct macroautophagy regulators has led to the identification of different subtypes of macroautophagy. Since deregulation of macroautophagy is implicated in diseases including neurodegenerative disorders, cancers and inflammatory disorders, understanding the molecular machinery of macroautophagy is crucial for elucidating the mechanisms by which macroautophagy is deregulated in these diseases, thereby revealing new potential therapeutic targets and strategies. Here we summarize current knowledge on the regulation of mammalian macroautophagy machineries and their disease-associated deregulation. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/145831
ISSN
2015 Impact Factor: 5.158
2015 SCImago Journal Rankings: 2.718
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKUST 661007
661109
660309
660210
6/CRF/08
University Grants CommitteeAoE/B-15/01
Hong Kong Jockey Club
Croucher Foundation
Funding Information:

We apologize to authors whose work could not be discussed or cited due to space limitations. This work was supported in part by the Research Grants Council of Hong Kong (HKUST 661007, 661109, 660309, 660210, and 6/CRF/08), the Area of Excellence Scheme of the University Grants Committee (AoE/B-15/01) and the Hong Kong Jockey Club. N.Y.I. and Z.H.C were recipients of the Croucher Foundation Senior Research Fellow and Croucher Foundation Fellow respectively.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, ASLen_HK
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:53Z-
dc.date.available2012-03-23T09:49:53Z-
dc.date.issued2011en_HK
dc.identifier.citationBiochimica Et Biophysica Acta - Molecular Basis Of Disease, 2011, v. 1812 n. 11, p. 1490-1497en_HK
dc.identifier.issn0925-4439en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145831-
dc.description.abstractMacroautophagy maintains cellular homeostasis through targeting cytoplasmic contents and organelles into autophagosomes for degradation. This process begins with the assembly of protein complexes on isolation membrane to initiate the formation of autophagosome, followed by its nucleation, elongation and maturation. Fusion of autophagosomes with lysosomes then leads to degradation of the cargo. In the past decade, significant advances have been made on the identification of molecular players that are implicated in various stages of macroautophagy. Post-translational modifications of macroautophagy regulators have also been demonstrated to be critical for the selective targeting of cytoplasmic contents into autophagosomes. In addition, recent demonstration of distinct macroautophagy regulators has led to the identification of different subtypes of macroautophagy. Since deregulation of macroautophagy is implicated in diseases including neurodegenerative disorders, cancers and inflammatory disorders, understanding the molecular machinery of macroautophagy is crucial for elucidating the mechanisms by which macroautophagy is deregulated in these diseases, thereby revealing new potential therapeutic targets and strategies. Here we summarize current knowledge on the regulation of mammalian macroautophagy machineries and their disease-associated deregulation. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadisen_HK
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Diseaseen_HK
dc.subjectSpecies Index: Mammaliaen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshAutophagyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInflammation - physiopathologyen_HK
dc.subject.meshNeoplasms - physiopathologyen_HK
dc.subject.meshNeurodegenerative Diseases - physiopathologyen_HK
dc.titleMolecular machinery of macroautophagy and its deregulation in diseasesen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbadis.2011.07.005en_HK
dc.identifier.pmid21787863-
dc.identifier.scopuseid_2-s2.0-80053438277en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053438277&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1812en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1490en_HK
dc.identifier.epage1497en_HK
dc.identifier.eissn1879-260X-
dc.identifier.isiWOS:000296952600016-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, ASL=37102817200en_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridIp, NY=35899235100en_HK
dc.identifier.citeulike9625922-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats