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Article: Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases

TitleSynaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases
Authors
KeywordsChemicals And Cas Registry Numbers: Cyclin-Dependent Kinase 5, Ec 2.7.1.37
Receptors, Neurotransmitter
Issue Date2006
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron
Citation
Neuron, 2006, v. 50 n. 1, p. 13-18 How to Cite?
AbstractAccumulating evidence indicates that cyclin dependent kinase 5 (Cdk5), through phosphorylating a plethora of pre- and postsynaptic proteins, functions as an essential modulator of synaptic transmission. Recent advances in the field of Cdk5 research have not only consolidated the in vivo importance of Cdk5 in neurotransmission but also suggest a pivotal role of Cdk5 in the regulation of higher cognitive functions and neurodegenerative diseases. In this review, we will discuss the recent findings on the emanating role of Cdk5 as a regulator of synaptic functions and plasticity. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/145824
ISSN
2015 Impact Factor: 13.974
2015 SCImago Journal Rankings: 11.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorFu, AKYen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:50Z-
dc.date.available2012-03-23T09:49:50Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuron, 2006, v. 50 n. 1, p. 13-18en_HK
dc.identifier.issn0896-6273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145824-
dc.description.abstractAccumulating evidence indicates that cyclin dependent kinase 5 (Cdk5), through phosphorylating a plethora of pre- and postsynaptic proteins, functions as an essential modulator of synaptic transmission. Recent advances in the field of Cdk5 research have not only consolidated the in vivo importance of Cdk5 in neurotransmission but also suggest a pivotal role of Cdk5 in the regulation of higher cognitive functions and neurodegenerative diseases. In this review, we will discuss the recent findings on the emanating role of Cdk5 as a regulator of synaptic functions and plasticity. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuronen_HK
dc.relation.ispartofNeuronen_HK
dc.subjectChemicals And Cas Registry Numbers: Cyclin-Dependent Kinase 5, Ec 2.7.1.37en_US
dc.subjectReceptors, Neurotransmitteren_US
dc.subject.meshAnimalsen_HK
dc.subject.meshCognition - physiologyen_HK
dc.subject.meshCyclin-Dependent Kinase 5 - metabolismen_HK
dc.subject.meshGene Expression Regulation - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshModels, Neurologicalen_HK
dc.subject.meshNeurodegenerative Diseases - metabolismen_HK
dc.subject.meshReceptors, Neurotransmitter - metabolismen_HK
dc.subject.meshSignal Transduction - physiologyen_HK
dc.subject.meshSynapses - metabolismen_HK
dc.subject.meshSynaptic Transmission - physiologyen_HK
dc.titleSynaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseasesen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuron.2006.02.024en_HK
dc.identifier.pmid16600851-
dc.identifier.scopuseid_2-s2.0-33645962807en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645962807&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage18en_HK
dc.identifier.isiWOS:000236811300006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridFu, AKY=7005549599en_HK
dc.identifier.scopusauthoridIp, NY=7005756760en_HK

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