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Article: The roles of cyclin-dependent kinase 5 in dendtrite and synapse development

TitleThe roles of cyclin-dependent kinase 5 in dendtrite and synapse development
Authors
KeywordsChemicals And Cas Registry Numbers: Neurotropin, 57657-35-9
Semaphorin 3A, 167821-03-6, 516536-20-2
Cdk5 Protein, Human, 2.7.1.37
Cyclin-Dependent Kinase 5, 2.7.1.37
Nerve Tissue Proteins
Issue Date2007
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.biotechnology-journal.com
Citation
Biotechnology Journal, 2007, v. 2 n. 8, p. 949-957 How to Cite?
AbstractSince the isolation of cyclin-dependent kinase 5 (Cdk5), this proline-directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Recently, a number of players implicated in dendrite and synapse development have been identified as Cdk5 substrates. Neurite extension, synapse and spine maturation are all modulated by a myriad of extracellular guidance cues or trophic factors. Cdk5 was recently demonstrated to regulate signaling downstream of some of these extracellular factors, in addition to modulating Rho GTPase activity, which regulates cytoskeletal dynamics. In this communication, we summarize our existing knowledge on the pathways and mechanisms through which Cdk5 affects dendrite, synapse and spine development. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/145819
ISSN
2015 Impact Factor: 3.781
2015 SCImago Journal Rankings: 1.185
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:48Z-
dc.date.available2012-03-23T09:49:48Z-
dc.date.issued2007en_HK
dc.identifier.citationBiotechnology Journal, 2007, v. 2 n. 8, p. 949-957en_HK
dc.identifier.issn1860-6768en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145819-
dc.description.abstractSince the isolation of cyclin-dependent kinase 5 (Cdk5), this proline-directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Recently, a number of players implicated in dendrite and synapse development have been identified as Cdk5 substrates. Neurite extension, synapse and spine maturation are all modulated by a myriad of extracellular guidance cues or trophic factors. Cdk5 was recently demonstrated to regulate signaling downstream of some of these extracellular factors, in addition to modulating Rho GTPase activity, which regulates cytoskeletal dynamics. In this communication, we summarize our existing knowledge on the pathways and mechanisms through which Cdk5 affects dendrite, synapse and spine development. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.biotechnology-journal.comen_HK
dc.relation.ispartofBiotechnology Journalen_HK
dc.subjectChemicals And Cas Registry Numbers: Neurotropin, 57657-35-9en_US
dc.subjectSemaphorin 3A, 167821-03-6, 516536-20-2en_US
dc.subjectCdk5 Protein, Human, 2.7.1.37en_US
dc.subjectCyclin-Dependent Kinase 5, 2.7.1.37en_US
dc.subjectNerve Tissue Proteinsen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - enzymologyen_HK
dc.subject.meshCell Enlargementen_HK
dc.subject.meshCyclin-Dependent Kinase 5 - metabolismen_HK
dc.subject.meshDendrites - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNerve Tissue Proteins - metabolismen_HK
dc.subject.meshPhosphorylationen_HK
dc.subject.meshSynapses - physiologyen_HK
dc.titleThe roles of cyclin-dependent kinase 5 in dendtrite and synapse developmenten_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_HK
dc.identifier.authorityCheung, ZH=rp01588en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/biot.200700056en_HK
dc.identifier.pmid17526057-
dc.identifier.scopuseid_2-s2.0-34548496016en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548496016&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue8en_HK
dc.identifier.spage949en_HK
dc.identifier.epage957en_HK
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridCheung, ZH=6507483375en_HK
dc.identifier.scopusauthoridIp, NY=7005756760en_HK

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