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Article: Endophilin B1. Guarding the gate to destruction

TitleEndophilin B1. Guarding the gate to destruction
Authors
Issue Date2009
Citation
Communicative And Integrative Biology, 2009, v. 2 n. 2, p. 130-132 How to Cite?
AbstractEndophilin B1 is a member of the endophilin family that is localized predominantly to intracellular membranes. Also known as Bax-interacting factor-1 (Bif-1), this protein has been observed to regulate the membrane dynamics of various intracellular compartments, such as the control of mitochondrial morphology and autophagosome formation in fibroblast. Endophilin B1 is expressed in the brain, but its functions in neurons had remained unknown. Recently, we have observed a novel role of endophilin B1 in neurons where it controls the trafficking of TrkA, cognate receptor for the prototypic neurotrophin nerve growth factor (NGF). Knock-down of endophilin B1 expression induces precocious targeting of NGF/TrkA to late endosomes and lysosomes, thereby leading to reduced TrkA levels. This is accompanied by marked attenuation of NGF-induced gene transcription and neurite outgrowth. Our observations suggest that endophilin B1 regulates TrkA level and downstream functions by controlling the movement of TrkA to late endosomes/lysosomes, possibly acting at the level of early endosomes. © 2009 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/145813
ISSN
2015 SCImago Journal Rankings: 0.846
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:39Z-
dc.date.available2012-03-23T09:49:39Z-
dc.date.issued2009en_HK
dc.identifier.citationCommunicative And Integrative Biology, 2009, v. 2 n. 2, p. 130-132en_HK
dc.identifier.issn1942-0889en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145813-
dc.description.abstractEndophilin B1 is a member of the endophilin family that is localized predominantly to intracellular membranes. Also known as Bax-interacting factor-1 (Bif-1), this protein has been observed to regulate the membrane dynamics of various intracellular compartments, such as the control of mitochondrial morphology and autophagosome formation in fibroblast. Endophilin B1 is expressed in the brain, but its functions in neurons had remained unknown. Recently, we have observed a novel role of endophilin B1 in neurons where it controls the trafficking of TrkA, cognate receptor for the prototypic neurotrophin nerve growth factor (NGF). Knock-down of endophilin B1 expression induces precocious targeting of NGF/TrkA to late endosomes and lysosomes, thereby leading to reduced TrkA levels. This is accompanied by marked attenuation of NGF-induced gene transcription and neurite outgrowth. Our observations suggest that endophilin B1 regulates TrkA level and downstream functions by controlling the movement of TrkA to late endosomes/lysosomes, possibly acting at the level of early endosomes. © 2009 Landes Bioscience.en_HK
dc.languageengen_US
dc.relation.ispartofCommunicative and Integrative Biologyen_HK
dc.titleEndophilin B1. Guarding the gate to destructionen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_US
dc.identifier.authorityCheung, ZH=rp01588en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-67650600993en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650600993&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_HK
dc.identifier.issue2en_HK
dc.identifier.spage130en_HK
dc.identifier.epage132en_HK

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