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Article: The emerging role of autophagy in Parkinson's disease

TitleThe emerging role of autophagy in Parkinson's disease
Authors
KeywordsChemicals And Cas Registry Numbers: Alpha Synuclein, 154040-18-3
Neurotoxin, 39386-17-9
Parkin, 356136-82-8
Issue Date2009
Citation
Molecular Brain, 2009, v. 2 n. 1 How to Cite?
AbstractParkinson's disease (PD) is the most common neurodegenerative movement disorder that affects about 1% of the population worldwide. Despite significant advances in the identification of genetic mutations and signaling pathways that are associated with the disease, the precise mechanisms implicated in the pathophysiology of the disease are not well understood. More importantly, treatments that are effective in reversing the progression of the disease is essentially lacking. Further investigation into the pathogenic mechanisms of PD thus presents a pressing concern for neuroscientists. Recently, deregulation of the autophagic pathway is observed in the brains of PD patients and in models of PD. In this review we summarize current literature on the emerging involvement of autophagy in PD, and the implication for future development of treatment against the disorder. © 2009 Cheung and Ip; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/145812
ISSN
2015 Impact Factor: 3.745
2015 SCImago Journal Rankings: 2.460
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ZHen_HK
dc.contributor.authorIp, NYen_HK
dc.date.accessioned2012-03-23T09:49:39Z-
dc.date.available2012-03-23T09:49:39Z-
dc.date.issued2009en_HK
dc.identifier.citationMolecular Brain, 2009, v. 2 n. 1en_HK
dc.identifier.issn1756-6606en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145812-
dc.description.abstractParkinson's disease (PD) is the most common neurodegenerative movement disorder that affects about 1% of the population worldwide. Despite significant advances in the identification of genetic mutations and signaling pathways that are associated with the disease, the precise mechanisms implicated in the pathophysiology of the disease are not well understood. More importantly, treatments that are effective in reversing the progression of the disease is essentially lacking. Further investigation into the pathogenic mechanisms of PD thus presents a pressing concern for neuroscientists. Recently, deregulation of the autophagic pathway is observed in the brains of PD patients and in models of PD. In this review we summarize current literature on the emerging involvement of autophagy in PD, and the implication for future development of treatment against the disorder. © 2009 Cheung and Ip; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.relation.ispartofMolecular Brainen_HK
dc.subjectChemicals And Cas Registry Numbers: Alpha Synuclein, 154040-18-3en_US
dc.subjectNeurotoxin, 39386-17-9en_US
dc.subjectParkin, 356136-82-8en_US
dc.titleThe emerging role of autophagy in Parkinson's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ZH:zelda@hku.hken_US
dc.identifier.authorityCheung, ZH=rp01588en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1186/1756-6606-2-29en_HK
dc.identifier.pmid19754977-
dc.identifier.pmcidPMC2754442-
dc.identifier.scopuseid_2-s2.0-70350630733en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350630733&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_HK
dc.identifier.issue1en_HK
dc.identifier.isiWOS:000208457100029-
dc.identifier.citeulike9246785-

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