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Article: Poly(vinyl alcohol)/Halloysite nanotubes bionanocomposite films: Properties and in vitro osteoblasts and fibroblasts response

TitlePoly(vinyl alcohol)/Halloysite nanotubes bionanocomposite films: Properties and in vitro osteoblasts and fibroblasts response
Authors
KeywordsBionanocomposite film
Fibroblasts
Halloysite nanotubes
Osteoblasts
Poly(vinyl alcohol)
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/
Citation
Journal Of Biomedical Materials Research - Part A, 2010, v. 93 n. 4, p. 1574-1587 How to Cite?
AbstractIn this study, transparent poly(vinyl alcohol) (PVA) and PVA/halloysite nanotubes (HNTs) bionano-composite films were prepared by solution casting and glutaraldehyde (GA) crosslinking. The surface topography and chemistry of the films were characterized by atomic force microscopy (AFM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, respectively. Blending with HNTs induced changes in nanotopography and surface chemistry of PVA films. The mechanical properties of PVA were enhanced by the incorporated HNTs. The stain-induced crystallization was confirmed by DSC after tensile test. MC3T3-E1 osteoblast-like and NIH 3T3 fibroblast cells were cultured on neat PVA and PVA/HNTs films to evaluate the effects of surface nanotopography and composition on cell behavior. The observations indicated that MC3T3-E1 cell behavior strongly responded to surface nanotopography. On nanotube-dominant surface, cells exhibited a significantly higher level of adhesion than on neat PVA film, whereas neat PVA showed higher degree of osteoblast proliferation compared with PVA/HNTs. In vitro fibroblasts response demonstrated that both neat PVA and PVA/HNTs nanocomposite films were biocompatible and PVA/HNTs films favored to fibroblasts attach and growth below 7.5 wt % of HNTs incorporated. In summary, these results provided insights into understanding of PVA and PVA/HNTs bionanocomposite films in potential applications in bone tissue engineering and drug delivery systems. © 2009 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/145808
ISSN
2015 Impact Factor: 3.263
2015 SCImago Journal Rankings: 0.979
ISI Accession Number ID
Funding AgencyGrant Number
Doctorate Foundation of South China University of Technology
University of Hong Kong10212/10400014/47157/08003/323/01
Funding Information:

Contract grant sponsors: Doctorate Foundation of South China University of Technology, The University of Hong Kong; contract grant number: 10212/10400014/47157/08003/323/01

References

 

DC FieldValueLanguage
dc.contributor.authorZhou, WYen_HK
dc.contributor.authorGuo, Ben_HK
dc.contributor.authorLiu, Men_HK
dc.contributor.authorLiao, Ren_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorJia, Den_HK
dc.date.accessioned2012-03-23T04:03:43Z-
dc.date.available2012-03-23T04:03:43Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part A, 2010, v. 93 n. 4, p. 1574-1587en_HK
dc.identifier.issn1549-3296en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145808-
dc.description.abstractIn this study, transparent poly(vinyl alcohol) (PVA) and PVA/halloysite nanotubes (HNTs) bionano-composite films were prepared by solution casting and glutaraldehyde (GA) crosslinking. The surface topography and chemistry of the films were characterized by atomic force microscopy (AFM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, respectively. Blending with HNTs induced changes in nanotopography and surface chemistry of PVA films. The mechanical properties of PVA were enhanced by the incorporated HNTs. The stain-induced crystallization was confirmed by DSC after tensile test. MC3T3-E1 osteoblast-like and NIH 3T3 fibroblast cells were cultured on neat PVA and PVA/HNTs films to evaluate the effects of surface nanotopography and composition on cell behavior. The observations indicated that MC3T3-E1 cell behavior strongly responded to surface nanotopography. On nanotube-dominant surface, cells exhibited a significantly higher level of adhesion than on neat PVA film, whereas neat PVA showed higher degree of osteoblast proliferation compared with PVA/HNTs. In vitro fibroblasts response demonstrated that both neat PVA and PVA/HNTs nanocomposite films were biocompatible and PVA/HNTs films favored to fibroblasts attach and growth below 7.5 wt % of HNTs incorporated. In summary, these results provided insights into understanding of PVA and PVA/HNTs bionanocomposite films in potential applications in bone tissue engineering and drug delivery systems. © 2009 Wiley Periodicals, Inc.en_HK
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part Aen_HK
dc.rightsJournal OF Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc.-
dc.subjectBionanocomposite filmen_HK
dc.subjectFibroblastsen_HK
dc.subjectHalloysite nanotubesen_HK
dc.subjectOsteoblastsen_HK
dc.subjectPoly(vinyl alcohol)en_HK
dc.subject.meshAluminum Silicates - chemistry-
dc.subject.meshBiocompatible Materials - chemistry-
dc.subject.meshFibroblasts - cytology-
dc.subject.meshNanocomposites - chemistry-
dc.subject.meshPolyvinyl Alcohol - chemistry-
dc.titlePoly(vinyl alcohol)/Halloysite nanotubes bionanocomposite films: Properties and in vitro osteoblasts and fibroblasts responseen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.a.32656en_HK
dc.identifier.pmid20014291-
dc.identifier.scopuseid_2-s2.0-77951572369en_HK
dc.identifier.hkuros173501-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951572369&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1574en_HK
dc.identifier.epage1587en_HK
dc.identifier.isiWOS:000277523600037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, WY=26636766600en_HK
dc.identifier.scopusauthoridGuo, B=7403276339en_HK
dc.identifier.scopusauthoridLiu, M=14519479400en_HK
dc.identifier.scopusauthoridLiao, R=36999347500en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridJia, D=7101755520en_HK

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