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Article: Revisit of the Cardiac Inward Rectifier Potassium Current IK1

TitleRevisit of the Cardiac Inward Rectifier Potassium Current IK1
Authors
KeywordsInward rectifier potassium channels
Cardiac inward rectifier potassium current
IK1
Mg2+
Polyamines
Issue Date2010
PublisherBentham Open. The Journal's web site is located at http://www.bentham.org/open/tocvj/
Citation
The Open Circulation & Vascular Journal, 10, v. 3, p. 95-102 How to Cite?
AbstractInward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that the strong inward rectification of cardiac IK1 channels makes it conduct substantial current near the resting potential but carry little or no current at depolarized potentials. However, recent studies in native cardiac myocytes and HEK 293 cell line stably expressing human Kir2.1 gene have demonstrated that a significant transient outward current carried by IK1 channels is activated by the upstroke of action potential. This review will revisit cardiac IK1 channels, especially the previously-ignored transient outward component of IK1 carried by Kir2.1 channels.
Persistent Identifierhttp://hdl.handle.net/10722/145794
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLi, GR-
dc.contributor.authorDong, MQ-
dc.date.accessioned2012-03-13T04:36:31Z-
dc.date.available2012-03-13T04:36:31Z-
dc.date.issued2010-
dc.identifier.citationThe Open Circulation & Vascular Journal, 10, v. 3, p. 95-102-
dc.identifier.issn1877-3826-
dc.identifier.urihttp://hdl.handle.net/10722/145794-
dc.description.abstractInward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that the strong inward rectification of cardiac IK1 channels makes it conduct substantial current near the resting potential but carry little or no current at depolarized potentials. However, recent studies in native cardiac myocytes and HEK 293 cell line stably expressing human Kir2.1 gene have demonstrated that a significant transient outward current carried by IK1 channels is activated by the upstroke of action potential. This review will revisit cardiac IK1 channels, especially the previously-ignored transient outward component of IK1 carried by Kir2.1 channels.-
dc.languageeng-
dc.publisherBentham Open. The Journal's web site is located at http://www.bentham.org/open/tocvj/-
dc.relation.ispartofThe Open Circulation & Vascular Journal-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectInward rectifier potassium channels-
dc.subjectCardiac inward rectifier potassium current-
dc.subjectIK1-
dc.subjectMg2+-
dc.subjectPolyamines-
dc.titleRevisit of the Cardiac Inward Rectifier Potassium Current IK1en_US
dc.typeArticleen_US
dc.identifier.emailLi, GR: grli@hkucc.hku.hk-
dc.identifier.emailDong, MQ: dongmq@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2174/1877382601003010095-
dc.identifier.hkuros199000-
dc.identifier.volume3-
dc.identifier.spage95-
dc.identifier.epage102-
dc.publisher.placeNetherlands-

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