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Article: Origin of secretin receptor precedes the advent of tetrapoda: Evidence on the separated origins of secretin and orexin

TitleOrigin of secretin receptor precedes the advent of tetrapoda: Evidence on the separated origins of secretin and orexin
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 4 How to Cite?
AbstractAt present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear. In addition, the elusive similarities of secretin and orexin in terms of both structures and functions suggest a common ancestral origin early in the vertebrate lineage. In this article, with the cloning and functional characterization of secretin receptors from lungfish and X. laevis as well as frog (X. laevis and Rana rugulosa) secretins, we provide evidence that the secretin ligand-receptor pair has already diverged and become highly specific by the emergence of tetrapods. The secretin receptor-like sequence cloned from lungfish indicates that the secretin receptor was descended from a VPAC-like receptor prior the advent of sarcopterygians. To clarify the controversial relationship of secretin and orexin, orexin type-2 receptor was cloned from X. laevis. We demonstrated that, in frog, secretin and orexin could activate their mutual receptors, indicating their coordinated complementary role in mediating physiological processes in non-mammalian vertebrates. However, among the peptides in the secretin/glucagon superfamily, secretin was found to be the only peptide that could activate the orexin receptor. We therefore hypothesize that secretin and orexin are of different ancestral origins early in the vertebrate lineage. © 2011 Tam et al.
Persistent Identifierhttp://hdl.handle.net/10722/145793
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Government RGC7639/07M
7696/09M
Committee on Research and Conference10208128
Funding Information:

The present study was supported by the Hong Kong Government RGC grants 7639/07M to Billy K. C. Chow, 7696/09M to Leo T. O. Lee and the Committee on Research and Conference Grants 10208128 to Leo T. O. Lee. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorTam, JKVen_HK
dc.contributor.authorLau, KWen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorFournier, Aen_HK
dc.contributor.authorVaudry, Hen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2012-03-13T03:24:59Z-
dc.date.available2012-03-13T03:24:59Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 4en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145793-
dc.description.abstractAt present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear. In addition, the elusive similarities of secretin and orexin in terms of both structures and functions suggest a common ancestral origin early in the vertebrate lineage. In this article, with the cloning and functional characterization of secretin receptors from lungfish and X. laevis as well as frog (X. laevis and Rana rugulosa) secretins, we provide evidence that the secretin ligand-receptor pair has already diverged and become highly specific by the emergence of tetrapods. The secretin receptor-like sequence cloned from lungfish indicates that the secretin receptor was descended from a VPAC-like receptor prior the advent of sarcopterygians. To clarify the controversial relationship of secretin and orexin, orexin type-2 receptor was cloned from X. laevis. We demonstrated that, in frog, secretin and orexin could activate their mutual receptors, indicating their coordinated complementary role in mediating physiological processes in non-mammalian vertebrates. However, among the peptides in the secretin/glucagon superfamily, secretin was found to be the only peptide that could activate the orexin receptor. We therefore hypothesize that secretin and orexin are of different ancestral origins early in the vertebrate lineage. © 2011 Tam et al.en_HK
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBiological Evolution-
dc.subject.meshIntracellular Signaling Peptides and Proteins - genetics-
dc.subject.meshNeuropeptides - genetics-
dc.subject.meshReceptors, G-Protein-Coupled - genetics-
dc.subject.meshReceptors, Gastrointestinal Hormone - genetics-
dc.titleOrigin of secretin receptor precedes the advent of tetrapoda: Evidence on the separated origins of secretin and orexinen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailNg, KM: skykmng@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityNg, KM=rp01670en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0019384en_HK
dc.identifier.pmid21559418-
dc.identifier.pmcidPMC3084839-
dc.identifier.scopuseid_2-s2.0-79955780832en_HK
dc.identifier.hkuros185539-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955780832&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.isiWOS:000290024700153-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTam, JKV=36830083000en_HK
dc.identifier.scopusauthoridLau, KW=52164114700en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridChu, JYS=34975209300en_HK
dc.identifier.scopusauthoridNg, KM=25122990200en_HK
dc.identifier.scopusauthoridFournier, A=7401993674en_HK
dc.identifier.scopusauthoridVaudry, H=35446602600en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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