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Article: Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer

TitleEllagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer
Authors
KeywordsAnti-angiogenesis
Breast cancer
Ellagic acid
Molecular docking
VEGF/VEGFR2
Issue Date2012
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-6806
Citation
Breast Cancer Research And Treatment, 2012, v. 134 n. 3, p. 943-955 How to Cite?
AbstractAnti-angiogenesis targeting VEGFR-2 has been considered as an important strategy for cancer therapy. Ellagic acid is a naturally existing polyphenol widely found in fruits and vegetables. It was reported that ellagic acid interfered with some angiogenesis-dependent pathologies. Yet the mechanisms involved were not fully understood. Thus, we analyzed its anti-angiogenesis effects and mechanisms on human breast cancer utilizing in-vitro and in-vivo methodologies. The in-silico analysis was also carried out to further analyze the structure-based interaction between ellagic acid and VEGFR-2. We found that ellagic acid significantly inhibited a series of VEGF-induced angiogenesis processes including proliferation, migration, and tube formation of endothelial cells. Besides, it directly inhibited VEGFR-2 tyrosine kinase activity and its downstream signaling pathways including MAPK and PI3K/Akt in endothelial cells. Ellagic acid also obviously inhibited neo-vessel formation in chick chorioallantoic membrane and sprouts formation of chicken aorta. Breast cancer xenografts study also revealed that ellagic acid significantly inhibited MDA-MB-231 cancer growth and P-VEGFR2 expression. Molecular docking simulation indicated that ellagic acid could form hydrogen bonds and aromatic interactions within the ATP-binding region of the VEGFR-2 kinase unit. Taken together, ellagic acid could exert anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. © 2012 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/145629
ISSN
2015 Impact Factor: 4.085
2015 SCImago Journal Rankings: 2.424
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Nen_HK
dc.contributor.authorWang, ZYen_HK
dc.contributor.authorMo, SLen_HK
dc.contributor.authorLoo, TYen_HK
dc.contributor.authorWang, DMen_HK
dc.contributor.authorLuo, HBen_HK
dc.contributor.authorYang, DPen_HK
dc.contributor.authorChen, YLen_HK
dc.contributor.authorShen, JGen_HK
dc.contributor.authorChen, JPen_HK
dc.date.accessioned2012-02-28T01:59:11Z-
dc.date.available2012-02-28T01:59:11Z-
dc.date.issued2012en_HK
dc.identifier.citationBreast Cancer Research And Treatment, 2012, v. 134 n. 3, p. 943-955en_HK
dc.identifier.issn0167-6806en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145629-
dc.description.abstractAnti-angiogenesis targeting VEGFR-2 has been considered as an important strategy for cancer therapy. Ellagic acid is a naturally existing polyphenol widely found in fruits and vegetables. It was reported that ellagic acid interfered with some angiogenesis-dependent pathologies. Yet the mechanisms involved were not fully understood. Thus, we analyzed its anti-angiogenesis effects and mechanisms on human breast cancer utilizing in-vitro and in-vivo methodologies. The in-silico analysis was also carried out to further analyze the structure-based interaction between ellagic acid and VEGFR-2. We found that ellagic acid significantly inhibited a series of VEGF-induced angiogenesis processes including proliferation, migration, and tube formation of endothelial cells. Besides, it directly inhibited VEGFR-2 tyrosine kinase activity and its downstream signaling pathways including MAPK and PI3K/Akt in endothelial cells. Ellagic acid also obviously inhibited neo-vessel formation in chick chorioallantoic membrane and sprouts formation of chicken aorta. Breast cancer xenografts study also revealed that ellagic acid significantly inhibited MDA-MB-231 cancer growth and P-VEGFR2 expression. Molecular docking simulation indicated that ellagic acid could form hydrogen bonds and aromatic interactions within the ATP-binding region of the VEGFR-2 kinase unit. Taken together, ellagic acid could exert anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. © 2012 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-6806en_HK
dc.relation.ispartofBreast Cancer Research and Treatmenten_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnti-angiogenesisen_HK
dc.subjectBreast canceren_HK
dc.subjectEllagic aciden_HK
dc.subjectMolecular dockingen_HK
dc.subjectVEGF/VEGFR2en_HK
dc.titleEllagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast canceren_HK
dc.typeArticleen_HK
dc.identifier.emailShen, JG: shenjg@hku.hken_HK
dc.identifier.emailChen, JP: abchen@hku.hken_HK
dc.identifier.authorityShen, JG=rp00487en_HK
dc.identifier.authorityChen, JP=rp01316en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s10549-012-1977-9en_HK
dc.identifier.pmid22350787-
dc.identifier.scopuseid_2-s2.0-84868195812en_HK
dc.identifier.hkuros198772en_US
dc.identifier.spage1en_HK
dc.identifier.epage13en_HK
dc.identifier.isiWOS:000307273300005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, N=16311384500en_HK
dc.identifier.scopusauthoridWang, ZY=54989199500en_HK
dc.identifier.scopusauthoridMo, SL=24921801300en_HK
dc.identifier.scopusauthoridLoo, TY=7006008583en_HK
dc.identifier.scopusauthoridWang, DM=54985648900en_HK
dc.identifier.scopusauthoridLuo, HB=7401480124en_HK
dc.identifier.scopusauthoridYang, DP=22959396400en_HK
dc.identifier.scopusauthoridChen, YL=54990400400en_HK
dc.identifier.scopusauthoridShen, JG=7404929947en_HK
dc.identifier.scopusauthoridChen, JP=22733695400en_HK
dc.identifier.citeulike10388800-

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