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Article: From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia

TitleFrom rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia
Authors
KeywordsStroke
Preconditioning
Postconditioning
Neuroprotection
Focal ischemia
Cerebral ischemia
Issue Date2012
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdt/index.htm
Citation
Current Drug Targets, 2012, v. 13 n. 2, p. 173-187 How to Cite?
AbstractIschemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. In this article, we first briefly review the history of preconditioning, including the experimentation that initially uncovered its neuroprotective effects and later revealed its underlying mechanisms-of-action. We then discuss how preconditioning research evolved into that of postconditioning -a concept that now represents a broad range of stimuli or triggers, including delayed postconditioning, pharmacological postconditioning, remote postconditioning -and its underlying protective mechanisms involving the Akt, MAPK, PKC and KATP channel cell-signaling pathways. Because the concept of postconditioning is so closely associated with that of preconditioning, and both share some common protective mechanisms, we also discuss whether a combination of preconditioning and postconditioning offers greater protection than preconditioning or postconditioning alone. © 2012 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/145628
ISSN
2015 Impact Factor: 3.029
2015 SCImago Journal Rankings: 1.211
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, Hen_HK
dc.contributor.authorRen, Cen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorShen, Jen_HK
dc.date.accessioned2012-02-28T01:59:10Z-
dc.date.available2012-02-28T01:59:10Z-
dc.date.issued2012en_HK
dc.identifier.citationCurrent Drug Targets, 2012, v. 13 n. 2, p. 173-187en_HK
dc.identifier.issn1389-4501en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145628-
dc.description.abstractIschemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. In this article, we first briefly review the history of preconditioning, including the experimentation that initially uncovered its neuroprotective effects and later revealed its underlying mechanisms-of-action. We then discuss how preconditioning research evolved into that of postconditioning -a concept that now represents a broad range of stimuli or triggers, including delayed postconditioning, pharmacological postconditioning, remote postconditioning -and its underlying protective mechanisms involving the Akt, MAPK, PKC and KATP channel cell-signaling pathways. Because the concept of postconditioning is so closely associated with that of preconditioning, and both share some common protective mechanisms, we also discuss whether a combination of preconditioning and postconditioning offers greater protection than preconditioning or postconditioning alone. © 2012 Bentham Science Publishers.en_HK
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdt/index.htmen_HK
dc.relation.ispartofCurrent Drug Targetsen_HK
dc.subjectStrokeen_HK
dc.subjectPreconditioningen_HK
dc.subjectPostconditioningen_HK
dc.subjectNeuroprotectionen_HK
dc.subjectFocal ischemiaen_HK
dc.subjectCerebral ischemiaen_HK
dc.subject.meshBrain - blood supply-
dc.subject.meshBrain Ischemia - metabolism - therapy-
dc.subject.meshIschemic Postconditioning - methods-
dc.subject.meshIschemic Preconditioning - methods-
dc.subject.meshNeuroprotective Agents - therapeutic use-
dc.titleFrom rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemiaen_HK
dc.typeArticleen_HK
dc.identifier.emailShen, J: shenjg@hku.hken_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.2174/138945012799201621en_HK
dc.identifier.pmid22204317-
dc.identifier.pmcidPMC3346695-
dc.identifier.scopuseid_2-s2.0-84863129642en_HK
dc.identifier.hkuros198758en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863129642&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue2en_HK
dc.identifier.spage173en_HK
dc.identifier.epage187en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridShen, J=7404929947en_HK
dc.identifier.scopusauthoridChen, X=36670920600en_HK
dc.identifier.scopusauthoridRen, C=7102469815en_HK
dc.identifier.scopusauthoridZhao, H=7404779202en_HK
dc.customcontrol.immutablehys 130315-

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