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Article: An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation

TitleAn effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation
Authors
KeywordsNanoparticles
Oxidative stress
Antioxidant
Free radicals
Cell toxicity
Issue Date2013
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/17435390.asp
Citation
Nanotoxicology, 2013, v. 7 n. 3, p. 294-300 How to Cite?
AbstractAbstract To suppress the cytotoxicity of gold nanoparticles (AuNPs), danshensu, a naturally occurring polyphenol antioxidant isolated from Chinese herb, was used to provide a fundamental protection layer for AuNPs, to alleviate oxidative stress and as a reducing agent to react with chloroauric acid. Besides danshensu, gum arabic was chosen as an auxiliary stabilising agent to improve the stability of AuNPs against aggregation. As expected, the prepared GA-DS-AuNPs (gum arabic-danshensu-gold nanoparticle) was remarkably stable in various buffer solutions. More interestingly, the GA-DS-AuNPs not only did not show any appreciable cytotoxicity, but also could alleviate the oxidative damage induced by AuNPs. Meanwhile, the ROS/RNS scavenging activities of GA-DS-AuNPs was evaluated by electron spin resonance spectroscopy (ESR), potentiometric nitric oxide (NO) sensor and cell confocal imaging. The results suggest that GA-DS-AuNPs might have effectively reduced the AuNPs-induced cytotoxicity and oxidative stress by downregulation of ROS/NOS production. The GA-DS-AuNPs may provide potential opportunities for the application in nanomedicine and nanobiology.
Persistent Identifierhttp://hdl.handle.net/10722/145626
ISSN
2015 SCImago Journal Rankings: 2.166
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDu, Len_US
dc.contributor.authorMiao, Xen_US
dc.contributor.authorJiang, Yen_US
dc.contributor.authorJia, Hen_US
dc.contributor.authorTian, Qen_US
dc.contributor.authorShen, Jen_US
dc.contributor.authorLiu, Yen_US
dc.date.accessioned2012-02-28T01:59:09Z-
dc.date.available2012-02-28T01:59:09Z-
dc.date.issued2013en_US
dc.identifier.citationNanotoxicology, 2013, v. 7 n. 3, p. 294-300en_US
dc.identifier.issn1743-5404-
dc.identifier.urihttp://hdl.handle.net/10722/145626-
dc.description.abstractAbstract To suppress the cytotoxicity of gold nanoparticles (AuNPs), danshensu, a naturally occurring polyphenol antioxidant isolated from Chinese herb, was used to provide a fundamental protection layer for AuNPs, to alleviate oxidative stress and as a reducing agent to react with chloroauric acid. Besides danshensu, gum arabic was chosen as an auxiliary stabilising agent to improve the stability of AuNPs against aggregation. As expected, the prepared GA-DS-AuNPs (gum arabic-danshensu-gold nanoparticle) was remarkably stable in various buffer solutions. More interestingly, the GA-DS-AuNPs not only did not show any appreciable cytotoxicity, but also could alleviate the oxidative damage induced by AuNPs. Meanwhile, the ROS/RNS scavenging activities of GA-DS-AuNPs was evaluated by electron spin resonance spectroscopy (ESR), potentiometric nitric oxide (NO) sensor and cell confocal imaging. The results suggest that GA-DS-AuNPs might have effectively reduced the AuNPs-induced cytotoxicity and oxidative stress by downregulation of ROS/NOS production. The GA-DS-AuNPs may provide potential opportunities for the application in nanomedicine and nanobiology.-
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/17435390.asp-
dc.relation.ispartofNanotoxicologyen_US
dc.rightsNanotoxicology. Copyright © Informa Healthcare.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectNanoparticles-
dc.subjectOxidative stress-
dc.subjectAntioxidant-
dc.subjectFree radicals-
dc.subjectCell toxicity-
dc.titleAn effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formationen_US
dc.typeArticleen_US
dc.identifier.emailShen, J: shenjg@hku.hken_US
dc.identifier.authorityShen, J=rp00487en_US
dc.description.naturepostprint-
dc.identifier.doi10.3109/17435390.2011.653415-
dc.identifier.pmid22313229-
dc.identifier.hkuros198755en_US
dc.identifier.volume7en_US
dc.identifier.issue3-
dc.identifier.spage294en_US
dc.identifier.epage300en_US
dc.identifier.eissn1743-5404-
dc.identifier.isiWOS:000317497000005-
dc.publisher.placeUnited Kingdom-

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